(Q47388950)

English

Predicting P-glycoprotein effects on oral absorption: correlation of transport in Caco-2 with drug pharmacokinetics in wild-type and mdr1a(-/-) mice in vivo.

scientific article published in May 2004

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15180340%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

Predicting P-glycoprotein effects on oral absorption: correlation of transport in Caco-2 with drug pharmacokinetics in wild-type and mdr1a(-/-) mice in vivo (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15180340%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

1 reference

based on heuristic

inferred from title

pharmacokinetics

1 reference

based on heuristic

inferred from title

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15180340%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15180340%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

author name string

Jolanta Tanianis-Hughes

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15180340%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

Geoff Warhurst

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15180340%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

publication date

1 May 2004

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15180340%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

Pharmaceutical Research

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15180340%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

21

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15180340%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15180340%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

819-826

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15180340%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

Drug-drug interaction mediated by inhibition and induction of P-glycoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of drug interactions with P-glycoprotein in drug discovery: in vitro assessment of the potential for drug-drug interactions with P-glycoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P-glycoprotein-dependent disposition kinetics of tacrolimus: studies in mdr1a knockout mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Predicting drug absorption: how nature made it a difficult problem.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Region-dependent modulation of intestinal permeability by drug efflux transporters: in vitro studies in mdr1a(-/-) mouse intestine

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of transport proteins in drug absorption, distribution and excretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of P-glycoprotein in pharmacokinetics: clinical implications

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of genes encoding for drug metabolising cytochrome P450 enzymes and P-glycoprotein in the rat small intestine; comparison to the liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rational use of in vitro P-glycoprotein assays in drug discovery

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of P-glycoprotein in determining the oral absorption and clearance of the NK2 antagonist, UK-224,671.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Utility of Mdr1-gene deficient mice in assessing the impact of P-glycoprotein on pharmacokinetics and pharmacodynamics in drug discovery and development

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P-glycoprotein: a major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered expression of hepatic cytochromes P-450 in mice deficient in one or more mdr1 genes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A high-throughput screening microplate test for the interaction of drugs with P-glycoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro and in vivo models for assessing drug efflux transporter activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetic profiling of P-glycoprotein-mediated drug efflux in rat and human intestinal epithelia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative evaluation of the function of small intestinal P-glycoprotein: comparative studies between in situ and in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resolution of P-glycoprotein and non-P-glycoprotein effects on drug permeability using intestinal tissues from mdr1a (-/-) mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of transporters in the tissue-selective distribution and elimination of drugs: transporters in the liver, small intestine, brain and kidney

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The drug efflux-metabolism alliance: biochemical aspects.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of mdr1a P-glycoprotein gene disruption, gender, and substrate concentration on brain uptake of selected compounds

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr 1a P-glycoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1023/B:PHAM.0000026434.82855.69

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15180340%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15180340%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

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