(Q39004351)

8 September 2017

1 reference

title

The activities of amyloids from a structural perspective (English)

1 reference

8 September 2017

Roland Riek

1

1 reference

PubMed ID

27830791

8 September 2017

David S Eisenberg

series ordinal

2

1 reference

PubMed ID

27830791

8 September 2017

language of work or name

English

0 references

publication date

9 November 2016

1 reference

8 September 2017

1 reference

8 September 2017

539

1 reference

8 September 2017

7628

1 reference

8 September 2017

227-235

1 reference

https://scigraph.springernature.com/pub.10.1038/nature20416

8 September 2017

0 references

cites work

Nomenclature 2014: Amyloid fibril proteins and clinical classification of the amyloidosis.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Normal transthyretin and synthetic transthyretin fragments form amyloid-like fibrils in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Partial denaturation of transthyretin is sufficient for amyloid fibril formation in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Functional amyloid--from bacteria to humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Protein misfolding, functional amyloid, and human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

The amyloid state and its association with protein misfolding diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Biology of amyloid: structure, function, and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

The amyloid state of proteins in human diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Targeting protein aggregation for the treatment of degenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

The emerging concept of functional amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Functional amyloids as natural storage of peptide hormones in pituitary secretory granules

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Common core structure of amyloid fibrils by synchrotron X-ray diffraction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

The protofilament structure of insulin amyloid fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Structure of the cross-beta spine of amyloid-like fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Atomic structures of amyloid cross-beta spines reveal varied steric zippers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Molecular basis for insulin fibril assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Atomic structures of IAPP (amylin) fusions suggest a mechanism for fibrillation and the role of insulin in the process

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Molecular mechanisms for protein-encoded inheritance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Molecular basis for amyloid- polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Crystallographic Studies of Prion Protein (PrP) Segments Suggest How Structural Changes Encoded by Polymorphism at Residue 129 Modulate Susceptibility to Human Prion Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Atomic Structures Suggest Determinants of Transmission Barriers in Mammalian Prion Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Crystal Structures of IAPP Amyloidogenic Segments Reveal a Novel Packing Motif of Out-of-Register Beta Sheets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Uncovering the Mechanism of Aggregation of Human Transthyretin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Structure of the toxic core of α-synuclein from invisible crystals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

An amyloid-forming peptide from the yeast prion Sup35 reveals a dehydrated beta-sheet structure for amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Cooperative hydrogen bonding in amyloid formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

The formation, function and regulation of amyloids: insights from structural biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Out-of-register -sheets suggest a pathway to toxic amyloid aggregates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Solid-state NMR study of amyloid nanocrystals and fibrils formed by the peptide GNNQQNY from yeast prion protein Sup35p.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Peptide dimer structure in an Aβ(1-42) fibril visualized with cryo-EM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Atomic Resolution Structure of Monomorphic Aβ42 Amyloid Fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Atomic-resolution structure of a disease-relevant Aβ(1-42) amyloid fibril

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Aβ(1-42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Ex vivo mammalian prions are formed of paired double helical prion protein fibrils.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

The Structural Architecture of an Infectious Mammalian Prion Using Electron Cryomicroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Parallel in-register intermolecular β-sheet architectures for prion-seeded prion protein (PrP) amyloids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Molecular conformation and dynamics of the Y145Stop variant of human prion protein in amyloid fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Progress towards structural understanding of infectious sheep PrP-amyloid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Structural polymorphism in amyloids: new insights from studies with Y145Stop prion protein fibrils.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

The protein product of the het-s heterokaryon incompatibility gene of the fungus Podospora anserina behaves as a prion analog

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Amyloid fibrils of the HET-s(218-289) prion form a beta solenoid with a triangular hydrophobic core

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Rational design of potent human transthyretin amyloid disease inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

The fold of alpha-synuclein fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Structural and functional characterization of two alpha-synuclein strains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Abeta(1-40) fibril polymorphism implies diverse interaction patterns in amyloid fibrils.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Solid-state NMR sequential assignment of an Amyloid-β(1-42) fibril polymorph.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Physical and structural basis for polymorphism in amyloid fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Molecular structural basis for polymorphism in Alzheimer's -amyloid fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Principles that govern the folding of protein chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Contribution of specific residues of the β-solenoid fold to HET-s prion function, amyloid structure and stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Multidimensional structure-activity relationship of a protein in its aggregated states

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Prion-like aggregation of mutant p53 in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Mutant p53 aggregates into prion-like amyloid oligomers and fibrils: implications for cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

The HET-S/s Prion Motif in the Control of Programmed Cell Death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

The mechanism of toxicity in HET-S/HET-s prion incompatibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

A super-assembly of Whi3 encodes memory of deceptive encounters by single cells during yeast courtship.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Aplysia CPEB can form prion-like multimers in sensory neurons that contribute to long-term facilitation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

A neuronal isoform of the aplysia CPEB has prion-like properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Selective incorporation of polyanionic molecules into hamster prions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Elucidating the role of cofactors in mammalian prion propagation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Conformational variations in an infectious protein determine prion strain differences

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

On the lag phase in amyloid fibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Role of the chaperone protein Hsp104 in propagation of the yeast prion-like factor [psi+]

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Does the agent of scrapie replicate without nucleic acid?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Self-replication and scrapie

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Novel proteinaceous infectious particles cause scrapie

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

[PSI+], SUP35, and chaperones

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Yeast prions act as genes composed of self-propagating protein amyloids

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

The [URE3] prion is an aggregated form of Ure2p that can be cured by overexpression of Ure2p fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Support for the prion hypothesis for inheritance of a phenotypic trait in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

In vitro generation of infectious scrapie prions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Generating a prion with bacterially expressed recombinant prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Correlation of structural elements and infectivity of the HET-s prion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Titration of biologically active amyloid-β seeds in a transgenic mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Neuronal activity enhances tau propagation and tau pathology in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Transmissibility of systemic amyloidosis by a prion-like mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain Tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Cell Biology of Prions and Prionoids: A Status Report

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

The transcellular spread of cytosolic amyloids, prions, and prionoids

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Birth of a prion: spontaneous generation revisited

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

BSE prions propagate as either variant CJD-like or sporadic CJD-like prion strains in transgenic mice expressing human prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Co-existence of scrapie prion protein types 1 and 2 in sporadic Creutzfeldt-Jakob disease: its effect on the phenotype and prion-type characteristics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Prion strain discrimination using luminescent conjugated polymers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Classification of sporadic Creutzfeldt-Jakob disease revisited.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Protein-only transmission of three yeast prion strains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

The structural basis of yeast prion strain variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Darwinian evolution of prions in cell culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Acquisition of drug resistance and dependence by prions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

A general model of prion strains and their pathogenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Selforganization of matter and the evolution of biological macromolecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Alpha-synuclein in Lewy bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Dominant pro-vasopressin mutants that cause diabetes insipidus form disulfide-linked fibrillar aggregates in the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Anchorless prion protein results in infectious amyloid disease without clinical scrapie

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Prion propagation and toxicity in vivo occur in two distinct mechanistic phases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

A beta oligomers - a decade of discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Alzheimer's disease: the amyloid cascade hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

The most infectious prion protein particles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Fibrillar α-synuclein and huntingtin exon 1 assemblies are toxic to the cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Neurodegenerative disease: amyloid pores from pathogenic mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Atomic View of a Toxic Amyloid Small Oligomer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Abeta42 neurotoxicity is mediated by ongoing nucleated polymerization process rather than by discrete Abeta42 species

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Mechanism of membrane interaction and disruption by α-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Current and future treatment of amyloid diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

The BRICHOS domain, amyloid fibril formation, and their relationship

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

The transthyretin amyloidoses: from delineating the molecular mechanism of aggregation linked to pathology to a regulatory-agency-approved drug

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Implications for Alzheimer's disease of an atomic resolution structure of amyloid-β(1-42) fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

The X-ray interpretation of denaturation and the structure of the seed globulins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Kinetics of nucleation-controlled polymerization. A perturbation treatment for use with a secondary pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

In vitro formation of amyloid from alpha-synuclein is dominated by reactions at hydrophobic interfaces.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

An analytical solution to the kinetics of breakable filament assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Transthyretin aggregation under partially denaturing conditions is a downhill polymerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Gain of function of mutant p53 by coaggregation with multiple tumor suppressors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

The structure of amyloid fibrils by electron microscopy and X-ray diffraction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

Cell biology: Infectious Alzheimer's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20416

The presence of an air-water interface affects formation and elongation of α-Synuclein fibrils

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27830791

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Polymerization of flagellin and polymorphism of flagella.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27830791

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Very long term studies of the seeding of beta-amyloidosis in primates

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27830791

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NATURE20416

1 reference

8 September 2017

1 reference

PubMed ID

27830791