(Q37975816)

English

The transthyretin amyloidoses: from delineating the molecular mechanism of aggregation linked to pathology to a regulatory-agency-approved drug

scientific article published on 05 January 2012

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scholarly article

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Europe PubMed Central

PMC publication ID

26 August 2017

The transthyretin amyloidoses: from delineating the molecular mechanism of aggregation linked to pathology to a regulatory-agency-approved drug (English)

1 reference

Europe PubMed Central

PMC publication ID

26 August 2017

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4

1 reference

Europe PubMed Central

PMC publication ID

26 August 2017

Jeffery W. Kelly

5

object named as

Jeffery W Kelly

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Europe PubMed Central

PMC publication ID

26 August 2017

author name string

Steven M Johnson

1

1 reference

Europe PubMed Central

PMC publication ID

26 August 2017

Stephen Connelly

2

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Europe PubMed Central

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26 August 2017

Colleen Fearns

3

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Europe PubMed Central

PMC publication ID

26 August 2017

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publication date

5 January 2012

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Europe PubMed Central

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26 August 2017

number of pages

19

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Journal of Molecular Biology

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Europe PubMed Central

PMC publication ID

26 August 2017

421

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Europe PubMed Central

PMC publication ID

26 August 2017

2-3

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Europe PubMed Central

PMC publication ID

26 August 2017

185-203

1 reference

Europe PubMed Central

PMC publication ID

26 August 2017

Tafamidis for transthyretin familial amyloid polyneuropathy: a randomized, controlled trial

1 reference

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Neuronal production of transthyretin in human and murine Alzheimer's disease: is it protective?

1 reference

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Ligand binding to distinct states diverts aggregation of an amyloid-forming protein

1 reference

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Potent Kinetic Stabilizers That Prevent Transthyretin-Mediated Cardiomyocyte Proteotoxicity

1 reference

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Mechanisms of transthyretin cardiomyocyte toxicity inhibition by resveratrol analogs

1 reference

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Targets for AD treatment: conflicting messages from γ-secretase inhibitors

1 reference

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A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin

1 reference

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Immunoglobulin light chain amyloidosis: 2011 update on diagnosis, risk-stratification, and management

1 reference

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Sulfated glycosaminoglycans accelerate transthyretin amyloidogenesis by quaternary structural conversion

1 reference

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Trapping of palindromic ligands within native transthyretin prevents amyloid formation

1 reference

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6 September 2017

A stilbene that binds selectively to transthyretin in cells and remains dark until it undergoes a chemoselective reaction to create a bright blue fluorescent conjugate

1 reference

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Structure, mechanism and inhibition of gamma-secretase and presenilin-like proteases

1 reference

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1 reference

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Conformational differences between the wild type and V30M mutant transthyretin modulate its binding to genistein: implications to tetramer stability and ligand-binding

1 reference

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Can Alzheimer disease be prevented by amyloid-beta immunotherapy?

1 reference

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Identifying the amylome, proteins capable of forming amyloid-like fibrils

1 reference

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6 September 2017

Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidoses

1 reference

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6 September 2017

Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma

1 reference

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A Substructure Combination Strategy To Create Potent and Selective Transthyretin Kinetic Stabilizers That Prevent Amyloidogenesis and Cytotoxicity

1 reference

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6 September 2017

Reduced IGF-1 signaling delays age-associated proteotoxicity in mice

1 reference

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Amyloid imaging in aging and dementia: testing the amyloid hypothesis in vivo

1 reference

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Biological and chemical approaches to diseases of proteostasis deficiency

1 reference

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6 September 2017

Toward Optimization of the Second Aryl Substructure Common to Transthyretin Amyloidogenesis Inhibitors Using Biochemical and Structural Studies †

1 reference

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6 September 2017

Pathogenesis of and therapeutic strategies to ameliorate the transthyretin amyloidoses

1 reference

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6 September 2017

Toward Optimization of the Linker Substructure Common to Transthyretin Amyloidogenesis Inhibitors Using Biochemical and Structural Studies †

1 reference

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6 September 2017

Structural insight into pH-induced conformational changes within the native human transthyretin tetramer

1 reference

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6 September 2017

Amyloid disease prevention by transthyretin native state complexation with carborane derivatives lacking cyclooxygenase inhibition

1 reference

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6 September 2017

Quantification of the thermodynamically linked quaternary and tertiary structural stabilities of transthyretin and its disease-associated variants: the relationship between stability and amyloidosis.

1 reference

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6 September 2017

Adapting proteostasis for disease intervention

1 reference

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6 September 2017

Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of Abeta toxicity

1 reference

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6 September 2017

Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors

1 reference

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6 September 2017

Treatment of light chain (AL) amyloidosis with the combination of bortezomib and dexamethasone

1 reference

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6 September 2017

Design of mechanism-based inhibitors of transthyretin amyloidosis: studies with biphenyl ethers and new structural templates

1 reference

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6 September 2017

Transthyretin and familial amyloidotic polyneuropathy. Recent progress in understanding the molecular mechanism of neurodegeneration

1 reference

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6 September 2017

Orally administered diflunisal stabilizes transthyretin against dissociation required for amyloidogenesis

1 reference

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6 September 2017

Current and emerging views and treatments of systemic immunoglobulin light-chain (Al) amyloidosis

1 reference

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6 September 2017

Opposing activities protect against age-onset proteotoxicity

1 reference

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6 September 2017

Native state kinetic stabilization as a strategy to ameliorate protein misfolding diseases: a focus on the transthyretin amyloidoses.

1 reference

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6 September 2017

The pathway by which the tetrameric protein transthyretin dissociates.

1 reference

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6 September 2017

Small transthyretin (TTR) ligands as possible therapeutic agents in TTR amyloidoses

1 reference

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6 September 2017

Genistein, a natural product from soy, is a potent inhibitor of transthyretin amyloidosis

1 reference

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6 September 2017

Diagnosis and management of the cardiac amyloidoses

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6 September 2017

Senile systemic amyloidosis presenting with heart failure: a comparison with light chain-associated amyloidosis.

1 reference

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6 September 2017

The biological and chemical basis for tissue-selective amyloid disease

1 reference

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6 September 2017

Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation

1 reference

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6 September 2017

Intrinsically unstructured proteins and their functions

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6 September 2017

Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

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Hydroxylated polychlorinated biphenyls selectively bind transthyretin in blood and inhibit amyloidogenesis: rationalizing rodent PCB toxicity

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6 September 2017

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6 September 2017

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6 September 2017

Plasma retinol-binding protein: structure and interactions with retinol, retinoids, and transthyretin

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6 September 2017

Tissue damage in the amyloidoses: Transthyretin monomers and nonnative oligomers are the major cytotoxic species in tissue culture

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6 September 2017

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6 September 2017

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6 September 2017

Folding proteins in fatal ways

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6 September 2017

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6 September 2017

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6 September 2017

Synthesis and characterization of potent bivalent amyloidosis inhibitors that bind prior to transthyretin tetramerization

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6 September 2017

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6 September 2017

A peculiar form of peripheral neuropathy; familiar atypical generalized amyloidosis with special involvement of the peripheral nerves

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6 September 2017

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6 September 2017

Benzoxazoles as transthyretin amyloid fibril inhibitors: synthesis, evaluation, and mechanism of action

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6 September 2017

D18G transthyretin is monomeric, aggregation prone, and not detectable in plasma and cerebrospinal fluid: a prescription for central nervous system amyloidosis?

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6 September 2017

Prevention of transthyretin amyloid disease by changing protein misfolding energetics.

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6 September 2017

Evidence for early cytotoxic aggregates in transgenic mice for human transthyretin Leu55Pro

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6 September 2017

Amyloid-beta immunotherapy for Alzheimer's disease: the end of the beginning

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6 September 2017

Sequence-dependent denaturation energetics: A major determinant in amyloid disease diversity

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6 September 2017

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6 September 2017

The V122I cardiomyopathy variant of transthyretin increases the velocity of rate-limiting tetramer dissociation, resulting in accelerated amyloidosis

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6 September 2017

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6 September 2017

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6 September 2017

Support for the multigenic hypothesis of amyloidosis: the binding stoichiometry of retinol-binding protein, vitamin A, and thyroid hormone influences transthyretin amyloidogenicity in vitro

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

Evaluating the binding selectivity of transthyretin amyloid fibril inhibitors in blood plasma

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6 September 2017

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6 September 2017

Rational design of potent human transthyretin amyloid disease inhibitors

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6 September 2017

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6 September 2017

Autonomic dysfunction in familial amyloidotic polyneuropathy (FAP)

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6 September 2017

Tertiary structures of amyloidogenic and non-amyloidogenic transthyretin variants: new model for amyloid fibril formation

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6 September 2017

Inhibiting transthyretin conformational changes that lead to amyloid fibril formation

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6 September 2017

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

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6 September 2017

Amyloid fibril formation by an SH3 domain

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6 September 2017

Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis

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6 September 2017

Variant-sequence transthyretin (isoleucine 122) in late-onset cardiac amyloidosis in black Americans

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6 September 2017

Inhibiting transthyretin amyloid fibril formation via protein stabilization

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6 September 2017

Familial amyloid polyneuropathy: new developments in genetics and treatment

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6 September 2017

Alternative conformations of amyloidogenic proteins govern their behavior

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6 September 2017

The acid-mediated denaturation pathway of transthyretin yields a conformational intermediate that can self-assemble into amyloid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

6 September 2017

Transthyretin mutation Leu-55-Pro significantly alters tetramer stability and increases amyloidogenicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

6 September 2017

A role for destabilizing amino acid replacements in light-chain amyloidosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

6 September 2017

Clinical improvement and amyloid regression after liver transplantation in hereditary transthyretin amyloidosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

6 September 2017

Structure of a complex of two plasma proteins: transthyretin and retinol-binding protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

6 September 2017

Transthyretin mutations in health and disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

6 September 2017

Amyloid fibril protein in familial amyloidotic polyneuropathy, Portuguese type. Definition of molecular abnormality in transthyretin (prealbumin).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

6 September 2017

Transport of thyroid hormones in serum and cerebrospinal fluid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

6 September 2017

Transthyretin: a choroid plexus-specific transport protein in human brain. The 1986 S. Weir Mitchell award

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

6 September 2017

Familial amyloidotic polyneuropathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

6 September 2017

Fibril in senile systemic amyloidosis is derived from normal transthyretin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

6 September 2017

Mechanism of molecular recognition. Structural aspects of 3,3'-diiodo-L-thyronine binding to human serum transthyretin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

6 September 2017

Variations in thyroid hormone transport proteins and their clinical implications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

6 September 2017

Partial denaturation of transthyretin is sufficient for amyloid fibril formation in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

6 September 2017

The interaction between retinol-binding proteins and prealbumins studied by fluorescence polarization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

6 September 2017

Structure of prealbumin: secondary, tertiary and quaternary interactions determined by Fourier refinement at 1.8 A

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

6 September 2017

Cell based screening of inhibitors of transthyretin aggregation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

14 September 2017

Deuterium-proton exchange on the native wild-type transthyretin tetramer identifies the stable core of the individual subunits and indicates mobility at the subunit interface

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

28 September 2017

A glimpse of a possible amyloidogenic intermediate of transthyretin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

28 September 2017

Thyroid hormone transport proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

28 September 2017

Amyloid-β forms fibrils by nucleated conformational conversion of oligomers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

23 June 2018

Progression of transthyretin amyloid neuropathy after liver transplantation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

23 June 2018

The kinetics of nucleated polymerizations at high concentrations: amyloid fibril formation near and above the "supercritical concentration".

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

23 June 2018

Partitioning conformational intermediates between competing refolding and aggregation pathways: insights into transthyretin amyloid disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

23 June 2018

The most pathogenic transthyretin variant, L55P, forms amyloid fibrils under acidic conditions and protofilaments under physiological conditions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

23 June 2018

Serum amyloid P component scintigraphy in familial amyloid polyneuropathy: regression of visceral amyloid following liver transplantation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

23 June 2018

The alternative conformations of amyloidogenic proteins and their multi-step assembly pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

23 June 2018

Transthyretin quaternary and tertiary structural changes facilitate misassembly into amyloid.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

23 June 2018

Comparison of Lethal and Nonlethal Transthyretin Variants and Their Relationship to Amyloid Disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

23 June 2018

Transthyretin Pro55, a variant associated with early-onset, aggressive, diffuse amyloidosis with cardiac and neurologic involvement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

23 June 2018

Negative cooperativity in the binding of thyroxine to human serum prealbumin. Preparation of tritium-labeled 8-anilino-1-naphthalenesulfonic acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

23 June 2018

Aβ Oligomers Cause Localized Ca2+Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

1 September 2018

Suppression of choroid plexus transthyretin levels by antisense oligonucleotide treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

1 September 2018

Bortezomib with or without dexamethasone in primary systemic (light chain) amyloidosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

1 September 2018

Binding and stabilization of transthyretin by curcumin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

1 September 2018

Engineering a camelid antibody fragment that binds to the active site of human lysozyme and inhibits its conversion into amyloid fibrils

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

1 September 2018

Prediction of aggregation-prone regions in structured proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

1 September 2018

Bortezomib in the treatment of AL amyloidosis: targeted therapy?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

1 September 2018

Targeted suppression of an amyloidogenic transthyretin with antisense oligonucleotides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

1 September 2018

Kinetic stabilization of an oligomeric protein under physiological conditions demonstrated by a lack of subunit exchange: implications for transthyretin amyloidosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

1 September 2018

Potent and selective structure-based dibenzofuran inhibitors of transthyretin amyloidogenesis: kinetic stabilization of the native state

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

1 September 2018

Kinetic stabilization of an oligomeric protein by a single ligand binding event

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

1 September 2018

Kinetic stabilization of the native state by protein engineering: implications for inhibition of transthyretin amyloidogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

1 September 2018

Design, synthesis, and evaluation of oxazole transthyretin amyloidogenesis inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

1 September 2018

Cardiac transplantation for amyloid heart disease: the United Kingdom experience

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

1 September 2018

Structures of human transthyretin complexed with thyroxine at 2.0 A resolution and 3',5'-dinitro-N-acetyl-L-thyronine at 2.2 A resolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

1 September 2018

Transthyretin aggregation under partially denaturing conditions is a downhill polymerization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

1 September 2018

Native state stabilization by NSAIDs inhibits transthyretin amyloidogenesis from the most common familial disease variants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

1 September 2018

Energetic characteristics of the new transthyretin variant A25T may explain its atypical central nervous system pathology.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

1 September 2018

Neurodegenerative disease: amyloid pores from pathogenic mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

1 September 2018

Screening transthyretin amyloid fibril inhibitors: characterization of novel multiprotein, multiligand complexes by mass spectrometry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

1 September 2018

Inhibition of transthyretin amyloid fibril formation by 2,4-dinitrophenol through tetramer stabilization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

1 September 2018

Progression of cardiomyopathy after liver transplantation in patients with familial amyloidotic polyneuropathy, Portuguese type.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

1 September 2018

Anion shielding of electrostatic repulsions in transthyretin modulates stability and amyloidosis: insight into the chaotrope unfolding dichotomy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

1 September 2018

Partially unfolded states of beta(2)-microglobulin and amyloid formation in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

1 September 2018

Analysis of protein aggregation kinetics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

1 September 2018

Genetic anticipation in Portuguese kindreds with familial amyloidotic polyneuropathy is unlikely to be caused by triplet repeat expansions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

1 September 2018

Characterization of the transthyretin acid denaturation pathways by analytical ultracentrifugation: implications for wild-type, V30M, and L55P amyloid fibril formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

1 September 2018

Aging as a major risk for degenerative diseases of the central nervous system.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

1 September 2018

Diflunisal stabilizes familial amyloid polyneuropathy-associated transthyretin variant tetramers in serum against dissociation required for amyloidogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

3 December 2018

Prediction of the Absolute Aggregation Rates of Amyloidogenic Polypeptide Chains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350832

3 December 2018

Biochemical effect of liver transplantation in two Swedish patients with familial amyloidotic polyneuropathy (FAP-met30)

1 reference

https://pubmed.ncbi.nlm.nih.gov/22244854

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hopes remain for an Alzheimer's vaccine

1 reference

https://pubmed.ncbi.nlm.nih.gov/22244854

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transthyretin-derived senile systemic amyloidosis: clinicopathologic and structural considerations

1 reference

https://pubmed.ncbi.nlm.nih.gov/22244854

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modeling polyglutamine pathogenesis in C. elegans

1 reference

https://pubmed.ncbi.nlm.nih.gov/22244854

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of a Japanese Patient with Familial Amyloidotic Polyneuropathy with Orthotopic Liver Transplantation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22244854

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovering transthyretin amyloid fibril inhibitors by limited screening

1 reference

https://pubmed.ncbi.nlm.nih.gov/22244854

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Liver Transplantation Does Not Prevent the Development of Life-Threatening Arrhythmia in Familial Amyloidotic Polyneuropathy, Portuguese-Type (ATTR Val30Met) Patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/22244854

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ten years of international experience with liver transplantation for familial amyloidotic polyneuropathy: results from the Familial Amyloidotic Polyneuropathy World Transplant Registry

1 reference

https://pubmed.ncbi.nlm.nih.gov/22244854

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that the amyloid fibril protein in senile systemic amyloidosis is derived from normal prealbumin

1 reference

https://pubmed.ncbi.nlm.nih.gov/22244854

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and evaluation of anthranilic acid-based transthyretin amyloid fibril inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/22244854

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Native state hydrogen exchange study of suppressor and pathogenic variants of transthyretin

1 reference

https://pubmed.ncbi.nlm.nih.gov/22244854

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-synuclein gene triplication discovered in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22244854

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

-Synuclein gene duplications in sporadic Parkinson disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22244854

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presence of an abnormal transthyretin (prealbumin) in Portuguese patients with familial amyloidotic polyneuropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22244854

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Tetrameric Protein Transthyretin Dissociates to a Non-native Monomer in Solution

1 reference

https://pubmed.ncbi.nlm.nih.gov/22244854

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Guanidine Hydrochloride-Induced Denaturation and Refolding of Transthyretin Exhibits a Marked Hysteresis: Equilibria with High Kinetic Barriers

1 reference

https://pubmed.ncbi.nlm.nih.gov/22244854

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FAP mutations destabilize transthyretin facilitating conformational changes required for amyloid formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22244854

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stress, aging, and neurodegenerative disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22244854

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequence Communication: Tabulation of transthyretin (TTR) variants as of 1/1/2000

1 reference

https://pubmed.ncbi.nlm.nih.gov/22244854

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combined heart and liver transplantation for familial amyloidosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22244854

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.JMB.2011.12.060

1 reference

Europe PubMed Central

PMC publication ID

26 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

26 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

26 August 2017

Sitelinks

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