(Q33541145)

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Improving binding specificity of pharmacological chaperones that target mutant superoxide dismutase-1 linked to familial amyotrophic lateral sclerosis using computational methods

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Europe PubMed Central

PubMed publication ID

27 July 2017

Improving binding specificity of pharmacological chaperones that target mutant superoxide dismutase-1 linked to familial amyotrophic lateral sclerosis using computational methods (English)

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

amyotrophic lateral sclerosis

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molecular chaperones

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1 reference

based on heuristic

inferred from title

author name string

Richard J Nowak

1

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Europe PubMed Central

PubMed publication ID

27 July 2017

Gregory D Cuny

2

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

Sungwoon Choi

3

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

Peter T Lansbury

4

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

Soumya S Ray

5

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Europe PubMed Central

PubMed publication ID

27 July 2017

language of work or name

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publication date

1 April 2010

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Europe PubMed Central

PubMed publication ID

27 July 2017

Journal of Medicinal Chemistry

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Europe PubMed Central

PubMed publication ID

27 July 2017

53

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Europe PubMed Central

PubMed publication ID

27 July 2017

7

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

2709-2718

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

Thermodynamic and structural analysis of highly stabilized BPTIs by single and double mutations

1 reference

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21 June 2018

Modifications of superoxide dismutase (SOD1) in human erythrocytes: a possible role in amyotrophic lateral sclerosis

1 reference

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21 June 2018

Toward Optimization of the Second Aryl Substructure Common to Transthyretin Amyloidogenesis Inhibitors Using Biochemical and Structural Studies †

1 reference

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21 June 2018

Initiation and elongation in fibrillation of ALS-linked superoxide dismutase

1 reference

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21 June 2018

Toward Optimization of the Linker Substructure Common to Transthyretin Amyloidogenesis Inhibitors Using Biochemical and Structural Studies †

1 reference

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21 June 2018

Structures of the G85R variant of SOD1 in familial amyotrophic lateral sclerosis

1 reference

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21 June 2018

SOD1 and amyotrophic lateral sclerosis: mutations and oligomerization

1 reference

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21 June 2018

Metalation of the amyotrophic lateral sclerosis mutant glycine 37 to arginine superoxide dismutase (SOD1) apoprotein restores its structural and dynamical properties in solution to those of metalated wild-type SOD1.

1 reference

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21 June 2018

How do ALS-associated mutations in superoxide dismutase 1 promote aggregation of the protein?

1 reference

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21 June 2018

Orally administered diflunisal stabilizes transthyretin against dissociation required for amyloidogenesis

1 reference

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21 June 2018

Small molecule pharmacological chaperones: From thermodynamic stabilization to pharmaceutical drugs.

1 reference

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21 June 2018

Mutant SOD1 instability: implications for toxicity in amyotrophic lateral sclerosis

1 reference

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21 June 2018

Cell based screening of inhibitors of transthyretin aggregation

1 reference

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21 June 2018

Local unfolding in a destabilized, pathogenic variant of superoxide dismutase 1 observed with H/D exchange and mass spectrometry

1 reference

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Therapeutic strategies to ameliorate lysosomal storage disorders--a focus on Gaucher disease

1 reference

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21 June 2018

Protein aggregation and its consequences for human disease

1 reference

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21 June 2018

Common dynamical signatures of familial amyotrophic lateral sclerosis-associated structurally diverse Cu, Zn superoxide dismutase mutants

1 reference

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21 June 2018

Destabilization of apoprotein is insufficient to explain Cu,Zn-superoxide dismutase-linked ALS pathogenesis.

1 reference

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21 June 2018

Aberrantly increased hydrophobicity shared by mutants of Cu,Zn-superoxide dismutase in familial amyotrophic lateral sclerosis.

1 reference

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21 June 2018

Structural consequences of the familial amyotrophic lateral sclerosis SOD1 mutant His46Arg.

1 reference

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21 June 2018

Small-molecule-mediated stabilization of familial amyotrophic lateral sclerosis-linked superoxide dismutase mutants against unfolding and aggregation

1 reference

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21 June 2018

A possible therapeutic target for Lou Gehrig's disease

1 reference

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21 June 2018

Dimer destabilization in superoxide dismutase may result in disease-causing properties: structures of motor neuron disease mutants.

1 reference

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21 June 2018

Principles of protein folding, misfolding and aggregation

1 reference

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21 June 2018

Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis

1 reference

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21 June 2018

Therapeutic approaches to protein-misfolding diseases

1 reference

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21 June 2018

Amyloid-like filaments and water-filled nanotubes formed by SOD1 mutant proteins linked to familial ALS

1 reference

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21 June 2018

The structure of holo and metal-deficient wild-type human Cu, Zn superoxide dismutase and its relevance to familial amyotrophic lateral sclerosis

1 reference

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21 June 2018

Misfolded CuZnSOD and amyotrophic lateral sclerosis

1 reference

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An alternative mechanism of bicarbonate-mediated peroxidation by copper-zinc superoxide dismutase: rates enhanced via proposed enzyme-associated peroxycarbonate intermediate

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Chemical chaperones increase the cellular activity of N370S beta -glucosidase: a therapeutic strategy for Gaucher disease

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Do oxidatively modified proteins cause ALS?

1 reference

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ALSODatabase: database of SOD1 (and other) gene mutations in ALS on the Internet. European FALS Group and ALSOD Consortium

1 reference

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Decreased metallation and activity in subsets of mutant superoxide dismutases associated with familial amyotrophic lateral sclerosis.

1 reference

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Evaluating the binding selectivity of transthyretin amyloid fibril inhibitors in blood plasma

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Rational design of potent human transthyretin amyloid disease inhibitors

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Loss of in vitro metal ion binding specificity in mutant copper-zinc superoxide dismutases associated with familial amyotrophic lateral sclerosis

1 reference

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Protein aggregation: folding aggregates, inclusion bodies and amyloid

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The metal binding properties of the zinc site of yeast copper-zinc superoxide dismutase: implications for amyotrophic lateral sclerosis

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Identifiers

10.1021/JM901062P

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

ResearchGate publication ID

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