(Q39018278)

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A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies

scientific article published on 6 March 2014

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Europe PubMed Central

PubMed publication ID

8 September 2017

A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies (English)

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

Bob van de Water

6

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Bob van de Water

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Sreenivasa C Ramaiahgari

1

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

Michiel W den Braver

2

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

Bram Herpers

3

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Europe PubMed Central

PubMed publication ID

8 September 2017

Valeska Terpstra

4

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

Jan N M Commandeur

5

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Europe PubMed Central

PubMed publication ID

8 September 2017

Bob van de Water

6

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

Leo S Price

7

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Europe PubMed Central

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8 September 2017

publication date

6 March 2014

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Europe PubMed Central

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8 September 2017

Archives of Toxicology

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Europe PubMed Central

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8 September 2017

88

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Europe PubMed Central

PubMed publication ID

8 September 2017

5

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Europe PubMed Central

PubMed publication ID

8 September 2017

1083-1095

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

Use of sandwich-cultured human hepatocytes to predict biliary clearance of angiotensin II receptor blockers and HMG-CoA reductase inhibitors.

1 reference

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Microtissue size and hypoxia in HTS with 3D cultures

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Characterization of testosterone 11 beta-hydroxylation catalyzed by human liver microsomal cytochromes P450.

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Determination of drug toxicity using 3D spheroids constructed from an immortal human hepatocyte cell line.

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Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

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3D organotypic cultures of human HepaRG cells: a tool for in vitro toxicity studies

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Multicellular tumor spheroids: an underestimated tool is catching up again.

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P-glycoprotein expression, localization, and function in sandwich-cultured primary rat and human hepatocytes: relevance to the hepatobiliary disposition of a model opioid peptide.

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Structure and function of the MRP2 (ABCC2) protein and its role in drug disposition

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A consecutive three alanine residue insertion mutant of human CAR: a novel CAR ligand screening system in HepG2 cells

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Method for generation of homogeneous multicellular tumor spheroids applicable to a wide variety of cell types

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Use of micropatterned cocultures to detect compounds that cause drug-induced liver injury in humans

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Transport mechanism and substrate specificity of human organic anion transporter 2 (hOat2 [SLC22A7]).

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New in vitro tools to study human constitutive androstane receptor (CAR) biology: discovery and comparison of human CAR inverse agonists

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Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation.

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Organotypic liver culture models: meeting current challenges in toxicity testing

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Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes

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Enhanced bile canaliculi formation enabling direct recovery of biliary metabolites of hepatocytes in 3D collagen gel microcavities

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3D organotypic HepaRG cultures as in vitro model for acute and repeated dose toxicity studies.

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Pregnane X receptor protects HepG2 cells from BaP-induced DNA damage

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Improved hepatocyte excretory function by immediate presentation of polarity cues

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Valproic acid metabolism and its effects on mitochondrial fatty acid oxidation: a review

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Organic anion transporter (Slc22a) family members as mediators of toxicity

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Bioactivation of a toxic metabolite of valproic acid, (E)-2-propyl-2,4-pentadienoic acid, via glucuronidation. LC/MS/MS characterization of the GSH-glucuronide diconjugates

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21 January 2018

Human liver cell spheroids in extended perfusion bioreactor culture for repeated-dose drug testing

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Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver

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The maintenance and generation of membrane polarity in hepatocytes

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Predicting in vivo drug interactions from in vitro drug discovery data

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Cellular imaging predictions of clinical drug-induced liver injury

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QSG-7701 human hepatocytes form polarized acini in three-dimensional culture

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Identifiers

10.1007/S00204-014-1215-9

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

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