(Q39018278)

English

A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies

scientific article published on 6 March 2014

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies (English)

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

Bob van de Water

6

object named as

Bob van de Water

0 references

author name string

Sreenivasa C Ramaiahgari

1

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

Michiel W den Braver

2

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

Bram Herpers

3

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

Valeska Terpstra

4

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

Jan N M Commandeur

5

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

Bob van de Water

6

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

Leo S Price

7

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

publication date

6 March 2014

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

Archives of Toxicology

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

88

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

5

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

1083-1095

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

https://scigraph.springernature.com/pub.10.1007/s00204-014-1215-9

0 references

Use of sandwich-cultured human hepatocytes to predict biliary clearance of angiotensin II receptor blockers and HMG-CoA reductase inhibitors.

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1215-9

21 January 2018

Microtissue size and hypoxia in HTS with 3D cultures

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1215-9

21 January 2018

Molecular mechanisms of hepatocellular apoptosis induced by trovafloxacin-tumor necrosis factor-alpha interaction

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1215-9

21 January 2018

Investigation of testosterone, androstenone, and estradiol metabolism in HepG2 cells and primary culture pig hepatocytes and their effects on 17βHSD7 gene expression

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1215-9

21 January 2018

Characterization of testosterone 11 beta-hydroxylation catalyzed by human liver microsomal cytochromes P450.

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1215-9

21 January 2018

Hepatic transport mechanisms of cholyl-L-lysyl-fluorescein

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1215-9

21 January 2018

Nuclear receptors CAR and PXR: Molecular, functional, and biomedical aspects

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1215-9

21 January 2018

The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: a potential mechanism for hepatic adverse reactions

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1215-9

21 January 2018

Determination of drug toxicity using 3D spheroids constructed from an immortal human hepatocyte cell line.

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1215-9

21 January 2018

Diclofenac inhibits tumor necrosis factor-α-induced nuclear factor-κB activation causing synergistic hepatocyte apoptosis

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1215-9

21 January 2018

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1215-9

21 January 2018

Cytochrome P450s and other enzymes in drug metabolism and toxicity

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1215-9

21 January 2018

3D organotypic cultures of human HepaRG cells: a tool for in vitro toxicity studies

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1215-9

21 January 2018

Similarities and differences in the expression of drug-metabolizing enzymes between human hepatic cell lines and primary human hepatocytes

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1215-9

21 January 2018

Three-dimensional polarization sensitizes hepatocytes to Fas/CD95 apoptotic signalling.

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1215-9

21 January 2018

Multicellular tumor spheroids: an underestimated tool is catching up again.

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1215-9

21 January 2018

P-glycoprotein expression, localization, and function in sandwich-cultured primary rat and human hepatocytes: relevance to the hepatobiliary disposition of a model opioid peptide.

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1215-9

21 January 2018

Structure and function of the MRP2 (ABCC2) protein and its role in drug disposition

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1215-9

21 January 2018

A consecutive three alanine residue insertion mutant of human CAR: a novel CAR ligand screening system in HepG2 cells

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1215-9

21 January 2018

Method for generation of homogeneous multicellular tumor spheroids applicable to a wide variety of cell types

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1215-9

21 January 2018

Use of micropatterned cocultures to detect compounds that cause drug-induced liver injury in humans

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1215-9

21 January 2018

Transport mechanism and substrate specificity of human organic anion transporter 2 (hOat2 [SLC22A7]).

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1215-9

21 January 2018

New in vitro tools to study human constitutive androstane receptor (CAR) biology: discovery and comparison of human CAR inverse agonists

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1215-9

21 January 2018

Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation.

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1215-9

21 January 2018

Organotypic liver culture models: meeting current challenges in toxicity testing

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1215-9

21 January 2018

Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1215-9

21 January 2018

Enhanced bile canaliculi formation enabling direct recovery of biliary metabolites of hepatocytes in 3D collagen gel microcavities.

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1215-9

21 January 2018

3D organotypic HepaRG cultures as in vitro model for acute and repeated dose toxicity studies.

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1215-9

21 January 2018

Pregnane X receptor protects HepG2 cells from BaP-induced DNA damage

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1215-9

21 January 2018

Improved hepatocyte excretory function by immediate presentation of polarity cues.

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1215-9

21 January 2018

Valproic acid metabolism and its effects on mitochondrial fatty acid oxidation: a review

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1215-9

21 January 2018

Organic anion transporter (Slc22a) family members as mediators of toxicity

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1215-9

21 January 2018

Bioactivation of a toxic metabolite of valproic acid, (E)-2-propyl-2,4-pentadienoic acid, via glucuronidation. LC/MS/MS characterization of the GSH-glucuronide diconjugates

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1215-9

21 January 2018

Human liver cell spheroids in extended perfusion bioreactor culture for repeated-dose drug testing

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1215-9

21 January 2018

Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1215-9

21 January 2018

The maintenance and generation of membrane polarity in hepatocytes

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1215-9

21 January 2018

Predicting in vivo drug interactions from in vitro drug discovery data

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1215-9

21 January 2018

Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1215-9

21 January 2018

Cellular imaging predictions of clinical drug-induced liver injury

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1215-9

21 January 2018

QSG-7701 human hepatocytes form polarized acini in three-dimensional culture

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1215-9

21 January 2018

Evaluation of drug toxicity with hepatocytes cultured in a micro-space cell culture system

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1215-9

21 January 2018

Identifiers

10.1007/S00204-014-1215-9

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q39018278&oldid=1802514096"