(Q39020483)

8 September 2017

title

Perfusion seed cultures improve biopharmaceutical fed-batch production capacity and product quality (English)

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8 September 2017

William C Yang

1

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8 September 2017

Jiuyi Lu

2

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8 September 2017

Chris Kwiatkowski

3

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8 September 2017

Hang Yuan

4

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8 September 2017

Rashmi Kshirsagar

5

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8 September 2017

Thomas Ryll

6

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8 September 2017

Yao-Ming Huang

7

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8 September 2017

publication date

3 March 2014

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8 September 2017

published in

Biotechnology Progress

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8 September 2017

volume

30

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8 September 2017

issue

3

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8 September 2017

page(s)

616-625

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Methods in mammalian cell line engineering: from random mutagenesis to sequence-specific approaches.

8 September 2017

cites work

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CHO cells in biotechnology for production of recombinant proteins: current state and further potential

21 January 2018

1 reference

Cell culture processes for monoclonal antibody production

21 January 2018

1 reference

Impact of dynamic online fed-batch strategies on metabolism, productivity and N-glycosylation quality in CHO cell cultures.

21 January 2018

1 reference

Strategies for fed-batch cultivation of t-PA producing CHO cells: substitution of glucose and glutamine and rational design of culture medium

21 January 2018

1 reference

Process parameter shifting: Part I. Effect of DOT, pH, and temperature on the performance of Epo-Fc expressing CHO cells cultivated in controlled batch bioreactors

21 January 2018

1 reference

Process parameter shifting: Part II. Biphasic cultivation-A tool for enhancing the volumetric productivity of batch processes using Epo-Fc expressing CHO cells.

21 January 2018

1 reference

Effects of elevated pCO2 and osmolality on growth of CHO cells and production of antibody-fusion protein B1: a case study

21 January 2018

1 reference

Optimizing capacity utilization by large scale 3000 L perfusion in seed train bioreactors.

21 January 2018

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Case Study: an accelerated 8-day monoclonal antibody production process based on high seeding densities.

21 January 2018

1 reference

Acceptable changes in quality attributes of glycosylated biopharmaceuticals

21 January 2018

1 reference

Characterizing biological products and assessing comparability following manufacturing changes.

21 January 2018

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Potential of cell retention techniques for large-scale high-density perfusion culture of suspended mammalian cells

21 January 2018

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Integrated continuous production of recombinant therapeutic proteins.

21 January 2018

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Linear scale ultrafiltration

21 January 2018

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Maximizing productivity of CHO cell-based fed-batch culture using chemically defined media conditions and typical manufacturing equipment

21 January 2018

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Optimization and control of perfusion cultures using a viable cell probe and cell specific perfusion rates

21 January 2018

1 reference

Theory of protein folding: the energy landscape perspective

21 January 2018

1 reference

Enhanced production of monomeric interferon-beta by CHO cells through the control of culture conditions.

21 January 2018

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Protein folding and conformational stress in microbial cells producing recombinant proteins: a host comparative overview

21 January 2018

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Charge variants in IgG1: Isolation, characterization, in vitro binding properties and pharmacokinetics in rats

21 January 2018

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Strategies for improved dCO2 removal in large-scale fed-batch cultures

21 January 2018

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Insights into large-scale cell-culture reactors: II. Gas-phase mixing and CO₂ stripping

21 January 2018

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Decreased pCO(2) accumulation by eliminating bicarbonate addition to high cell-density cultures.

21 January 2018

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Effects of bubble–liquid two-phase turbulent hydrodynamics on cell damage in sparged bioreactor.

21 January 2018

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Physiology of cultured animal cells

21 January 2018

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Proliferation control strategies to improve productivity and survival during CHO based production culture : A summary of recent methods employed and the effects of proliferation control in product secreting CHO cell lines

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/BTPR.1884

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8 September 2017

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