(Q39021047)

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Frontline Science: Multiple cathepsins promote inflammasome-independent, particle-induced cell death during NLRP3-dependent IL-1β activation.

scientific article published on 13 January 2017

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scholarly article

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Europe PubMed Central

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9 April 2020

Frontline Science: Multiple cathepsins promote inflammasome-independent, particle-induced cell death during NLRP3-dependent IL-1β activation (English)

1 reference

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9 April 2020

inflammasome complex

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

4

object named as

Matthew Bogyo

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8 September 2017

author name string

Gregory M Orlowski

1

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9 April 2020

Shruti Sharma

2

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9 April 2020

Jeff D Colbert

3

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9 April 2020

Stephanie A Robertson

5

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9 April 2020

Hiroshi Kataoka

6

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9 April 2020

Francis K Chan

7

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9 April 2020

Kenneth L Rock

8

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9 April 2020

Matthew Bogyo

4

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9 April 2020

publication date

13 January 2017

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9 April 2020

Journal of Leukocyte Biology

1 reference

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9 April 2020

102

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9 April 2020

1

1 reference

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9 April 2020

7-17

1 reference

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9 April 2020

Cathepsin S required for normal MHC class II peptide loading and germinal center development

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective targeting of lysosomal cysteine proteases with radiolabeled electrophilic substrate analogs

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical characterization of human cathepsin X revealed that the enzyme is an exopeptidase, acting as carboxymonopeptidase or carboxydipeptidase

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal loss and brain atrophy in mice lacking cathepsins B and L

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CA-074, but not its methyl ester CA-074Me, is a selective inhibitor of cathepsin B within living cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Critical role for cathepsin B in mediating caspase-1-dependent interleukin-18 maturation and caspase-1-independent necrosis triggered by the microbial toxin nigericin

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular identification of a danger signal that alerts the immune system to dying cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cathepsin-dependent apoptosis triggered by supraoptimal activation of T lymphocytes: a possible mechanism of high dose tolerance

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sensitization to the lysosomal cell death pathway upon immortalization and transformation

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cathepsin B-independent abrogation of cell death by CA-074-OMe upstream of lysosomal breakdown

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cathepsin B inactivation attenuates hepatocyte apoptosis and liver damage in steatotic livers after cold ischemia-warm reperfusion injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effective tumor cell death by sigma-2 receptor ligand siramesine involves lysosomal leakage and oxidative stress.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dopamine-related and caspase-independent apoptosis in dopaminergic neurons induced by overexpression of human wild type or mutant alpha-synuclein

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gout-associated uric acid crystals activate the NALP3 inflammasome

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disease-associated mutations in CIAS1 induce cathepsin B-dependent rapid cell death of human THP-1 monocytic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

cFLIPL prevents TRAIL-induced apoptosis of hepatocellular carcinoma cells by inhibiting the lysosomal pathway of apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytosolic activation of cathepsins mediates parvovirus H-1-induced killing of cisplatin and TRAIL-resistant glioma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a key pathway required for the sterile inflammatory response triggered by dying cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disease-associated CIAS1 mutations induce monocyte death, revealing low-level mosaicism in mutation-negative cryopyrin-associated periodic syndrome patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

How dying cells alert the immune system to danger

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Nalp3 inflammasome is essential for the development of silicosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The NALP3 inflammasome is involved in the innate immune response to amyloid-beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cathepsins: key modulators of cell death and inflammatory responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Granulysin induces cathepsin B release from lysosomes of target tumor cells to attack mitochondria through processing of bid leading to Necroptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of cathepsin B in the processing and secretion of interleukin-1beta in chromogranin A-stimulated microglia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CA-074Me protection against anthrax lethal toxin

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Malarial hemozoin is a Nalp3 inflammasome activating danger signal

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NADPH oxidase NOX2 mediates rapid cellular oxidation following ATP stimulation of endotoxin-primed macrophages.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase 1-independent activation of interleukin-1beta in neutrophil-predominant inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple interleukin-1beta-converting enzymes contribute to inflammatory arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Listeria monocytogenes-infected human peripheral blood mononuclear cells produce IL-1beta, depending on listeriolysin O and NLRP3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lysosomal membrane permeabilization and cathepsin release is a Bax/Bak-dependent, amplifying event of apoptosis in fibroblasts and monocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of the cellular sensor that stimulates the inflammatory response to sterile cell death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In Vitro and In Vivo Studies of the Trypanocidal Properties of WRR-483 against Trypanosoma cruzi

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adenovirus membrane penetration activates the NLRP3 inflammasome.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pyroptosis: macrophage suicide exposes hidden invaders.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recognition of cytoplasmic RNA results in cathepsin-dependent inflammasome activation and apoptosis in human macrophages.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RIP3 mediates the embryonic lethality of caspase-8-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum amyloid A activates the NLRP3 inflammasome via P2X7 receptor and a cathepsin B-sensitive pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Non-canonical inflammasome activation targets caspase-11

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell death and infection: a double-edged sword for host and pathogen survival.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of ALZET® osmotic pump compatible solvent compositions to solubilize poorly soluble compounds for preclinical studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The IL-1-dependent sterile inflammatory response has a substantial caspase-1-independent component that requires cathepsin C.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammasomes and their roles in health and disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cathepsin-mediated necrosis controls the adaptive immune response by Th2 (T helper type 2)-associated adjuvants

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of lysosome rupture in controlling Nlrp3 signaling and necrotic cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

K⁺ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Improved quenched fluorescent probe for imaging of cysteine cathepsin activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Processes of sterile inflammation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial reactive oxygen species induces NLRP3-dependent lysosomal damage and inflammasome activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Danger-associated molecular patterns and danger signals in idiopathic pulmonary fibrosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A proteolytic cascade controls lysosome rupture and necrotic cell death mediated by lysosome-destabilizing adjuvants.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple Cathepsins Promote Pro-IL-1β Synthesis and NLRP3-Mediated IL-1β Activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Response to local inflammation of IL-1 beta-converting enzyme- deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholesterol crystals as an etiological factor in non-resolving chronic inflammation: an experimental study in guinea pigs

1 reference

https://pubmed.ncbi.nlm.nih.gov/28087651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1189/JLB.3HI0316-152R

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28087651%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28087651%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28087651%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

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