(Q39023951)

8 September 2017

1 reference

title

Bacterial proteases, untapped antimicrobial drug targets (English)

1 reference

8 September 2017

Elizabeth Culp

1

1 reference

PubMed ID

27899793

8 September 2017

Gerard D Wright

series ordinal

2

1 reference

8 September 2017

30 November 2016

1 reference

The Journal of Antibiotics

8 September 2017

1 reference

8 September 2017

70

1 reference

8 September 2017

4

1 reference

8 September 2017

366-377

1 reference

Creative Commons Attribution 4.0 International

8 September 2017

start time

30 November 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

exact match

https://scigraph.springernature.com/pub.10.1038/ja.2016.138

0 references

cites work

Antibacterial drug discovery in the resistance era.

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

A Complete Pathway Model for Lipid A Biosynthesis in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Roles of the membrane-reentrant β-hairpin-like loop of RseP protease in selective substrate cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Development of antivirulence compounds: a biochemical review

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Beyond Antibiotics: New Therapeutic Approaches for Bacterial Infections

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Serine protease mechanism and specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Irreversible inhibitors of serine, cysteine, and threonine proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

A unified mechanism for proteolysis and autocatalytic activation in the 20S proteasome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

HIV-1 protease: mechanism and drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Bacterial proteolytic complexes as therapeutic targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Emerging principles in protease-based drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Secretion, processing and activation of bacterial extracellular proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Something old, something new: revisiting natural products in antibiotic drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Proteases in bacterial pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Peptidyl boronates inhibit Salmonella enterica serovar Typhimurium Lon protease by a competitive ATP-dependent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Bacterial caseinolytic proteases as novel targets for antibacterial treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Inhibitors of Helicobacter pylori protease HtrA found by 'virtual ligand' screening combat bacterial invasion of epithelia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Inhibitors selective for mycobacterial versus human proteasomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Alternative roles of ClpX and ClpP in Staphylococcus aureus stress tolerance and virulence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Clp chaperones and proteases are central in stress survival, virulence and antibiotic resistance of Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

ClpP of Bacillus subtilis is required for competence development, motility, degradative enzyme synthesis, growth at high temperature and sporulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

ClpP: a structurally dynamic protease regulated by AAA+ proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

AAA+ chaperones and acyldepsipeptides activate the ClpP protease via conformational control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Adapting the machine: adaptor proteins for Hsp100/Clp and AAA+ proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Staphylococcus aureus ClpC is required for stress resistance, aconitase activity, growth recovery, and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

The ClpC ATPase of Listeria monocytogenes is a general stress protein required for virulence and promoting early bacterial escape from the phagosome of macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Stress-induced ClpP serine protease of Listeria monocytogenes is essential for induction of listeriolysin O-dependent protective immunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

walK and clpP mutations confer reduced vancomycin susceptibility in Staphylococcus aureus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

β-Lactam resistance in methicillin-resistant Staphylococcus aureus USA300 is increased by inactivation of the ClpXP protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Additional routes to Staphylococcus aureus daptomycin resistance as revealed by comparative genome sequencing, transcriptional profiling, and phenotypic studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Mycobacterium tuberculosis ClpP1 and ClpP2 function together in protein degradation and are required for viability in vitro and during infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Acyl depsipeptide (ADEP) resistance in Streptomyces

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Validation of the essential ClpP protease in Mycobacterium tuberculosis as a novel drug target

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Identifying vulnerable pathways in Mycobacterium tuberculosis by using a knockdown approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Genes required for mycobacterial growth defined by high density mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

The ClpP protease of Streptococcus pneumoniae modulates virulence gene expression and protects against fatal pneumococcal challenge

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

The ClpP serine protease is essential for the intracellular parasitism and virulence of Listeria monocytogenes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Beta-lactones as specific inhibitors of ClpP attenuate the production of extracellular virulence factors of Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Beta-lactones decrease the intracellular virulence of Listeria monocytogenes in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Antibacterial activity of and resistance to small molecule inhibitors of the ClpP peptidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Phenyl Esters Are Potent Inhibitors of Caseinolytic Protease P and Reveal a Stereogenic Switch for Deoligomerization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Dysregulation of bacterial proteolytic machinery by a new class of antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Crystal structure of Mycobacterium tuberculosis ClpP1P2 suggests a model for peptidase activation by AAA+ partner binding and substrate delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Development and Characterization of Potent Cyclic Acyldepsipeptide Analogues with Increased Antimicrobial Activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Acyldepsipeptide antibiotics induce the formation of a structured axial channel in ClpP: A model for the ClpX/ClpA-bound state of ClpP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Molecular determinants of complex formation between Clp/Hsp100 ATPases and the ClpP peptidase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

The antibiotic ADEP reprogrammes ClpP, switching it from a regulated to an uncontrolled protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

A Conformationally Constrained Cyclic Acyldepsipeptide Is Highly Effective in Mice Infected with Methicillin-Susceptible and -Resistant Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Activated ClpP kills persisters and eradicates a chronic biofilm infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Restriction of the conformational dynamics of the cyclic acyldepsipeptide antibiotics improves their antibacterial activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Fragment-Based Strategy for Investigating and Suppressing the Efflux of Bioactive Small Molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Diversity-oriented synthesis of cyclic acyldepsipeptides leads to the discovery of a potent antibacterial agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Total synthesis and antibacterial testing of the A54556 cyclic acyldepsipeptides isolated from Streptomyces hawaiiensis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Activators of cylindrical proteases as antimicrobials: identification and development of small molecule activators of ClpP protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

A simple fragment of cyclic acyldepsipeptides is necessary and sufficient for ClpP activation and antibacterial activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Examination of a Structural Model of Peptidomimicry by Cyclic Acyldepsipeptide Antibiotics in Their Interaction with the ClpP Peptidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Sclerotiamide: The First Non-Peptide-Based Natural Product Activator of Bacterial Caseinolytic Protease P.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Insights into Structural Network Responsible for Oligomerization and Activity of Bacterial Virulence Regulator Caseinolytic Protease P (ClpP) Protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Structural Basis of Mycobacterial Inhibition by Cyclomarin A

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

The cyclic peptide ecumicin targeting ClpC1 is active against Mycobacterium tuberculosis in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Lassomycin, a Ribosomally Synthesized Cyclic Peptide, Kills Mycobacterium tuberculosis by Targeting the ATP-Dependent Protease ClpC1P1P2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Improvement of the productivity of ecumicin, a novel anti-tuberculosis agent, from new Nonomuraea sp. MJM5123.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Total Synthesis of Cyclomarin A, a Marine Cycloheptapeptide with Anti-Tuberculosis and Anti-Malaria Activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Mitochondrial matrix proteases as novel therapeutic targets in malignancy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Loss of m-AAA protease in mitochondria causes complex I deficiency and increased sensitivity to oxidative stress in hereditary spastic paraplegia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

The proteasome of Mycobacterium tuberculosis is required for resistance to nitric oxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Distinct specificities of Mycobacterium tuberculosis and mammalian proteasomes for N-acetyl tripeptide substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

The Lon protease is essential for full virulence in Pseudomonas aeruginosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Oral immunization with ATP-dependent protease-deficient mutants protects mice against subsequent oral challenge with virulent Salmonella enterica serovar typhimurium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

The LonA Protease Regulates Biofilm Formation, Motility, Virulence, and the Type VI Secretion System in Vibrio cholerae

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

The Lon protease homologue LonA, not LonC, contributes to the stress tolerance and biofilm formation of Actinobacillus pleuropneumoniae

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Crystallography and mutagenesis point to an essential role for the N-terminus of human mitochondrial ClpP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Crystal structure of a bacterial signal peptidase in complex with a beta-lactam inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

The inhibition of type I bacterial signal peptidase: Biological consequences and therapeutic potential.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Initial efforts toward the optimization of arylomycins for antibiotic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Broadening the spectrum of β-lactam antibiotics through inhibition of signal peptidase type I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Antibiotic Adjuvants: Rescuing Antibiotics from Resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Structural basis of lipoprotein signal peptidase II action and inhibition by the antibiotic globomycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Myxobacterium-produced antibiotic TA (myxovirescin) inhibits type II signal peptidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

β-Lactams and β-Lactamase Inhibitors: An Overview

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Molecular features of the sortase enzyme family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Antiinfective therapy with a small molecule inhibitor of Staphylococcus aureus sortase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Designing inhibitors of anthrax toxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Clostridium difficile Toxins A and B: Insights into Pathogenic Properties and Extraintestinal Effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

A small-molecule antivirulence agent for treating Clostridium difficile infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

Recent Advances in Zinc Enzymology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

7 January 2021

The ATPase ClpX is conditionally involved in the morphological differentiation of Streptomyces lividans

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

7 January 2021

Clp ATPases are required for stress tolerance, intracellular replication and biofilm formation in Staphylococcus aureus

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

7 January 2021

Beta-lactones as privileged structures for the active-site labeling of versatile bacterial enzyme classes

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

7 January 2021

A β-lactone-based antivirulence drug ameliorates Staphylococcus aureus skin infections in mice

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

7 January 2021

Medicinal chemistry optimization of acyldepsipeptides of the enopeptin class antibiotics.

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

7 January 2021

Cyclomarins A−C, New Antiinflammatory Cyclic Peptides Produced by a Marine Bacterium (Streptomycessp.)

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

7 January 2021

Total chemical synthesis of lassomycin and lassomycin-amide

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

7 January 2021

Mechanism of action of globomycin

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

7 January 2021

Structure-activity relationships of globomycin analogues as antibiotics

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.138

7 January 2021

Sequence and structure of Clp P, the proteolytic component of the ATP-dependent Clp protease of Escherichia coli

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27899793

12 December 2020

inferred from PubMed ID database lookup

Inhibitors of bacterial signal peptidase: a series of 6-(substituted oxyethyl)penems.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27899793

12 December 2020

inferred from PubMed ID database lookup

The natural product cyclomarin kills Mycobacterium tuberculosis by targeting the ClpC1 subunit of the caseinolytic protease

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27899793

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/JA.2016.138

1 reference

PubMed ID

27899793

Dimensions Publication ID

8 September 2017

0 references

1 reference

PubMed ID

27899793