(Q39064401)

8 September 2017

Soluble forms of polyQ-expanded huntingtin rather than large aggregates cause endoplasmic reticulum stress (English)

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8 September 2017

endoplasmic reticulum

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2

F Ulrich Hartl

1 reference

8 September 2017

Julia Leitman

1

1 reference

PubMed ID

24217578

8 September 2017

Gerardo Z Lederkremer

series ordinal

3

1 reference

PubMed ID

24217578

8 September 2017

language of work or name

English

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publication date

1 January 2013

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8 September 2017

Nature Communications

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8 September 2017

4

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8 September 2017

2753

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https://scigraph.springernature.com/pub.10.1038/ncomms3753

8 September 2017

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cites work

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Molecular chaperones as modulators of polyglutamine protein aggregation and toxicity

21 January 2018

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Cellular toxicity of polyglutamine expansion proteins: mechanism of transcription factor deactivation

21 January 2018

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Neurodegenerative processes in Huntington's disease

21 January 2018

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The ubiquitin-proteasome pathway in Huntington's disease.

21 January 2018

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Is the ubiquitin-proteasome system impaired in Huntington's disease?

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS3753

Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3753

Huntingtin interacts with the cue domain of gp78 and inhibits gp78 binding to ubiquitin and p97/VCP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3753

Protein quality control, retention, and degradation at the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3753

Road to ruin: targeting proteins for degradation in the endoplasmic reticulum

21 January 2018

1 reference

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Rrs1 is involved in endoplasmic reticulum stress response in Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3753

Inhibition of endoplasmic reticulum stress counteracts neuronal cell death and protein aggregation caused by N-terminal mutant huntingtin proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3753

Endoplasmic reticulum dysfunction in neurological disease

21 January 2018

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Converging pathways in the occurrence of endoplasmic reticulum (ER) stress in Huntington's disease

21 January 2018

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Formation and toxicity of soluble polyglutamine oligomers in living cells

21 January 2018

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Soluble polyglutamine oligomers formed prior to inclusion body formation are cytotoxic

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3753

Single neuron ubiquitin-proteasome dynamics accompanying inclusion body formation in huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3753

Acute polyglutamine expression in inducible mouse model unravels ubiquitin/proteasome system impairment and permanent recovery attributable to aggregate formation.

21 January 2018

1 reference

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A novel quality control compartment derived from the endoplasmic reticulum

21 January 2018

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Membrane-bound versus secreted forms of human asialoglycoprotein receptor subunits. Role of a juxtamembrane pentapeptide

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS3753

PERK-dependent compartmentalization of ERAD and unfolded protein response machineries during ER stress

21 January 2018

1 reference

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The unfolded protein response: from stress pathway to homeostatic regulation

21 January 2018

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A transgenic mouse model for monitoring endoplasmic reticulum stress

21 January 2018

1 reference

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VCP/p97 in abnormal protein aggregates, cytoplasmic vacuoles, and cell death, phenotypes relevant to neurodegeneration

21 January 2018

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Molecular chaperones in protein folding and proteostasis

21 January 2018

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Indirect inhibition of 26S proteasome activity in a cellular model of Huntington's disease

21 January 2018

1 reference

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Chaperonin TRiC promotes the assembly of polyQ expansion proteins into nontoxic oligomers.

21 January 2018

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Large α-synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking

21 January 2018

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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

21 January 2018

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Protein folding stress in neurodegenerative diseases: a glimpse into the ER.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3753

Valosin-containing protein gene mutations: cellular phenotypes relevant to neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3753

Bypass of glycan-dependent glycoprotein delivery to ERAD by up-regulated EDEM1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3753

Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3753

The influence of huntingtin protein size on nuclear localization and cellular toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3753

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3753

21 January 2018

Identifiers

DOI

10.1038/NCOMMS3753

1 reference

8 September 2017

0 references

1 reference

PubMed ID

24217578