(Q39070125)

8 September 2017

title

ARF triggers senescence in Brca2-deficient cells by altering the spectrum of p53 transcriptional targets (English)

1 reference

8 September 2017

1

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3 June 2020

Panagiotis Kotsantis

3

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3 June 2020

Peter Bouwman

5

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3 June 2020

Gonzalo Gómez-López

9

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3 June 2020

David G. Pisano

10

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3 June 2020

author name string

Jose Miguel Escandell

2

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3 June 2020

Natsuko Suwaki

4

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3 June 2020

Sophie Badie

6

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3 June 2020

Cecilia Folio

7

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3 June 2020

Jos Jonkers

11

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3 June 2020

Madalena Tarsounas

12

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3 June 2020

Javier Benitez

8

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3 June 2020

language of work or name

English

0 references

publication date

1 January 2013

1 reference

8 September 2017

published in

Nature Communications

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3 June 2020

volume

4

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3 June 2020

page(s)

2697

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Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all.

3 June 2020

cites work

1 reference

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Methylation silencing and mutations of the p14ARF and p16INK4a genes in colon cancer

21 January 2018

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Genetic alterations of the p14ARF -hdm2-p53 regulatory pathway in breast carcinoma.

21 January 2018

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Regulating the p53 pathway: in vitro hypotheses, in vivo veritas

21 January 2018

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Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

21 January 2018

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p53 ubiquitination: Mdm2 and beyond

21 January 2018

1 reference

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Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

21 January 2018

1 reference

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The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

21 January 2018

1 reference

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p53-Dependent and -independent functions of the Arf tumor suppressor

21 January 2018

1 reference

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Genomic instability--an evolving hallmark of cancer

21 January 2018

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Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

21 January 2018

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An oncogene-induced DNA damage model for cancer development

21 January 2018

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Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications

21 January 2018

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Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11.

21 January 2018

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Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis

21 January 2018

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Mouse models of BRCA1 and BRCA2 deficiency: past lessons, current understanding and future prospects

21 January 2018

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Linking the cellular functions of BRCA genes to cancer pathogenesis and treatment

21 January 2018

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Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.

21 January 2018

1 reference

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Self-excising retroviral vectors encoding the Cre recombinase overcome Cre-mediated cellular toxicity

21 January 2018

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Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3697

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3697

Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3697

ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

21 January 2018

1 reference

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DNA end resection--unraveling the tail

21 January 2018

1 reference

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BRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair

21 January 2018

1 reference

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A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex

21 January 2018

1 reference

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Molecular views of recombination proteins and their control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3697

BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3697

Discovery of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3697

Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATR

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3697

Combining ATR suppression with oncogenic Ras synergistically increases genomic instability, causing synthetic lethality or tumorigenesis in a dosage-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3697

Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3697

Blinded by the Light: The Growing Complexity of p53

21 January 2018

1 reference

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CDK inhibitors: positive and negative regulators of G1-phase progression

21 January 2018

1 reference

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Dual-specificity MAP kinase phosphatases (MKPs) and cancer

21 January 2018

1 reference

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Targeting dual-specificity phosphatases: manipulating MAP kinase signalling and immune responses.

21 January 2018

1 reference

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Truncated BRCA2 is cytoplasmic: implications for cancer-linked mutations

21 January 2018

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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

21 January 2018

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Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

21 January 2018

1 reference

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Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3697

21 January 2018

Modes of p53 regulation

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3697

The pathological response to DNA damage does not contribute to p53-mediated tumour suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3697

Brca2 deficiency does not impair mammary epithelium development but promotes mammary adenocarcinoma formation in p53(+/-) mutant mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3697

Divorcing ARF and p53: an unsettled case

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3697

Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3697

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3697

Signal integration by JNK and p38 MAPK pathways in cancer development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3697

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3697

Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3697

Induction of senescence by oncogenic Ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3697

Telomere maintenance requires the RAD51D recombination/repair protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3697

Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3697

Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3697

Multiple roles for MRE11 at uncapped telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3697

5'-UTR RNA G-quadruplexes: translation regulation and targeting

21 January 2018

1 reference

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3697

Replicon clusters are stable units of chromosome structure: evidence that nuclear organization contributes to the efficient activation and propagation of S phase in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3697

Use of within-array replicate spots for assessing differential expression in microarray experiments

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3697

BRCA2-dependent and independent formation of RAD51 nuclear foci.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3697

The breast cancer susceptibility gene BRCA2 is required for the maintenance of telomere homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3697

Clonogenic assay of cells in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3697

Telomeres, stem cells, senescence, and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3697

Promoter hypermethylation and homozygous deletion of the p14ARF and p16INK4a genes in oligodendrogliomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3697

7 January 2021

Telomeres, stem cells, senescence, and cancer

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3697

7 January 2021

p53 mutations in BRCA1-associated familial breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3697

7 January 2021

A third-generation lentivirus vector with a conditional packaging system

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3697

7 January 2021

Model-based variance-stabilizing transformation for Illumina microarray data.

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3697

7 January 2021

Identifiers

DOI

10.1038/NCOMMS3697

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24162189%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

3 June 2020

ADS bibcode

2013NatCo...4.2697C

0 references

1047103985

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24162189%20AND%20SRC:MED&resulttype=core&format=json