(Q39085330)

English

Novel insights into pancreatic β-cell glucolipotoxicity from real-time functional analysis of mitochondrial energy metabolism in INS-1E insulinoma cells

scientific article published on December 2013

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scholarly article

1 reference

Europe PubMed Central

8 September 2017

Novel insights into pancreatic β-cell glucolipotoxicity from real-time functional analysis of mitochondrial energy metabolism in INS-1E insulinoma cells (English)

1 reference

Europe PubMed Central

8 September 2017

1 reference

based on heuristic

inferred from title

Charles Affourtit

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Charles Affourtit

2

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author name string

Jonathan Barlow

1

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Europe PubMed Central

8 September 2017

language of work or name

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publication date

1 December 2013

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Europe PubMed Central

8 September 2017

number of pages

10

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Biochemical Journal

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Europe PubMed Central

8 September 2017

456

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Europe PubMed Central

8 September 2017

3

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Europe PubMed Central

8 September 2017

417-426

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Europe PubMed Central

8 September 2017

Obesity and type 2 diabetes: which patients are at risk?

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131002

21 January 2018

Mechanisms of disease:Molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131002

21 January 2018

Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131002

21 January 2018

Islet beta cell failure in type 2 diabetes

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131002

21 January 2018

Glucolipotoxicity of the pancreatic beta cell.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131002

21 January 2018

Life and death decisions of the pancreatic beta-cell: the role of fatty acids

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131002

21 January 2018

Unsaturated fatty acids as cytoprotective agents in the pancreatic beta-cell

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131002

21 January 2018

Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in beta-cell adaptation and failure in the etiology of diabetes

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131002

21 January 2018

Role of pancreatic β-cell death and cell death-associated inflammation in diabetes

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131002

21 January 2018

Alterations in microRNA expression contribute to fatty acid-induced pancreatic beta-cell dysfunction

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131002

21 January 2018

Coordinate changes in histone modifications, mRNA levels, and metabolite profiles in clonal INS-1 832/13 β-cells accompany functional adaptations to lipotoxicity

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131002

21 January 2018

Role of inflammatory mechanisms in pathogenesis of type 2 diabetes mellitus.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131002

21 January 2018

Palmitate modulates the early steps of insulin signalling pathway in pancreatic islets

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131002

21 January 2018

Reactive oxygen species and uncoupling protein 2 in pancreatic β-cell function.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131002

21 January 2018

Endoplasmic reticulum stress, obesity and diabetes

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131002

21 January 2018

Mitochondrial dysfunction and type 2 diabetes

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131002

21 January 2018

Glycerolipid/free fatty acid cycle and islet β-cell function in health, obesity and diabetes

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131002

21 January 2018

Lipotoxicity: why do saturated fatty acids cause and monounsaturates protect against it?

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131002

21 January 2018

Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131002

21 January 2018

Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131002

21 January 2018

Uncoupling protein-2 attenuates glucose-stimulated insulin secretion in INS-1E insulinoma cells by lowering mitochondrial reactive oxygen species

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131002

21 January 2018

Beta-cell uncoupling protein 2 regulates reactive oxygen species production, which influences both insulin and glucagon secretion

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131002

21 January 2018

Mitochondrial dysfunction in pancreatic beta-cells in Type 2 diabetes

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131002

21 January 2018

Assessing mitochondrial dysfunction in cells.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131002

21 January 2018

Tight coupling between glucose and mitochondrial metabolism in clonal beta-cells is required for robust insulin secretion

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131002

21 January 2018

Reactive oxygen species as a signal in glucose-stimulated insulin secretion

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131002

21 January 2018

Measuring mitochondrial bioenergetics in INS-1E insulinoma cells

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131002

21 January 2018

Glucose Sensitivity and Metabolism-Secretion Coupling Studied during Two-Year Continuous Culture in INS-1E Insulinoma Cells

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131002

21 January 2018

Fatty acid-specific fluorescent probes and their use in resolving mixtures of unbound free fatty acids in equilibrium with albumin

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131002

21 January 2018

Measuring mitochondrial uncoupling protein-2 level and activity in insulinoma cells.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131002

21 January 2018

Nutrient-secretion coupling in the pancreatic islet beta-cell: recent advances

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131002

21 January 2018

Stronger control of ATP/ADP by proton leak in pancreatic beta-cells than skeletal muscle mitochondria

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131002

21 January 2018

Selective fluorescent imaging of superoxide in vivo using ethidium-based probes

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131002

21 January 2018

Insights into the critical role of NADPH oxidase(s) in the normal and dysregulated pancreatic beta cell

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131002

21 January 2018

Glucose, palmitate and pro-inflammatory cytokines modulate production and activity of a phagocyte-like NADPH oxidase in rat pancreatic islets and a clonal beta cell line

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131002

21 January 2018

The Randle cycle revisited: a new head for an old hat.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131002

21 January 2018

Etomoxir-induced partial carnitine palmitoyltransferase-I (CPT-I) inhibition in vivo does not alter cardiac long-chain fatty acid uptake and oxidation rates.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131002

21 January 2018

Activation of the ATP-sensitive K+ channel by long chain acyl-CoA. A role in modulation of pancreatic beta-cell glucose sensitivity.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131002

21 January 2018

The inhibitors of protein acylation, cerulenin and tunicamycin, increase voltage-dependent Ca(2+) currents in the insulin-secreting INS 832/13 cell

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131002

21 January 2018

Chronic palmitate exposure inhibits insulin secretion by dissociation of Ca(2+) channels from secretory granules

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131002

21 January 2018

A novel high-throughput assay for islet respiration reveals uncoupling of rodent and human islets

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131002

21 January 2018

Mechanisms involved in the cytotoxic and cytoprotective actions of saturated versus monounsaturated long-chain fatty acids in pancreatic beta-cells

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131002

21 January 2018

Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the beta-cell line INS-1.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131002

21 January 2018

Palmitate-induced changes in protein expression of insulin secreting INS-1E cells.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131002

21 January 2018

Triglyceride accumulation protects against fatty acid-induced lipotoxicity

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131002

21 January 2018

Acute effects of fatty acids on insulin secretion from rat and human islets of Langerhans

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131002

21 January 2018

Identifiers

10.1042/BJ20131002

1 reference

Europe PubMed Central

8 September 2017

1 reference

Europe PubMed Central

8 September 2017

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