(Q39182810)

English

Coordinate changes in histone modifications, mRNA levels, and metabolite profiles in clonal INS-1 832/13 β-cells accompany functional adaptations to lipotoxicity

scientific article published on 8 March 2013

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scholarly article

1 reference

Europe PubMed Central

9 September 2017

Coordinate changes in histone modifications, mRNA levels, and metabolite profiles in clonal INS-1 832/13 β-cells accompany functional adaptations to lipotoxicity (English)

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Europe PubMed Central

9 September 2017

object named as

Siri Malmgren

1

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Peter Spégel

2

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object named as

Charlotte Ling

9

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object named as

Hindrik Mulder

8

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author name string

Anders P H Danielsson

3

1 reference

Europe PubMed Central

9 September 2017

Cecilia L Nagorny

4

1 reference

Europe PubMed Central

9 September 2017

Lotta E Andersson

5

1 reference

Europe PubMed Central

9 September 2017

Marloes Dekker Nitert

6

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Europe PubMed Central

9 September 2017

Martin Ridderstråle

7

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Europe PubMed Central

9 September 2017

language of work or name

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publication date

8 March 2013

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Europe PubMed Central

9 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

9 September 2017

288

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Europe PubMed Central

9 September 2017

17

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Europe PubMed Central

9 September 2017

11973-11987

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Europe PubMed Central

9 September 2017

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3636884/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

NIH Image to ImageJ: 25 years of image analysis

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10 September 2017

Chromatin modifications associated with diabetes

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Increased DNA methylation and decreased expression of PDX-1 in pancreatic islets from patients with type 2 diabetes

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10 September 2017

DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients

1 reference

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10 September 2017

Glycemic memory

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Overexpression of Insig-1 protects β cell against glucolipotoxicity via SREBP-1c

1 reference

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Assessing mitochondrial dysfunction in cells.

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10 September 2017

Signals and combinatorial functions of histone modifications

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A Method to Study the Epigenetic Chromatin States of Rare Hematopoietic Stem and Progenitor Cells; MiniChIP-Chip

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Lipid-induced pancreatic β-cell dysfunction: focus on in vivo studies

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10 September 2017

Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA(1c) levels in human pancreatic islets

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Expression and function of Set7/9 in pancreatic islets

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10 September 2017

Genome-wide analysis of histone modifications in human pancreatic islets

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10 September 2017

Epigenetics: a molecular link between environmental factors and type 2 diabetes

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10 September 2017

Tight coupling between glucose and mitochondrial metabolism in clonal beta-cells is required for robust insulin secretion

1 reference

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10 September 2017

Linking DNA methylation and histone modification: patterns and paradigms

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10 September 2017

Regulation of insulin secretion: a matter of phase control and amplitude modulation

1 reference

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10 September 2017

Methyltransferase Set7/9 maintains transcription and euchromatin structure at islet-enriched genes

1 reference

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10 September 2017

Metabolic cycling in control of glucose-stimulated insulin secretion

1 reference

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10 September 2017

Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion

1 reference

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10 September 2017

Glucolipotoxicity: fuel excess and beta-cell dysfunction.

1 reference

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10 September 2017

High-resolution profiling of histone methylations in the human genome

1 reference

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10 September 2017

Beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment

1 reference

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10 September 2017

Chromatin modifications and their function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636884

10 September 2017

Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome

1 reference

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10 September 2017

Fatty acid signaling in the beta-cell and insulin secretion

1 reference

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10 September 2017

1 reference

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10 September 2017

TM4 microarray software suite

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10 September 2017

The diverse functions of histone lysine methylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636884

10 September 2017

Genomic maps and comparative analysis of histone modifications in human and mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636884

10 September 2017

Metabolic memory in diabetes--focus on insulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636884

10 September 2017

The malate-aspartate NADH shuttle member Aralar1 determines glucose metabolic fate, mitochondrial activity, and insulin secretion in beta cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636884

10 September 2017

Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636884

10 September 2017

Histones and histone modifications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636884

10 September 2017

Biochemical mechanism of lipid-induced impairment of glucose-stimulated insulin secretion and reversal with a malate analogue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636884

10 September 2017

Chronic effects of fatty acids on pancreatic beta-cell function: new insights from functional genomics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636884

10 September 2017

The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus

2 references

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10 September 2017

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21 August 2018

Exploration, normalization, and summaries of high density oligonucleotide array probe level data

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10 September 2017

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10 September 2017

Genetic manipulations of fatty acid metabolism in beta-cells are associated with dysregulated insulin secretion.

1 reference

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10 September 2017

Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in beta-cell adaptation and failure in the etiology of diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636884

10 September 2017

Expression profiling of palmitate- and oleate-regulated genes provides novel insights into the effects of chronic lipid exposure on pancreatic beta-cell function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636884

10 September 2017

Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails

1 reference

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10 September 2017

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10 September 2017

Differentiation of glucose toxicity from beta cell exhaustion during the evolution of defective insulin gene expression in the pancreatic islet cell line, HIT-T15

1 reference

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10 September 2017

Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships

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10 September 2017

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10 September 2017

Metabolomic analyses reveal profound differences in glycolytic and tricarboxylic acid cycle metabolism in glucose-responsive and -unresponsive clonal β-cell lines

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14 September 2017

Silencing of the mitochondrial NADH shuttle component aspartate-glutamate carrier AGC1/Aralar1 in INS-1E cells and rat islets.

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14 September 2017

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14 September 2017

Limited mitochondrial permeabilization is an early manifestation of palmitate-induced lipotoxicity in pancreatic beta-cells

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14 September 2017

Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis

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14 September 2017

Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress

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14 September 2017

Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle

1 reference

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14 September 2017

Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion

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25 September 2017

Lipid rather than glucose metabolism is implicated in altered insulin secretion caused by oleate in INS-1 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636884

25 September 2017

Glucose rapidly and reversibly decreases INS-1 cell insulin gene transcription via decrements in STF-1 and C1 activator transcription factor activity

1 reference

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25 September 2017

Chronic effect of fatty acids on insulin release is not through the alteration of glucose metabolism in a pancreatic beta-cell line (beta HC9).

1 reference

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25 September 2017

Malonyl-CoA and long chain acyl-CoA esters as metabolic coupling factors in nutrient-induced insulin secretion

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25 September 2017

The Influence of γ-Aminobutyric Acid on Hormone Release by the Mouse and Rat Endocrine Pancreas*

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25 September 2017

Redox control of exocytosis: regulatory role of NADPH, thioredoxin, and glutaredoxin

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15 June 2018

Voltage-activated calcium and potassium currents in human pancreatic beta-cells

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15 June 2018

Functional redundancy of mitochondrial enoyl-CoA isomerases in the oxidation of unsaturated fatty acids.

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21 August 2018

Glucolipotoxicity alters lipid partitioning and causes mitochondrial dysfunction, cholesterol, and ceramide deposition and reactive oxygen species production in INS832/13 ss-cells

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21 August 2018

Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density.

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21 August 2018

Cholesterol accumulation and diabetes in pancreatic beta-cell-specific SREBP-2 transgenic mice: a new model for lipotoxicity

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21 August 2018

Hormone-sensitive lipase deficiency in mouse islets abolishes neutral cholesterol ester hydrolase activity but leaves lipolysis, acylglycerides, fat oxidation, and insulin secretion intact

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21 August 2018

Predominant role of reduced beta-cell sensitivity to glucose over insulin resistance in impaired glucose tolerance

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21 August 2018

Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated.

1 reference

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21 August 2018

Increased expression of GAD65 and GABA in pancreatic beta-cells impairs first-phase insulin secretion.

1 reference

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21 August 2018

Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis.

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21 August 2018

A novel germline inactivating mutation in the CASR gene in an Italian kindred affected by familial hypocalciuric hypercalcemia

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppressive effect of GABA on insulin secretion from the pancreatic beta-cells in the rat

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A 48-hour lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and B cell oxidation through a process likely coupled to fatty acid oxidation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23476019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate is not a messenger in insulin secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/23476019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sodium palmitate induces partial mitochondrial uncoupling and reactive oxygen species in rat pancreatic islets in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/23476019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M112.422527

1 reference

Europe PubMed Central

9 September 2017

1 reference

Europe PubMed Central

9 September 2017

1 reference

Europe PubMed Central

9 September 2017

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