(Q39095721)

9 September 2017

Human tissues in a dish: The research and ethical implications of organoid technology (English)

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9 September 2017

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1

Annelien L Bredenoord

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9 September 2017

3

Juergen A Knoblich

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9 September 2017

Hans Clevers

2

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PubMed ID

28104841

9 September 2017

language of work or name

English

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publication date

1 January 2017

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9 September 2017

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9 September 2017

355

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9 September 2017

6322

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Organogenesis in a dish: modeling development and disease using organoid technologies

9 September 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF9414

Organoids as an in vitro model of human development and disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF9414

Organoids as Models for Neoplastic Transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF9414

Organoid Models of Human Gastrointestinal Development and Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF9414

Human stem cell-based disease modeling: prospects and challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF9414

A proposed definition of regenerative medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF9414

Animal Experiments in Biomedical Research: A Historical Perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF9414

Successful therapies for Alzheimer's disease: why so many in animal models and none in humans?

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF9414

Prospective derivation of a living organoid biobank of colorectal cancer patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF9414

Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF9414

The ethics of animal research. Talking Point on the use of animals in scientific research

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF9414

Bioengineering approaches to guide stem cell-based organogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF9414

Acetate mediates a microbiome-brain-β-cell axis to promote metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF9414

Ethics and refinement in animal research.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF9414

Neurogenic radial glia in the outer subventricular zone of human neocortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF9414

Expression Analysis Highlights AXL as a Candidate Zika Virus Entry Receptor in Neural Stem Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF9414

Dealing with uncertainties: ethics of prenatal diagnosis and preimplantation genetic diagnosis to prevent mitochondrial disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF9414

Ethics of mitochondrial gene replacement: from bench to bedside.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF9414

Embryology policy: Revisit the 14-day rule

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF9414

Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF9414

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF9414

Zika Virus Depletes Neural Progenitors in Human Cerebral Organoids through Activation of the Innate Immune Receptor TLR3

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF9414

The Brazilian Zika virus strain causes birth defects in experimental models

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF9414

Organoid biobanking: identifying the ethics: Organoids revive old and raise new ethical challenges for basic research and therapeutic use.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF9414

Self-organization of the in vitro attached human embryo

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF9414

Self-organization of the human embryo in the absence of maternal tissues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF9414

Big Data in medical research and EU data protection law: challenges to the consent or anonymise approach.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF9414

A functional CFTR assay using primary cystic fibrosis intestinal organoids

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF9414

Inclusion of residual tissue in biobanks: opt-in or opt-out?

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF9414

Drug discovery through stem cell-based organoid models

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF9414

Production of 3-D Airway Organoids From Primary Human Airway Basal Cells and Their Use in High-Throughput Screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF9414

Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5⁺ stem cell.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF9414

Long-term culture of genome-stable bipotent stem cells from adult human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF9414

Generation and characterization of rat liver stem cell lines and their engraftment in a rat model of liver failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF9414

Organoid models of human and mouse ductal pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF9414

One Size Fits All?: Ethical Considerations for Examining Efficacy in First-in-Human Pluripotent Stem Cell Studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF9414

The meaning of translational research and why it matters

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF9414

Societal impacts of regenerative medicine: reflections on the views of orthopedic professionals

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF9414

Stem cell trials for cardiovascular medicine: ethical rationale

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF9414

Ethics, ambiguity aversion, and the review of complex translational clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF9414

Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF9414

SCIENTIFIC COMMUNITY. Confronting stem cell hype

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF9414

The singapore statement on research integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF9414

Critical analysis of 3-D organoid in vitro cell culture models for high-throughput drug candidate toxicity assessments

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF9414

From consent to institutions: designing adaptive governance for genomic biobanks

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF9414

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF9414

21 January 2018

Identifiers

DOI

10.1126/SCIENCE.AAF9414

1 reference

9 September 2017

1 reference

PubMed ID

28104841