(Q39102364)

9 September 2017

Epithelial-mesenchymal transition leads to crizotinib resistance in H2228 lung cancer cells with EML4-ALK translocation (English)

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9 September 2017

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Hyeong Ryul Kim

1

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9 September 2017

Woo Sung Kim

2

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9 September 2017

Yun Jung Choi

3

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9 September 2017

Chang Min Choi

4

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9 September 2017

Jin Kyung Rho

5

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9 September 2017

Jae Cheol Lee

6

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9 September 2017

20 August 2013

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9 September 2017

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9 September 2017

7

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9 September 2017

6

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9 September 2017

1093-1102

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describes a project that uses

9 September 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5528442/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Targeted inhibition of the molecular chaperone Hsp90 overcomes ALK inhibitor resistance in non-small cell lung cancer

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Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer

9 September 2017

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Cancer stem cells and epithelial-mesenchymal transition: concepts and molecular links

9 September 2017

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KLC1-ALK: a novel fusion in lung cancer identified using a formalin-fixed paraffin-embedded tissue only

9 September 2017

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Mechanisms of acquired crizotinib resistance in ALK-rearranged lung Cancers

9 September 2017

1 reference

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Epithelial-mesenchymal transition, cancer stem cells and treatment resistance

9 September 2017

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Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer.

9 September 2017

1 reference

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ROS1 rearrangements define a unique molecular class of lung cancers

9 September 2017

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A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors

9 September 2017

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Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK.

9 September 2017

1 reference

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Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors

9 September 2017

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EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors.

9 September 2017

1 reference

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Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer

9 September 2017

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Inhibition of ALK, PI3K/MEK, and HSP90 in murine lung adenocarcinoma induced by EML4-ALK fusion oncogene

9 September 2017

1 reference

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The epithelial-mesenchymal transition (EMT) phenomenon

9 September 2017

1 reference

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EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

9 September 2017

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Epithelial-mesenchymal transition in cancer development and its clinical significance

9 September 2017

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Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK

9 September 2017

1 reference

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The basics of epithelial-mesenchymal transition

9 September 2017

1 reference

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KIF5B-ALK, a novel fusion oncokinase identified by an immunohistochemistry-based diagnostic system for ALK-positive lung cancer

9 September 2017

1 reference

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A mouse model for EML4-ALK-positive lung cancer

9 September 2017

1 reference

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Critical regulation of TGFbeta signaling by Hsp90

9 September 2017

1 reference

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Inhibition of Hsp90 down-regulates mutant epidermal growth factor receptor (EGFR) expression and sensitizes EGFR mutant tumors to paclitaxel

9 September 2017

1 reference

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Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma

9 September 2017

1 reference

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Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer

9 September 2017

1 reference

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Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528442

EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528442

Bcr-Abl kinase domain mutations and the unsettled problem of Bcr-AblT315I: looking into the future of controlling drug resistance in chronic myeloid leukemia.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528442

The epithelial-mesenchymal transition: new insights in signaling, development, and disease

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528442

TGF-beta and epithelial-to-mesenchymal transitions

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528442

TGF-beta1 induces human alveolar epithelial to mesenchymal cell transition (EMT)

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528442

Smad-dependent and Smad-independent pathways in TGF-beta family signalling

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528442

TGFbeta signaling in growth control, cancer, and heritable disorders

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528442

Controlling TGF-beta signaling

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528442

Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528442

Clinical and molecular evidences of epithelial to mesenchymal transition in acquired resistance to EGFR-TKIs

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528442

Coexpression of Oct4 and Nanog enhances malignancy in lung adenocarcinoma by inducing cancer stem cell-like properties and epithelial-mesenchymal transdifferentiation.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528442

Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528442

Epithelial to mesenchymal transition derived from repeated exposure to gefitinib determines the sensitivity to EGFR inhibitors in A549, a non-small cell lung cancer cell line

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528442

Epithelial versus mesenchymal phenotype determines in vitro sensitivity and predicts clinical activity of erlotinib in lung cancer patients

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528442

Epithelial to mesenchymal transition is a determinant of sensitivity of non-small-cell lung carcinoma cell lines and xenografts to epidermal growth factor receptor inhibition

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528442

Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528442

ALK gene rearrangements: a new therapeutic target in a molecularly defined subset of non-small cell lung cancer.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528442

The EML4-ALK fusion gene is involved in various histologic types of lung cancers from nonsmokers with wild-type EGFR and KRAS.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528442

Inherited susceptibility to lung cancer may be associated with the T790M drug resistance mutation in EGFR.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528442

Remarkable tumor response to crizotinib in a 14-year-old girl with ALK-positive non-small-cell lung cancer.

21 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1016%2FJ.MOLONC.2013.08.001

10.1016/J.MOLONC.2013.08.001

21 January 2018

Identifiers

DOI

1 reference

9 September 2017

1 reference

9 September 2017

PubMed publication ID

23993685

1 reference