(Q39148813)

English

CBL linker region and RING finger mutations lead to enhanced granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling via elevated levels of JAK2 and LYN.

scientific article published on 21 May 2013

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

9 September 2017

CBL linker region and RING finger mutations lead to enhanced granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling via elevated levels of JAK2 and LYN. (English)

1 reference

Europe PubMed Central

PMC publication ID

9 September 2017

author name string

Mojib Javadi

1

1 reference

Europe PubMed Central

PMC publication ID

9 September 2017

Terri D Richmond

2

1 reference

Europe PubMed Central

PMC publication ID

9 September 2017

Kai Huang

3

1 reference

Europe PubMed Central

PMC publication ID

9 September 2017

Dwayne L Barber

4

1 reference

Europe PubMed Central

PMC publication ID

9 September 2017

language of work or name

0 references

publication date

21 May 2013

1 reference

Europe PubMed Central

PMC publication ID

9 September 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PMC publication ID

9 September 2017

288

1 reference

Europe PubMed Central

PMC publication ID

9 September 2017

27

1 reference

Europe PubMed Central

PMC publication ID

9 September 2017

19459-19470

1 reference

Europe PubMed Central

PMC publication ID

9 September 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3707649/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl

1 reference

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Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells

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Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia

1 reference

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Novel oncogenic mutations of CBL in human acute myeloid leukemia that activate growth and survival pathways depend on increased metabolism

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1 reference

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Mutations of an E3 ubiquitin ligase c-Cbl but not TET2 mutations are pathogenic in juvenile myelomonocytic leukemia

1 reference

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Mutations of e3 ubiquitin ligase cbl family members constitute a novel common pathogenic lesion in myeloid malignancies.

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Ubiquitination and degradation of the thrombopoietin receptor c-Mpl.

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10 September 2017

Mutations in CBL occur frequently in juvenile myelomonocytic leukemia

1 reference

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10 September 2017

Juvenile myelomonocytic leukemia: a report from the 2nd International JMML Symposium

1 reference

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10 September 2017

The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation

1 reference

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10 September 2017

Juvenile myelomonocytic leukemia and chronic myelomonocytic leukemia.

1 reference

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10 September 2017

c-Cbl-dependent monoubiquitination and lysosomal degradation of gp130

1 reference

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Growth factor pleiotropy is controlled by a receptor Tyr/Ser motif that acts as a binary switch

1 reference

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The mutational spectrum of PTPN11 in juvenile myelomonocytic leukemia and Noonan syndrome/myeloproliferative disease

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10 September 2017

Cbl-mediated degradation of Lyn and Fyn induced by constitutive fibroblast growth factor receptor-2 activation supports osteoblast differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707649

10 September 2017

Regulation of ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations

1 reference

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Regulation of myeloid development and function by colony stimulating factors.

1 reference

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10 September 2017

Negative regulation of Lyn protein-tyrosine kinase by c-Cbl ubiquitin-protein ligase in Fc epsilon RI-mediated mast cell activation

1 reference

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10 September 2017

Repression of c-Cbl leads to enhanced G-CSF Jak-STAT signaling without increased cell proliferation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707649

10 September 2017

Proteasomal regulation of betac signaling reveals a novel mechanism for cytokine receptor heterotypic desensitization

1 reference

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10 September 2017

Beyond the RING: CBL proteins as multivalent adapters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707649

10 September 2017

RING finger mutations that abolish c-Cbl-directed polyubiquitination and downregulation of the EGF receptor are insufficient for cell transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707649

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Molecular mechanism for the Shp-2 tyrosine phosphatase function in promoting growth factor stimulation of Erk activity

1 reference

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10 September 2017

Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707649

10 September 2017

The Cbl proto-oncogene product negatively regulates the Src-family tyrosine kinase Fyn by enhancing its degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707649

10 September 2017

The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707649

10 September 2017

A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707649

10 September 2017

Jak2 is essential for signaling through a variety of cytokine receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707649

10 September 2017

A double-edged kinase Lyn: a positive and negative regulator for antigen receptor-mediated signals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707649

10 September 2017

Fyn, Yes, and Syk phosphorylation sites in c-Cbl map to the same tyrosine residues that become phosphorylated in activated T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707649

10 September 2017

Proto-oncoprotein Vav interacts with c-Cbl in activated thymocytes and peripheral T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707649

10 September 2017

Yeast two-hybrid in vivo association of the Src kinase Lyn with the proto-oncogene product Cbl but not with the p85 subunit of PI 3-kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707649

10 September 2017

Erythropoietin and interleukin-3 activate tyrosine phosphorylation of CBL and association with CRK adaptor proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707649

10 September 2017

Phosphorylation of Cbl following stimulation with interleukin-3 and its association with Grb2, Fyn, and phosphatidylinositol 3-kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707649

10 September 2017

Critical role of Lyn kinase in inhibition of neutrophil apoptosis by granulocyte-macrophage colony-stimulating factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707649

10 September 2017

Interaction of the c-cbl proto-oncogene product with the Tyk-2 protein tyrosine kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707649

10 September 2017

Tyrosine-phosphorylated Cbl binds to Crk after T cell activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707649

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The two major sites of cbl tyrosine phosphorylation in abl-transformed cells select the crkL SH2 domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707649

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Physical and functional association of the cbl protooncogen product with an src-family protein tyrosine kinase, p53/56lyn, in the B cell antigen receptor-mediated signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707649

10 September 2017

Stimulation through the T cell receptor induces Cbl association with Crk proteins and the guanine nucleotide exchange protein C3G

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707649

10 September 2017

https://api.crossref.org/works/10.1074%2FJBC.M113.475087

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JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707649

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The SH3 domain-binding T cell tyrosyl phosphoprotein p120. Demonstration of its identity with the c-cbl protooncogene product and in vivo complexes with Fyn, Grb2, and phosphatidylinositol 3-kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707649

10 September 2017

Association between Lyn protein tyrosine kinase (p53/56lyn) and the beta subunit of the granulocyte-macrophage colony-stimulating factor (GM-CSF) receptors in a GM-CSF-dependent human megakaryocytic leukemia cell line (M-07e)

1 reference

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10 September 2017

The proto-oncogene product c-Cbl becomes tyrosine phosphorylated by stimulation with GM-CSF or Epo and constitutively binds to the SH3 domain of Grb2/Ash in human hematopoietic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707649

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Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor

1 reference

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1 reference

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1 reference

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1 reference

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10 September 2017

Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707649

10 September 2017

Definition of the role of tyrosine residues of the common beta subunit regulating multiple signaling pathways of granulocyte-macrophage colony-stimulating factor receptor

1 reference

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CBL exon 8/9 mutants activate the FLT3 pathway and cluster in core binding factor/11q deletion acute myeloid leukemia/myelodysplastic syndrome subtypes.

1 reference

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14 September 2017

JAK kinases control IL-5 receptor ubiquitination, degradation, and internalization.

1 reference

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Involvement of Shc and Cbl-PI 3-kinase in Lyn-dependent proliferative signaling pathways for G-CSF.

1 reference

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25 September 2017

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1 reference

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25 September 2017

Roles of JAK kinases in human GM-CSF receptor signal transduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707649

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1 reference

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15 June 2018

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1 reference

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15 June 2018

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15 June 2018

Myeloid leukemia development in c-Cbl RING finger mutant mice is dependent on FLT3 signaling.

1 reference

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Frequent CBL mutations associated with 11q acquired uniparental disomy in myeloproliferative neoplasms

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21 August 2018

250K single nucleotide polymorphism array karyotyping identifies acquired uniparental disomy and homozygous mutations, including novel missense substitutions of c-Cbl, in myeloid malignancies

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21 August 2018

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1 reference

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21 August 2018

Mutations of the NF1 gene in children with juvenile myelomonocytic leukemia without clinical evidence of neurofibromatosis, type 1.

1 reference

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21 August 2018

Homozygous inactivation of the NF1 gene in bone marrow cells from children with neurofibromatosis type 1 and malignant myeloid disorders

1 reference

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21 August 2018

Requirement of Lyn and Syk tyrosine kinases for the prevention of apoptosis by cytokines in human eosinophils

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21 August 2018

Flt3-dependent transformation by inactivating c-Cbl mutations in AML

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https://api.crossref.org/works/10.1074%2FJBC.M113.475087

21 January 2018

Agonist-specific tyrosine phosphorylation of Cbl in human neutrophils

1 reference

https://pubmed.ncbi.nlm.nih.gov/23696637

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RAS mutations and clonality analysis in children with juvenile myelomonocytic leukemia (JMML)

1 reference

https://pubmed.ncbi.nlm.nih.gov/23696637

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Convergence of signaling by interleukin-3, granulocyte-macrophage colony-stimulating factor, and mast cell growth factor on JAK2 tyrosine kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/23696637

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations of the N-ras gene in juvenile chronic myelogenous leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/23696637

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective hypersensitivity to granulocyte-macrophage colony-stimulating factor by juvenile chronic myeloid leukemia hematopoietic progenitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/23696637

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M113.475087

1 reference

Europe PubMed Central

PMC publication ID

9 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

9 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

9 September 2017

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