(Q39242623)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23163584%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

title

Ligand binding induces a conformational change in epidermal growth factor receptor dimers (English)

1 reference

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18 February 2020

1 reference

7

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18 February 2020

Suzanne G Orchard

9

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18 February 2020

author name string

Francesca Walker

1

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18 February 2020

Julie Rothacker

2

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18 February 2020

Christine Henderson

3

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18 February 2020

Edouard C Nice

4

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18 February 2020

Bruno Catimel

5

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18 February 2020

Hui-Hua Zhang

6

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18 February 2020

Michael F Bailey

8

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18 February 2020

Timothy E Adams

10

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18 February 2020

Zhanqi Liu

11

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18 February 2020

Thomas P J Garrett

12

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18 February 2020

Andrew H A Clayton

13

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18 February 2020

Antony W Burgess

14

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18 February 2020

publication date

20 November 2012

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18 February 2020

published in

Growth Factors Journal

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18 February 2020

volume

30

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18 February 2020

issue

6

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18 February 2020

page(s)

394-409

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The membrane-proximal intracellular domain of the epidermal growth factor receptor underlies negative cooperativity in ligand binding

18 February 2020

cites work

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

A truncated soluble epidermal growth factor receptor-Fc fusion ligand trap displays anti-tumour activity in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

ErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Structural Basis for Negative Cooperativity in Growth Factor Binding to an EGF Receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Asymmetric tyrosine kinase arrangements in activation or autophosphorylation of receptor tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Cytohesins are cytoplasmic ErbB receptor activators

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Ligand-independent oncogenic signaling by the epidermal growth factor receptor: v-ErbB as a paradigm

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

The extracellular region of ErbB4 adopts a tethered conformation in the absence of ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Humanization of an anti-p185HER2 antibody for human cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Real-time and label-free detection of cellular response to signaling mediated by distinct subclasses of epidermal growth factor receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Spatial control of EGF receptor activation by reversible dimerization on living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Ligand-induced dimer-tetramer transition during the activation of the cell surface epidermal growth factor receptor-A multidimensional microscopy analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Activation of the Ras/mitogen-activated protein kinase pathway by kinase-defective epidermal growth factor receptors results in cell survival but not proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Predominance of activated EGFR higher-order oligomers on the cell surface.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Epidermal growth factor receptor dimerization and activation require ligand-induced conformational changes in the dimer interface

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Ligand-induced structural transitions in ErbB receptor extracellular domains

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

High-level and high-throughput recombinant protein production by transient transfection of suspension-growing human 293-EBNA1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Identification of a determinant of epidermal growth factor receptor ligand-binding specificity using a truncated, high-affinity form of the ectodomain.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Active and inactive conformations of the epidermal growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Structure-based view of epidermal growth factor receptor regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Oligomerization of epidermal growth factor receptors on A431 cells studied by time-resolved fluorescence imaging microscopy. A stereochemical model for tyrosine kinase receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor AG1478 increases the formation of inactive untethered EGFR dimers. Implications for combination therapy with monoclonal antibody 806.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Antibodies specifically targeting a locally misfolded region of tumor associated EGFR

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Ligand-induced EGF Receptor Oligomerization Is Kinase-dependent and Enhances Internalization

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Spatio-temporal modeling of signaling protein recruitment to EGFR.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

EGF signalling amplification induced by dynamic clustering of EGFR.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Eph receptor function is modulated by heterooligomerization of A and B type Eph receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Novel monoclonal antibody specific for the de2-7 epidermal growth factor receptor (EGFR) that also recognizes the EGFR expressed in cells containing amplification of the EGFR gene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Identification of the epitope for the epidermal growth factor receptor-specific monoclonal antibody 806 reveals that it preferentially recognizes an untethered form of the receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Epidermal growth factor receptor: mechanisms of activation and signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

A monoclonal antibody recognizing human cancers with amplification/overexpression of the human epidermal growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Growth stimulation of A431 cells by epidermal growth factor: identification of high-affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

A structure-based model for ligand binding and dimerization of EGF receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Creation and biophysical characterization of a high-affinity, monomeric EGF receptor ectodomain using fluorescent proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Differential and synergistic effects of epidermal growth factor receptor antibodies on unliganded ErbB dimers and oligomers.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Conformational dynamics in a truncated epidermal growth factor receptor ectodomain.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Evidence for extended YFP-EGFR dimers in the absence of ligand on the surface of living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Structure and function of the epidermal growth factor (EGF/ErbB) family of receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Ligand-induced ErbB receptor dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Structural basis for inhibition of the epidermal growth factor receptor by cetuximab

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Quantitation of the effect of ErbB2 on epidermal growth factor receptor binding and dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

A single ligand is sufficient to activate EGFR dimers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Structural Evidence for Loose Linkage between Ligand Binding and Kinase Activation in the Epidermal Growth Factor Receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

The tumor-specific de2-7 epidermal growth factor receptor (EGFR) promotes cells survival and heterodimerizes with the wild-type EGFR.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Heterogeneity in EGF-binding affinities arises from negative cooperativity in an aggregating system

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

The intracellular juxtamembrane domain of the epidermal growth factor (EGF) receptor is responsible for the allosteric regulation of EGF binding

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Mechanics of EGF receptor/ErbB2 kinase activation revealed by luciferase fragment complementation imaging

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

The docking protein Gab1 is the primary mediator of EGF-stimulated activation of the PI-3K/Akt cell survival pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Activation of preformed EGF receptor dimers by ligand-induced rotation of the transmembrane domain

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

On the nature of low- and high-affinity EGF receptors on living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Negative co-operativity in the EGF receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Human epidermal growth factor receptor (HER-1:HER-3) Fc-mediated heterodimer has broad antiproliferative activity in vitro and in human tumor xenografts

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Ligand-induced, receptor-mediated dimerization and activation of EGF receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Matuzumab Binding to EGFR Prevents the Conformational Rearrangement Required for Dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Interaction of antibodies with ErbB receptor extracellular regions

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Molecular dynamics analysis of conserved hydrophobic and hydrophilic bond-interaction networks in ErbB family kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Characterization of the carbohydrate chains of the secreted form of the human epidermal growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

N-glycan of ErbB family plays a crucial role in dimer formation and tumor promotion.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Single-molecule analysis of epidermal growth factor signaling that leads to ultrasensitive calcium response

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Transmodulation of the epidermal-growth-factor receptor in permeabilized 3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Biochemical characterization of mutant EGF receptors expressed in the hemopoietic cell line BaF/3.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

CR1/CR2 interactions modulate the functions of the cell surface epidermal growth factor receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Effect of ErbB2 coexpression on the kinetic interactions of epidermal growth factor with its receptor in intact cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Epidermal growth factor induces rapid, reversible aggregation of the purified epidermal growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

Epidermal growth factor receptor: association of extracellular domain negatively regulates intracellular kinase activation in the absence of ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08977194.2012.739619

10.3109/08977194.2012.739619

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23163584%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

1 reference