(Q39257808)

10 September 2017

title

Geranylgeranyltransferase I promotes human glioma cell growth through Rac1 membrane association and activation (English)

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10 September 2017

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Xiuping Zhou

1

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10 September 2017

Jinming Qian

2

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10 September 2017

Lei Hua

3

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10 September 2017

Qiong Shi

4

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10 September 2017

Zhi Liu

5

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10 September 2017

Yinfu Xu

6

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10 September 2017

Ben Sang

7

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10 September 2017

Jianbing Mo

8

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10 September 2017

Rutong Yu

9

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10 September 2017

publication date

17 October 2012

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Journal of Molecular Neuroscience

10 September 2017

published in

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10 September 2017

volume

49

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10 September 2017

issue

1

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10 September 2017

page(s)

130-139

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Targeting protein prenylation for cancer therapy

10 September 2017

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Involvement of RhoA and RalB in geranylgeranyltransferase I inhibitor-mediated inhibition of proliferation and migration of human oral squamous cell carcinoma cells

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In vivo fluorescence resonance energy transfer imaging reveals differential activation of Rho-family GTPases in glioblastoma cell invasion

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Standard of care therapy for malignant glioma and its effect on tumor and stromal cells

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Blockade of protein geranylgeranylation inhibits Cdk2-dependent p27Kip1 phosphorylation on Thr187 and accumulates p27Kip1 in the nucleus: implications for breast cancer therapy.

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The role of geranylgeranylated proteins in human mesangial cell proliferation

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TrkBT1 induces liver metastasis of pancreatic cancer cells by sequestering Rho GDP dissociation inhibitor and promoting RhoA activation

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Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung cancer

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In vivo antitumor effect of a novel inhibitor of protein geranylgeranyltransferase-I

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Trafficking and signaling by fatty-acylated and prenylated proteins

21 January 2018

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A novel geranylgeranyl transferase inhibitor in combination with lovastatin inhibits proliferation and induces autophagy in STS-26T MPNST cells

21 January 2018

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Protein farnesyltransferase and geranylgeranyltransferase share a common alpha subunit

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Geranylgeranyltransferase I is essential for dendritic development of cerebellar Purkinje cells

21 January 2018

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A protein geranylgeranyltransferase from bovine brain: implications for protein prenylation specificity

21 January 2018

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Protein prenylation: molecular mechanisms and functional consequences

21 January 2018

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Activin B promotes epithelial wound healing in vivo through RhoA-JNK signaling pathway

21 January 2018

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Targeted suicide gene therapy for glioma using human embryonic stem cell-derived neural stem cells genetically modified by baculoviral vectors.

21 January 2018

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21 January 2018

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TrkB-mediated activation of geranylgeranyltransferase I promotes dendritic morphogenesis

21 January 2018

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FRK controls migration and invasion of human glioma cells by regulating JNK/c-Jun signaling

21 January 2018

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Inactivating GGTase-I reduces disease phenotypes in a mouse model of K-RAS-induced myeloproliferative disease

21 January 2018

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12 December 2020

Molecular detection of tumor-associated antigens shared by human cutaneous melanomas and gliomas

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12 December 2020

Participation of the small molecular weight GTP-binding protein Rac1 in cell-free activation and assembly of the respiratory burst oxidase. Inhibition by a carboxyl-terminal Rac peptide.

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12 December 2020

Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models

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12 December 2020

Signal transduction pathways regulating Rho-mediated stress fibre formation: requirement for a tyrosine kinase

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12 December 2020

Synergistic Effect of Geranylgeranyltransferase Inhibitor, GGTI, and Docetaxel on the Growth of Prostate Cancer Cells

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12 December 2020

Geranylgeranyltransferase I inhibitor GGTI-2154 induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice.

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12 December 2020

In vitro identification of a soluble protein:geranylgeranyl transferase from rat tissues.

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12 December 2020

Mammalian protein geranylgeranyltransferase. Subunit composition and metal requirements

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12 December 2020

Suppression of Rac activity induces apoptosis of human glioma cells but not normal human astrocytes.

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12 December 2020

Geranylgeranyl transferase 1 modulates autophagy and apoptosis in human airway smooth muscle

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12 December 2020

Substrate interactions of protein prenyltransferases

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12 December 2020

10.1007/S12031-012-9905-3

Identifiers

DOI

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10 September 2017

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