(Q39272912)

10 September 2017

5-Arylidenethioxothiazolidinones as inhibitors of tyrosyl-DNA phosphodiesterase I. (English)

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10 September 2017

Yuk Y Sham

9

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Yves Pommier

10

object named as

Yves Pommier

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10 September 2017

Venkata Ramana Sirivolu

1

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10 September 2017

Sanjeev Kumar V Vernekar

2

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10 September 2017

Christophe Marchand

3

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10 September 2017

Alena Naumova

4

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10 September 2017

Adel Chergui

5

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10 September 2017

Amelie Renaud

6

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10 September 2017

Andrew G Stephen

7

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10 September 2017

Feng Chen

8

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10 September 2017

Zhengqiang Wang

11

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10 September 2017

language of work or name

English

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publication date

8 October 2012

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Journal of Medicinal Chemistry

10 September 2017

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10 September 2017

55

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10 September 2017

20

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10 September 2017

8671-8684

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describes a project that uses

10 September 2017

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7479925/fullTextXML

inferred from PubMed Central ID database lookup

cites work

The role of TDP1 from budding yeast in the repair of DNA damage

1 reference

12 December 2020

Synthesis, antimicrobial and cytotoxic activities of some 5-arylidene-4-thioxo-thiazolidine-2-ones

1 reference

12 December 2020

Thiazolidinediones: antidiabetic drugs with cardiovascular effects

1 reference

12 December 2020

DNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial Inhibition

1 reference

12 December 2020

Repair of topoisomerase I-mediated DNA damage

1 reference

12 December 2020

TDP1 overexpression in human cells counteracts DNA damage mediated by topoisomerases I and II

1 reference

12 December 2020

Topoisomerase I-mediated DNA damage

1 reference

12 December 2020

Discovery of a series of phosphonic acid-containing thiazoles and orally bioavailable diamide prodrugs that lower glucose in diabetic animals through inhibition of fructose-1,6-bisphosphatase

1 reference

12 December 2020

Tyrosyl-DNA phosphodiesterase 1 targeting for modulation of camptothecin-based treatment.

1 reference

12 December 2020

Structure-activity requirements for the antiproliferative effect of troglitazone derivatives mediated by depletion of intracellular calcium

1 reference

12 December 2020

Synthesis and biological evaluation of the first dual tyrosyl-DNA phosphodiesterase I (Tdp1)-topoisomerase I (Top1) inhibitors

1 reference

12 December 2020

Topoisomerase I inhibitors: camptothecins and beyond

1 reference

12 December 2020

New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays

1 reference

12 December 2020

Thiazolidinediones: a new class of drugs for the therapy of ischemia-reperfusion injury.

1 reference

12 December 2020

Inhibitory effects of multi-substituted benzylidenethiazolidine-2,4-diones on LDL oxidation

1 reference

12 December 2020

Tyrosyl-DNA phosphodiesterase as a target for anticancer therapy

1 reference

12 December 2020

Cellular inhibition of protein tyrosine phosphatase 1B by uncharged thioxothiazolidinone derivatives

1 reference

12 December 2020

Hereditary ataxia SCAN1 cells are defective for the repair of transcription-dependent topoisomerase I cleavage complexes

1 reference

12 December 2020

New drugs for the treatment of diabetes mellitus: part I: Thiazolidinediones and their evolving cardiovascular implications

1 reference

12 December 2020

Rhodanine as a privileged scaffold in drug discovery

1 reference

12 December 2020

Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs DNA damage induced by topoisomerases I and II and base alkylation in vertebrate cells

1 reference

12 December 2020

The indenoisoquinoline noncamptothecin topoisomerase I inhibitors: update and perspectives

1 reference

12 December 2020

Thiazolidinediones: a new class of antidiabetic drugs

1 reference

12 December 2020

Thiazolidinediones and type 2 diabetes: new drugs for an old disease.

1 reference

12 December 2020

Crystal structure of a transition state mimic for Tdp1 assembled from vanadate, DNA, and a topoisomerase I-derived peptide

1 reference

12 December 2020

DNA topoisomerases: structure, function, and mechanism

1 reference

12 December 2020

Catalytic mechanism of the phospholipase D superfamily proceeds via a covalent phosphohistidine intermediate

1 reference

12 December 2020

A eukaryotic enzyme that can disjoin dead-end covalent complexes between DNA and type I topoisomerases

1 reference

12 December 2020

Inhibition of human tyrosyl-DNA phosphodiesterase by aminoglycoside antibiotics and ribosome inhibitors

1 reference

12 December 2020

A broad-spectrum antiviral targeting entry of enveloped viruses

1 reference

12 December 2020

Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1

1 reference

12 December 2020

Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay

1 reference

12 December 2020

The crystal structure of human tyrosyl-DNA phosphodiesterase, Tdp1

1 reference

12 December 2020

Rhodanine derivatives as novel inhibitors of PDE4.

1 reference

12 December 2020

4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesulfonate) (NSC 88915) and related novel steroid derivatives as tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors

1 reference

12 December 2020

SCAN1 mutant Tdp1 accumulates the enzyme--DNA intermediate and causes camptothecin hypersensitivity

1 reference

12 December 2020

A search for new anticonvulsant compounds among 3-aryl-5-benzylidene derivatives of 2-thiohydantoin

1 reference

12 December 2020

Analysis of human tyrosyl-DNA phosphodiesterase I catalytic residues

1 reference

12 December 2020

Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme

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12 December 2020

Synopsis of some recent tactical application of bioisosteres in drug design

1 reference

12 December 2020

Parallel solution-phase synthesis of 2-alkylthio-5-arylidene-3,5-dihydro-4H-imidazol-4-one by one-pot three-component domino reaction

1 reference

12 December 2020

Privileged Scaffolds or Promiscuous Binders: A Comparative Study on Rhodanines and Related Heterocycles in Medicinal Chemistry

1 reference

12 December 2020

Repair of and checkpoint response to topoisomerase I-mediated DNA damage

1 reference

12 December 2020

The PLD superfamily: insights into catalysis

1 reference

12 December 2020

Interfacial inhibitors: targeting macromolecular complexes

1 reference

12 December 2020

Very fast empirical prediction and rationalization of protein pKa values

1 reference

12 December 2020

The tyrosyl-DNA phosphodiesterase Tdp1 is a member of the phospholipase D superfamily

1 reference

12 December 2020

Identifiers

DOI

10.1021/JM3008773

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10 September 2017

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