(Q39281800)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22964853%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

title

Heat shock protein 90 inhibitor attenuates renal fibrosis through degradation of transforming growth factor-β type II receptor (English)

1 reference

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12 February 2020

1 reference

7

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12 February 2020

author name string

Hyunjin Noh

1

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12 February 2020

Hyun J Kim

2

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12 February 2020

Mi R Yu

3

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12 February 2020

Wan-Young Kim

4

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12 February 2020

Jin Kim

5

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12 February 2020

Jung H Ryu

6

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12 February 2020

Jin S Jeon

8

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12 February 2020

Dong C Han

9

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12 February 2020

Fuad Ziyadeh

10

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12 February 2020

publication date

10 September 2012

1 reference

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12 February 2020

published in

Laboratory Investigation

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12 February 2020

volume

92

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12 February 2020

issue

11

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12 February 2020

page(s)

1583-1596

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https://scigraph.springernature.com/pub.10.1038/labinvest.2012.127

12 February 2020

exact match

0 references

cites work

Renal fibrosis: novel insights into mechanisms and therapeutic targets.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.127

Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?

21 January 2018

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TGF-beta signaling in renal disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.127

Renal fibrosis: new insights into the pathogenesis and therapeutics

21 January 2018

1 reference

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Smad transcription factors

21 January 2018

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Specificity and versatility in tgf-beta signaling through Smads

21 January 2018

1 reference

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Smad-dependent and Smad-independent pathways in TGF-beta family signalling

21 January 2018

1 reference

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Protein kinase B/Akt activity is involved in renal TGF-beta1-driven epithelial-mesenchymal transition in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.127

Role of reactive oxygen species in TGF-beta1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells.

21 January 2018

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Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery

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https://api.crossref.org/works/10.1038%2FLABINVEST.2012.127

Heat shock protein 90 as a molecular target for cancer therapeutics

21 January 2018

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A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

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Discovery and development of Hsp90 inhibitors: a promising pathway for cancer therapy

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Critical regulation of TGFbeta signaling by Hsp90

21 January 2018

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Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

21 January 2018

1 reference

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Pharmacological prevention of Parkinson disease in Drosophila.

21 January 2018

1 reference

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Geldanamycin induces heat shock proteins in brain and protects against focal cerebral ischemia

21 January 2018

1 reference

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Suppressive effects of ansamycins on inducible nitric oxide synthase expression and the development of experimental autoimmune encephalomyelitis

21 January 2018

1 reference

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17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration

21 January 2018

1 reference

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TGF-beta signal transduction and mesangial cell fibrogenesis

21 January 2018

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Suramin inhibits renal fibrosis in chronic kidney disease.

21 January 2018

1 reference

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Imatinib mesylate blocks a non-Smad TGF-beta pathway and reduces renal fibrogenesis in vivo

21 January 2018

1 reference

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Inhibition of integrin-linked kinase attenuates renal interstitial fibrosis

21 January 2018

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Signaling mechanism of TGF-beta1 in prevention of renal inflammation: role of Smad7.

21 January 2018

1 reference

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Increased glomerular and tubular expression of transforming growth factor-beta1, its type II receptor, and activation of the Smad signaling pathway in the db/db mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.127

New regulatory mechanisms of TGF-beta receptor function

21 January 2018

1 reference

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The type I TGF-beta receptor is covalently modified and regulated by sumoylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.127

E3 ubiquitin ligases as regulators of membrane protein trafficking and degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.127

Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.127

Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.127

PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

21 January 2018

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Involvement of Hsp90 in signaling and stability of 3-phosphoinositide-dependent kinase-1.

21 January 2018

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Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition

21 January 2018

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Suppression of experimental glomerulonephritis by antiserum against transforming growth factor β1

21 January 2018

1 reference

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Evidence that fibroblasts derive from epithelium during tissue fibrosis

21 January 2018

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7 January 2021

Neutralization of TGF-beta by anti-TGF-beta antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ-induced diabetic mice

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.127

7 January 2021

Therapy with antisense TGF-beta1 oligodeoxynucleotides reduces kidney weight and matrix mRNAs in diabetic mice

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7 January 2021

Stimulation of TGF-beta type II receptor by high glucose in mouse mesangial cells and in diabetic kidney

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7 January 2021