(Q39290679)

English

Arylsulfonamide KCN1 inhibits in vivo glioma growth and interferes with HIF signaling by disrupting HIF-1α interaction with cofactors p300/CBP.

scientific article published on 24 August 2012

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Arylsulfonamide KCN1 inhibits in vivo glioma growth and interferes with HIF signaling by disrupting HIF-1α interaction with cofactors p300/CBP. (English)

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Erwin G. Van Meir

17

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

author name string

Shaoman Yin

1

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Stefan Kaluz

2

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Narra S Devi

3

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Adnan A Jabbar

4

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Rita G de Noronha

5

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Jiyoung Mun

6

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Zhaobin Zhang

7

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Purushotham R Boreddy

8

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Wei Wang

9

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Zhibo Wang

10

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Thomas Abbruscato

11

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Zhengjia Chen

12

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Jeffrey J Olson

13

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Ruiwen Zhang

14

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Mark M Goodman

15

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

K C Nicolaou

16

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

language of work or name

0 references

publication date

24 August 2012

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Clinical Cancer Research

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

18

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

24

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

6623-6633

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

KCN1, a novel synthetic sulfonamide anticancer agent: in vitro and in vivo anti-pancreatic cancer activities and preclinical pharmacology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

10 September 2017

Design and in vitro activities of N-alkyl-N-[(8-R-2,2-dimethyl-2H-chromen-6-yl)methyl]heteroarylsulfonamides, novel, small-molecule hypoxia inducible factor-1 pathway inhibitors and anticancer agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

10 September 2017

Structure-activity relationship of 2,2-dimethyl-2H-chromene based arylsulfonamide analogs of 3,4-dimethoxy-N-[(2,2-dimethyl-2H-chromen-6-yl)methyl]-N-phenylbenzenesulfonamide, a novel small molecule hypoxia inducible factor-1 (HIF-1) pathway [...]

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

10 September 2017

Design and synthesis of novel small-molecule inhibitors of the hypoxia inducible factor pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

10 September 2017

Sulfonamides as a new scaffold for hypoxia inducible factor pathway inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

10 September 2017

Aminoflavone, a ligand of the aryl hydrocarbon receptor, inhibits HIF-1alpha expression in an AhR-independent fashion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

10 September 2017

Radiosensitization and stromal imaging response correlates for the HIF-1 inhibitor PX-478 given with or without chemotherapy in pancreatic cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

10 September 2017

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

10 September 2017

Complex regulation of the transactivation function of hypoxia-inducible factor-1 alpha by direct interaction with two distinct domains of the CREB-binding protein/p300.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

10 September 2017

Lipophilic 2,5-disubstituted pyrroles from the marine sponge Mycale sp. inhibit mitochondrial respiration and HIF-1 activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

10 September 2017

Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

10 September 2017

Identification of a novel small molecule HIF-1alpha translation inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

10 September 2017

HIF-1 inhibitors for cancer therapy: from gene expression to drug discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

10 September 2017

Epidithiodiketopiperazines block the interaction between hypoxia-inducible factor-1alpha (HIF-1alpha) and p300 by a zinc ejection mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

10 September 2017

Role of hypoxia in the hallmarks of human cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

10 September 2017

Vasculostatin inhibits intracranial glioma growth and negatively regulates in vivo angiogenesis through a CD36-dependent mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

10 September 2017

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

10 September 2017

Does inhibition of degradation of hypoxia-inducible factor (HIF) alpha always lead to activation of HIF? Lessons learnt from the effect of proteasomal inhibition on HIF activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

10 September 2017

Targeted cancer gene therapy using a hypoxia inducible factor dependent oncolytic adenovirus armed with interleukin-4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

10 September 2017

Inhibitors of hypoxia-inducible factor-1 signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

10 September 2017

Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

10 September 2017

Integration of oxygen signaling at the consensus HRE.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

10 September 2017

Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

10 September 2017

Hypoxia inducible factor-1: a novel target for cancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

10 September 2017

Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

10 September 2017

Vasculostatin, a proteolytic fragment of brain angiogenesis inhibitor 1, is an antiangiogenic and antitumorigenic factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

10 September 2017

Identification of a novel small-molecule inhibitor of the hypoxia-inducible factor 1 pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

10 September 2017

Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

10 September 2017

p300/CBP and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

10 September 2017

Tumor-specific gene expression using the survivin promoter is further increased by hypoxia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

10 September 2017

Hypoxia-inducible factor and its biomedical relevance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

10 September 2017

Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

10 September 2017

Genetic and biologic progression in astrocytomas and their relation to angiogenic dysregulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

10 September 2017

Cremophor EL: the drawbacks and advantages of vehicle selection for drug formulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

10 September 2017

HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

10 September 2017

WAF1, a potential mediator of p53 tumor suppression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

10 September 2017

Binding Model for the Interaction of Anticancer Arylsulfonamides with the p300 Transcription Cofactor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

14 September 2017

Engineering human tumor-specific cytotoxic T cells to function in a hypoxic environment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

14 September 2017

Antitumor effect of 2-methoxyestradiol in a rat orthotopic brain tumor model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

14 September 2017

Evaluating hypoxia-inducible factor-1alpha as a cancer therapeutic target via inducible RNA interference in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

14 September 2017

Necrogenesis and Fas/APO-1 (CD95) expression in primary (de novo) and secondary glioblastomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

25 September 2017

The hemodynamic effects of Cremophor-EL.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

17 June 2018

Cancer therapy with a replicating oncolytic adenovirus targeting the hypoxic microenvironment of tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

21 August 2018

A novel hypoxia-inducible factor (HIF) activated oncolytic adenovirus for cancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

21 August 2018

Expression of the hypoxia marker carbonic anhydrase IX is critically dependent on SP1 activity. Identification of a novel type of hypoxia-responsive enhancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

21 August 2018

Generation of bidirectional hypoxia/HIF-responsive expression vectors to target gene expression to hypoxic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

21 August 2018

Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

21 August 2018

"Turcot's syndrome": phenotype of brain tumors, survival and mode of inheritance.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518680

21 August 2018

Identifiers

10.1158/1078-0432.CCR-12-0861

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q39290679&oldid=1452322942"