(Q39309731)

English

Synergistic influence of phosphorylation and metal ions on tau oligomer formation and coaggregation with α-synuclein at the single molecule level

scientific article

In more languages

default values for all languages

No label defined

No description defined

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Synergistic influence of phosphorylation and metal ions on tau oligomer formation and coaggregation with α-synuclein at the single molecule level (English)

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

phosphorylation

0 references

1 reference

based on heuristic

inferred from title

6

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Georg S Nuebling

1 reference

ORCID Public Data File 2021

author name string

Georg Nübling

1

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Benedikt Bader

2

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Johannes Levin

3

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Jenna Hildebrandt

4

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Hans Kretzschmar

5

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

publication date

23 July 2012

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Molecular Neurodegeneration

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

7

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

35

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

E46K human alpha-synuclein transgenic mice develop Lewy-like and tau pathology associated with age-dependent, detrimental motor impairment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

11 September 2017

Induction of intracellular tau aggregation is promoted by α-synuclein seeds and provides novel insights into the hyperphosphorylation of tau.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

11 September 2017

Aggregation of detergent-insoluble tau is involved in neuronal loss but not in synaptic loss

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

11 September 2017

Increased alpha-synuclein aggregation following limited cleavage by certain matrix metalloproteinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

11 September 2017

Human health risk assessment for aluminium, aluminium oxide, and aluminium hydroxide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

11 September 2017

Site-specific effects of tau phosphorylation on its microtubule assembly activity and self-aggregation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

11 September 2017

Granular tau oligomers as intermediates of tau filaments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

11 September 2017

Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

11 September 2017

Tau suppression in a neurodegenerative mouse model improves memory function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

11 September 2017

Measurement of phosphorylated tau epitopes in the differential diagnosis of Alzheimer disease: a comparative cerebrospinal fluid study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

11 September 2017

Colocalization of Tau and Alpha-Synuclein Epitopes in Lewy Bodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

11 September 2017

Ultrasensitive detection of pathological prion protein aggregates by dual-color scanning for intensely fluorescent targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

11 September 2017

Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and P38, and glycogen synthase kinase-3beta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

11 September 2017

C-terminal alpha-synuclein immunoreactivity in structures other than Lewy bodies in neurodegenerative disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

11 September 2017

Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

11 September 2017

Iron accumulation in Alzheimer disease is a source of redox-generated free radicals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

11 September 2017

Selective accumulation of aluminum and iron in the neurofibrillary tangles of Alzheimer's disease: a laser microprobe (LAMMA) study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

11 September 2017

Preparation and characterization of neurotoxic tau oligomers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

14 September 2017

Converse modulation of toxic alpha-synuclein oligomers in living cells by N'-benzylidene-benzohydrazide derivates and ferric iron

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

14 September 2017

Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

25 September 2017

Pseudohyperphosphorylation causing AD-like changes in tau has significant effects on its polymerization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

17 June 2018

GSK-3beta phosphorylation of functionally distinct tau isoforms has differential, but mild effects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

17 June 2018

Brain aluminum, magnesium and phosphorus contents of control and Alzheimer-diseased patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

17 June 2018

Ca2+ and Mg2+ selectively induce aggregates of PHF-tau but not normal human tau.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

17 June 2018

Tau phosphorylation in transgenic mice expressing glycogen synthase kinase-3beta transgenes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

17 June 2018

Copper, iron, and zinc imbalances in severely degenerated brain regions in Alzheimer's disease: possible relation to oxidative stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

17 June 2018

Glycogen synthase kinase 3 alteration in Alzheimer disease is related to neurofibrillary tangle formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

17 June 2018

Preferential labeling of Alzheimer neurofibrillary tangles with antisera for tau protein kinase (TPK) I/glycogen synthase kinase-3 beta and cyclin-dependent kinase 5, a component of TPK II.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

17 June 2018

Brain levels of microtubule-associated protein tau are elevated in Alzheimer's disease: a radioimmuno-slot-blot assay for nanograms of the protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

17 June 2018

Phosphate analysis and dephosphorylation of modified tau associated with paired helical filaments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

17 June 2018

Brain aluminum in Alzheimer's disease using an improved GFAAS method

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

17 June 2018

Generation of ferric iron links oxidative stress to α-synuclein oligomer formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

21 August 2018

Single particle characterization of iron-induced pore-forming alpha-synuclein oligomers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

21 August 2018

Tau phosphorylation by GSK-3beta promotes tangle-like filament morphology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

21 August 2018

Increased level of active GSK-3beta in Alzheimer's disease and accumulation in argyrophilic grains and in neurones at different stages of neurofibrillary degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

21 August 2018

Chronic lithium administration to FTDP-17 tau and GSK-3beta overexpressing mice prevents tau hyperphosphorylation and neurofibrillary tangle formation, but pre-formed neurofibrillary tangles do not revert.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

21 August 2018

CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

21 August 2018

Aluminum in hippocampal neurons from humans with Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

21 August 2018

Activation of glycogen synthase kinase-3 induces Alzheimer-like tau hyperphosphorylation in rat hippocampus slices in culture

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

21 August 2018

Proteolysis of non-phosphorylated and phosphorylated tau by thrombin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

21 August 2018

Fibrillization of alpha-synuclein and tau in familial Parkinson's disease caused by the A53T alpha-synuclein mutation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

21 August 2018

Pseudophosphorylation of tau protein alters its ability for self-aggregation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

21 August 2018

EXPERIMENTAL PRODUCTION OF NEUROFIBRILLARY DEGENERATION. I. LIGHT MICROSCOPIC OBSERVATIONS

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

21 August 2018

Initiation and Synergistic Fibrillization of Tau and Alpha-Synuclein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

21 August 2018

Iron (III) induces aggregation of hyperphosphorylated tau and its reduction to iron (II) reverses the aggregation: implications in the formation of neurofibrillary tangles of Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

21 August 2018

Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

21 August 2018

Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

21 August 2018

Glycogen synthase kinase-3beta phosphorylates protein tau and rescues the axonopathy in the central nervous system of human four-repeat tau transgenic mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

21 August 2018

Distribution of active glycogen synthase kinase 3beta (GSK-3beta) in brains staged for Alzheimer disease neurofibrillary changes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

21 August 2018

Phosphorylation sensitizes microtubule-associated protein tau to Al(3+)-induced aggregation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

21 August 2018

Distribution, levels, and activity of glycogen synthase kinase-3 in the Alzheimer disease brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

21 August 2018

Assembly of Alzheimer-like filaments from full-length tau protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

21 August 2018

Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

21 August 2018

Monoclonal antibody AT8 recognises tau protein phosphorylated at both serine 202 and threonine 205.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

21 August 2018

Aluminum modifies the properties of Alzheimer's disease PHF tau proteins in vivo and in vitro.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472288

21 August 2018

Polymerization of tau into filaments in the presence of heparin: the minimal sequence required for tau-tau interaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/22824345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Single particle analysis of tau oligomer formation induced by metal ions and organic solvents

1 reference

https://pubmed.ncbi.nlm.nih.gov/22824345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Non-haem iron histochemistry of the normal and Alzheimer's disease hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/22824345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Single particle detection and characterization of synuclein co-aggregation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22824345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification and isolation of a hyperphosphorylated, conformationally changed intermediate of human protein tau expressed in yeast

1 reference

https://pubmed.ncbi.nlm.nih.gov/22824345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AD2, a phosphorylation-dependent monoclonal antibody directed against tau proteins found in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22824345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/1750-1326-7-35

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Dimensions Publication ID

0 references

release_hypmyhjysfbypeu4xv6krwhivm

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q39309731&oldid=2202768690"