(Q39314776)

10 September 2017

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title

Interleukin 17 is a chief orchestrator of immunity (English)

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10 September 2017

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1

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10 September 2017

language of work or name

English

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publication date

1 May 2017

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10 September 2017

number of pages

10

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inferred from page(s)

published in

Nature Immunology

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10 September 2017

volume

18

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10 September 2017

issue

6

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10 September 2017

page(s)

612-621

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https://scigraph.springernature.com/pub.10.1038/ni.3742

10 September 2017

exact match

0 references

cites work

IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding

1 reference

TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells

21 January 2018

1 reference

T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines

21 January 2018

1 reference

Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor

21 January 2018

1 reference

Identification of an interleukin 17F/17A heterodimer in activated human CD4+ T cells

21 January 2018

1 reference

Life before seventeen: cloning of the IL-17 receptor

21 January 2018

1 reference

Cutting edge: interleukin 17 signals through a heteromeric receptor complex

21 January 2018

1 reference

Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

21 January 2018

1 reference

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

21 January 2018

1 reference

21 January 2018

1 reference

Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling

21 January 2018

1 reference

Th17 T cells: linking innate and adaptive immunity

21 January 2018

1 reference

The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing

21 January 2018

1 reference

Fate mapping of IL-17-producing T cells in inflammatory responses

21 January 2018

1 reference

Regulation of epithelial immunity by IL-17 family cytokines

21 January 2018

1 reference

Dual nature of the adaptive immune system in lampreys

21 January 2018

1 reference

Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells

21 January 2018

1 reference

Characterization of Lamprey IL-17 Family Members and Their Receptors.

21 January 2018

1 reference

The evolution of vertebrate antigen receptors: a phylogenetic approach

21 January 2018

1 reference

IL-17A-producing resident memory γδ T cells orchestrate the innate immune response to secondary oral Listeria monocytogenes infection

21 January 2018

1 reference

Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses.

21 January 2018

1 reference

Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses

21 January 2018

1 reference

Cytokine-mediated regulation of antimicrobial proteins

21 January 2018

1 reference

Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction.

21 January 2018

1 reference

The front line of enteric host defense against unwelcome intrusion of harmful microorganisms: mucins, antimicrobial peptides, and microbiota

21 January 2018

1 reference

Interleukin-17 receptor deficiency results in impaired synovial expression of interleukin-1 and matrix metalloproteinases 3, 9, and 13 and prevents cartilage destruction during chronic reactivated streptococcal cell wall-induced arthritis.

21 January 2018

1 reference

Interleukin-17-induced gene expression in articular chondrocytes is associated with activation of mitogen-activated protein kinases and NF-kappaB.

21 January 2018

1 reference

Prolonged, granulocyte-macrophage colony-stimulating factor-dependent, neutrophil survival following rheumatoid synovial fibroblast activation by IL-17 and TNFalpha

21 January 2018

1 reference

IL-17 selectively down-regulates TNF-alpha-induced RANTES gene expression in human colonic subepithelial myofibroblasts

21 January 2018

1 reference

Structure and signalling in the IL-17 receptor family

21 January 2018

1 reference

Genome-wide comparison between IL-17A- and IL-17F-induced effects in human rheumatoid arthritis synoviocytes.

21 January 2018

1 reference

Functional Cooperation between Interleukin-17 and Tumor Necrosis Factor-α Is Mediated by CCAAT/Enhancer-binding Protein Family Members

21 January 2018

1 reference

Identification of common transcriptional regulatory elements in interleukin-17 target genes

21 January 2018

1 reference

Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells

21 January 2018

1 reference

The aryl hydrocarbon receptor in innate T cell immunity

21 January 2018

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Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides

21 January 2018

1 reference

IL-17a and IL-22 Induce Expression of Antimicrobials in Gastrointestinal Epithelial Cells and May Contribute to Epithelial Cell Defense against Helicobacter pylori

21 January 2018

1 reference

Dual Role of IL-22 in Allergic Airway Inflammation and its Cross-talk with IL-17A

21 January 2018

1 reference

Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A

21 January 2018

1 reference

Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose

21 January 2018

1 reference

Transcription factor c-Maf mediates the TGF-β-dependent suppression of IL-22 production in T(H)17 cells.

21 January 2018

1 reference

Regulation and functions of the IL-10 family of cytokines in inflammation and disease

21 January 2018

1 reference

A novel role for IL-22R1 as a driver of inflammation

21 January 2018

1 reference

Proinflammatory role of the Th17 cytokine interleukin-22 in collagen-induced arthritis in C57BL/6 mice

21 January 2018

1 reference

IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-gamma are not.

21 January 2018

1 reference

IL-22 is required for imiquimod-induced psoriasiform skin inflammation in mice

21 January 2018

1 reference

Inhibition of keratinocyte differentiation by the synergistic effect of IL-17A, IL-22, IL-1α, TNFα and oncostatin M.

21 January 2018

1 reference

Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses

21 January 2018

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Integrative responses to IL-17 and TNF-α in human keratinocytes account for key inflammatory pathogenic circuits in psoriasis

21 January 2018

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IL-17 and TNF synergistically modulate cytokine expression while suppressing melanogenesis: potential relevance to psoriasis

21 January 2018

1 reference

Synergistic Induction of Macrophage Inflammatory Protein-3α;/CCL20 Production by Interleukin-17A and Tumor Necrosis Factor-α; in Nasal Polyp Fibroblasts

21 January 2018

1 reference

IL-17A and IL-17F stimulate chemokines via MAPK pathways (ERK1/2 and p38 but not JNK) in mouse cultured mesangial cells: synergy with TNF-alpha and IL-1beta

21 January 2018

1 reference

IL-17 and TNF-α sustain neutrophil recruitment during inflammation through synergistic effects on endothelial activation

21 January 2018

1 reference

T helper 17 cell heterogeneity and pathogenicity in autoimmune disease

21 January 2018

1 reference

Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells

21 January 2018

1 reference

IL-17A synergizes with IFN-γ to upregulate iNOS and NO production and inhibit chlamydial growth

21 January 2018

1 reference

Collaborative Interferon-γ and Interleukin-17 Signaling Protects the Oral Mucosa from Staphylococcus aureus

21 January 2018

1 reference

Interleukin 17 receptor signaling is deleterious during Toxoplasma gondii infection in susceptible BL6 mice.

21 January 2018

1 reference

Neutralization of IL-17 ameliorates uveitis but damages photoreceptors in a murine model of spondyloarthritis

21 January 2018

1 reference

IL-22 mediates host defense against an intestinal intracellular parasite in the absence of IFN-γ at the cost of Th17-driven immunopathology

21 January 2018

1 reference

Plasticity of Th17 cells in Peyer's patches is responsible for the induction of T cell-dependent IgA responses

21 January 2018

1 reference

Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice

21 January 2018

1 reference

The Role of Neutrophils in the Induction of Specific Th1 and Th17 during Vaccination against Tuberculosis

21 January 2018

1 reference

The roles of IL-17A in inflammatory immune responses and host defense against pathogens

21 January 2018

1 reference

Effects of early IL-17A neutralization on disease induction in a primate model of experimental autoimmune encephalomyelitis

21 January 2018

1 reference

Effects of interleukin (IL)-17A and IL-17F in human rheumatoid arthritis synoviocytes

21 January 2018

1 reference

Regulation of inflammatory responses by IL-17F

21 January 2018

1 reference

Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals

21 January 2018

1 reference

Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense

21 January 2018

1 reference

IL-17 receptor signaling influences virus-induced corneal inflammation

21 January 2018

1 reference

Virus-specific interleukin-17-producing CD4+ T cells are detectable in early human immunodeficiency virus type 1 infection

21 January 2018

1 reference

Local IL-17A potentiates early neutrophil recruitment to the respiratory tract during severe RSV infection

21 January 2018

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Critical role of IL-17RA in immunopathology of influenza infection

21 January 2018

1 reference

Th17 cells are the dominant T cell subtype primed by Shigella flexneri mediating protective immunity

21 January 2018

1 reference

TGFbeta1, a "Jack of all trades": the link with pro-inflammatory IL-17-producing T cells

21 January 2018

1 reference

The involvement of IL-17A in the murine response to sub-lethal inhalational infection with Francisella tularensis

21 January 2018

1 reference

Differentiation and function of Th17 T cells

21 January 2018

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Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis

21 January 2018

1 reference

Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice

21 January 2018

1 reference

Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity

21 January 2018

1 reference

Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I

21 January 2018

1 reference

Interleukin-23 (IL-23)-IL-17 cytokine axis in murine Pneumocystis carinii infection

21 January 2018

1 reference

Oral-resident natural Th17 cells and γδ T cells control opportunistic Candida albicans infections

21 January 2018

1 reference

Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3

21 January 2018

1 reference

Novel signal transducer and activator of transcription 3 (STAT3) mutations, reduced T(H)17 cell numbers, and variably defective STAT3 phosphorylation in hyper-IgE syndrome

21 January 2018

1 reference

IL-6 trans-signalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF-alpha and IL-17.

21 January 2018

1 reference

Prominent bone loss mediated by RANKL and IL-17 produced by CD4+ T cells in TallyHo/JngJ mice

21 January 2018

1 reference

Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction

21 January 2018

1 reference

On-going Mechanical Damage from Mastication Drives Homeostatic Th17 Cell Responses at the Oral Barrier

21 January 2018

1 reference

The interleukin-17 receptor plays a gender-dependent role in host protection against Porphyromonas gingivalis-induced periodontal bone loss

21 January 2018

1 reference

An essential role for IL-17 in preventing pathogen-initiated bone destruction: recruitment of neutrophils to inflamed bone requires IL-17 receptor-dependent signals

21 January 2018

1 reference

Regulation of RANKL and OPG gene expression in human gingival fibroblasts and periodontal ligament cells by Porphyromonas gingivalis: a putative role of the Arg-gingipains

21 January 2018

1 reference

Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense

21 January 2018

1 reference

IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia

21 January 2018

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Cellular Plasticity of CD4+ T Cells in the Intestine

21 January 2018

1 reference

Th22 cells are an important source of IL-22 for host protection against enteropathogenic bacteria

21 January 2018

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Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

21 January 2018

1 reference

IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways

21 January 2018

1 reference

Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis

21 January 2018

1 reference

IL-17A produced by gammadelta T cells plays a critical role in innate immunity against listeria monocytogenes infection in the liver

21 January 2018

1 reference

Interleukin-17/interleukin-17 receptor-mediated signaling is important for generation of an optimal polymorphonuclear response against Toxoplasma gondii infection

21 January 2018

1 reference

Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages

21 January 2018

1 reference

IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17 response during tuberculosis but is dispensable for protection and antigen-specific IFN-gamma responses if IL-12p70 is available

21 January 2018

1 reference

IL-17 production is dominated by gammadelta T cells rather than CD4 T cells during Mycobacterium tuberculosis infection.

21 January 2018

1 reference

T cell-intrinsic role of IL-6 signaling in primary and memory responses

21 January 2018

1 reference

Signals mediated by transforming growth factor-beta initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease.

21 January 2018

1 reference

Tbet or Continued RORγt Expression Is Not Required for Th17-Associated Immunopathology.

21 January 2018

1 reference

IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis

21 January 2018

1 reference

Overexpression of IL-17 in the knee joint of collagen type II immunized mice promotes collagen arthritis and aggravates joint destruction

21 January 2018

1 reference

Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion

21 January 2018

1 reference

21 January 2018

1 reference

A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes

21 January 2018

1 reference

IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis

21 January 2018

1 reference

S100 protein subcellular localization during epidermal differentiation and psoriasis

21 January 2018

1 reference

Psoriasis is associated with increased beta-defensin genomic copy number

21 January 2018

1 reference

Pathogenesis and clinical features of psoriasis

21 January 2018

1 reference

Increased expression of interleukin 17 in inflammatory bowel disease

21 January 2018

1 reference

Contrasting roles of IL-12p40 and IL-12p35 in the development of hapten-induced colitis

21 January 2018

1 reference

Th17 cells give rise to Th1 cells that are required for the pathogenesis of colitis

21 January 2018

1 reference

IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6

21 January 2018

1 reference

Genetics and pathogenesis of inflammatory bowel disease

21 January 2018

1 reference

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

21 January 2018

1 reference

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

21 January 2018

1 reference

Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial

21 January 2018

1 reference

Efficacy and safety of secukinumab in patients with rheumatoid arthritis: a phase II, dose-finding, double-blind, randomised, placebo controlled study

21 January 2018

1 reference

Efficacy and safety of secukinumab, a fully human anti-interleukin-17A monoclonal antibody, in patients with moderate-to-severe psoriatic arthritis: a 24-week, randomised, double-blind, placebo-controlled, phase II proof-of-concept trial

21 January 2018

1 reference

Secukinumab, an Interleukin-17A Inhibitor, in Ankylosing Spondylitis

21 January 2018

1 reference

Ixekizumab for the Treatment of Psoriasis: A Review of Phase III Trials

21 January 2018

1 reference

Ixekizumab, an interleukin-17A specific monoclonal antibody, for the treatment of biologic-naive patients with active psoriatic arthritis: results from the 24-week randomised, double-blind, placebo-controlled and active (adalimumab)-controlled perio

21 January 2018

1 reference

Therapeutic Targeting of IL-17 and IL-23 Cytokines in Immune-Mediated Diseases

21 January 2018

1 reference

A protective function for interleukin 17A in T cell-mediated intestinal inflammation

21 January 2018

1 reference

Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology.

21 January 2018

1 reference

IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease

21 January 2018

1 reference

IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4(+) Th17 cells

21 January 2018

1 reference

The transcription factor T-bet regulates intestinal inflammation mediated by interleukin-7 receptor+ innate lymphoid cells.

21 January 2018

1 reference

IL-23R+ innate lymphoid cells induce colitis via interleukin-22-dependent mechanism

21 January 2018

1 reference

Transient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing TH17 cells and preserving group 3 innate lymphoid cells

21 January 2018

1 reference

Cross-talk between T cells and innate immune cells is crucial for IFN-gamma-dependent tumor rejection

21 January 2018

1 reference

Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments

21 January 2018

1 reference

Endogenous IL-17 contributes to reduced tumor growth and metastasis

21 January 2018

1 reference

The biology of cancer: metabolic reprogramming fuels cell growth and proliferation

21 January 2018

1 reference

Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1

21 January 2018

1 reference

Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells

21 January 2018

1 reference

HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells

21 January 2018

1 reference

ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis

21 January 2018

1 reference

IL-17 can promote tumor growth through an IL-6-Stat3 signaling pathway

21 January 2018

1 reference

IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis

21 January 2018

1 reference

IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge

21 January 2018

1 reference

IL-17+ γδ T cells as kick-starters of inflammation.

21 January 2018

1 reference

7 January 2021

IL-17 Signaling: The Yin and the Yang.

1 reference

7 January 2021

Interleukin 22 serum levels are associated with radiographic progression in rheumatoid arthritis

1 reference

7 January 2021

A role for T cell-derived interleukin 22 in psoriatic skin inflammation

1 reference

7 January 2021

Interleukin-22 promotes osteoclastogenesis in rheumatoid arthritis through induction of RANKL in human synovial fibroblasts

1 reference

7 January 2021

Skin Inflammation Induced by the Synergistic Action of IL-17A, IL-22, Oncostatin M, IL-1 , and TNF- Recapitulates Some Features of Psoriasis

1 reference

7 January 2021

IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis

1 reference

7 January 2021

Development of an anti-IL-17A auto-vaccine that prevents experimental auto-immune encephalomyelitis

1 reference

7 January 2021

Understanding the IL-23-IL-17 immune pathway

1 reference

7 January 2021

IL-17 regulates the expressions of RANKL and OPG in human periodontal ligament cells via TRAF6/TBK1-JNK/NF-κB pathways

1 reference

7 January 2021

Lymphoid neogenesis in rheumatoid synovitis

1 reference

7 January 2021

Inflammation and ectopic lymphoid structures in rheumatoid arthritis synovial tissues dissected by genomics technology: identification of the interleukin-7 signaling pathway in tissues with lymphoid neogenesis

1 reference

7 January 2021

Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice

1 reference

7 January 2021

IL-17 promotes bone erosion in murine collagen-induced arthritis through loss of the receptor activator of NF-kappa B ligand/osteoprotegerin balance

1 reference

7 January 2021

Critical role of IL-17 receptor signaling in acute TNBS-induced colitis

1 reference

7 January 2021

Cutting edge: IL-23 cross-regulates IL-12 production in T cell-dependent experimental colitis

1 reference

7 January 2021

Th17 and cancer: friends or foes?

1 reference

7 January 2021

CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28518156

12 December 2020

inferred from PubMed ID database lookup

IL-17: prototype member of an emerging cytokine family

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28518156

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/NI.3742

1 reference

Dimensions Publication ID

10 September 2017

1085435317

0 references

Fatcat ID

release_6jj6qkkdh5fplmiwotxlt3mc3i

0 references

1 reference