(Q39315073)

English

A novel PKB/Akt inhibitor, MK-2206, effectively inhibits insulin-stimulated glucose metabolism and protein synthesis in isolated rat skeletal muscle.

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22793019%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

A novel PKB/Akt inhibitor, MK-2206, effectively inhibits insulin-stimulated glucose metabolism and protein synthesis in isolated rat skeletal muscle (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22793019%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22793019%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22793019%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

author name string

Roxane Jacobs

3

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22793019%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Mark H Rider

4

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22793019%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

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1 October 2012

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22793019%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Biochemical Journal

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22793019%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

447

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22793019%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1

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7 February 2020

137-147

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22793019%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

AKT/PKB signaling: navigating downstream

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120772

21 January 2018

Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120772

21 January 2018

The deficiency of Akt1 is sufficient to suppress tumor development in Pten+/- mice

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120772

21 January 2018

Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120772

21 January 2018

Targeting the phosphoinositide 3-kinase pathway in cancer

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120772

21 January 2018

Insulin, but not contraction, activates Akt/PKB in isolated rat skeletal muscle

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120772

21 January 2018

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120772

21 January 2018

Conditional activation of akt in adult skeletal muscle induces rapid hypertrophy

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120772

21 January 2018

Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120772

21 January 2018

PDK1, one of the missing links in insulin signal transduction?

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120772

21 January 2018

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120772

21 January 2018

Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120772

21 January 2018

Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 trafficking

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120772

21 January 2018

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120772

21 January 2018

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120772

21 January 2018

Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120772

21 January 2018

Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120772

21 January 2018

Rapid activation of Akt2 is sufficient to stimulate GLUT4 translocation in 3T3-L1 adipocytes

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120772

21 January 2018

Evidence against protein kinase B as a mediator of contraction-induced glucose transport and GLUT4 translocation in rat skeletal muscle

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120772

21 January 2018

Contraction regulation of Akt in rat skeletal muscle

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120772

21 January 2018

The Akt/PKB family of protein kinases: a review of small molecule inhibitors and progress towards target validation: a 2009 update

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120772

21 January 2018

Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120772

21 January 2018

Characterization of a protein kinase B inhibitor in vitro and in insulin-treated liver cells

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120772

21 January 2018

First-in-man clinical trial of the oral pan-AKT inhibitor MK-2206 in patients with advanced solid tumors

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120772

21 January 2018

An allosteric Akt inhibitor effectively blocks Akt signaling and tumor growth with only transient effects on glucose and insulin levels in vivo

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120772

21 January 2018

Protein kinase B activity is required for the effects of insulin on lipid metabolism in adipocytes

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120772

21 January 2018

Akt inhibitors reduce glucose uptake independently of their effects on Akt.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120772

21 January 2018

Next-generation Akt inhibitors provide greater specificity: effects on glucose metabolism in adipocytes.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120772

21 January 2018

Additive effect of contraction and insulin on glucose uptake and glycogen synthase in muscle with different glycogen contents.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120772

21 January 2018

Heart 6-phosphofructo-2-kinase activation by insulin requires PKB (protein kinase B), but not SGK3 (serum- and glucocorticoid-induced protein kinase 3).

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120772

21 January 2018

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120772

21 January 2018

Contraction stimulates translocation of glucose transporter GLUT4 in skeletal muscle through a mechanism distinct from that of insulin

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120772

21 January 2018

Tyr(612) and Tyr(632) in human insulin receptor substrate-1 are important for full activation of insulin-stimulated phosphatidylinositol 3-kinase activity and translocation of GLUT4 in adipose cells

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120772

21 January 2018

Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120772

21 January 2018

Amplification and demultiplexing in insulin-regulated Akt protein kinase pathway in adipocytes.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120772

21 January 2018

AMPK: a key sensor of fuel and energy status in skeletal muscle

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120772

21 January 2018

Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120772

21 January 2018

Contraction activates glucose uptake and glycogen synthase normally in muscles from dexamethasone-treated rats.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120772

21 January 2018

Constitutive activation of protein kinase B alpha by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120772

21 January 2018

Dissecting multiple steps of GLUT4 trafficking and identifying the sites of insulin action.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120772

21 January 2018

Allosteric regulation of glycogen synthase controls glycogen synthesis in muscle

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120772

21 January 2018

Insulin promotes glycogen synthesis in the absence of GSK3 phosphorylation in skeletal muscle

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120772

21 January 2018

MK-2206, an allosteric Akt inhibitor, enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120772

21 January 2018

Dysregulation of glycogen synthase COOH- and NH2-terminal phosphorylation by insulin in obesity and type 2 diabetes mellitus

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120772

21 January 2018

Cellular mechanisms of insulin resistance

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120772

21 January 2018

Glycogen content and contraction regulate glycogen synthase phosphorylation and affinity for UDP-glucose in rat skeletal muscles.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120772

21 January 2018

Effects of contraction and insulin on protein synthesis, AMP-activated protein kinase and phosphorylation state of translation factors in rat skeletal muscle

1 reference

https://api.crossref.org/works/10.1042%2FBJ20120772

21 January 2018

Identifiers

10.1042/BJ20120772

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22793019%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

release_anpvdrf2graxdpbfrisrkzrylu

1 reference

https://api.fatcat.wiki/v0/release/anpvdrf2graxdpbfrisrkzrylu

24 November 2022

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22793019%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

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