(Q39325781)

11 September 2017

title

Hedgehog-GLI signaling drives self-renewal and tumorigenicity of human melanoma-initiating cells (English)

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11 September 2017

Roberta Santini

1

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11 September 2017

Maria C Vinci

2

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11 September 2017

Silvia Pandolfi

3

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11 September 2017

Junia Y Penachioni

4

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11 September 2017

Valentina Montagnani

5

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11 September 2017

Biagio Olivito

6

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11 September 2017

Riccardo Gattai

7

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11 September 2017

Nicola Pimpinelli

8

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11 September 2017

Gianni Gerlini

9

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11 September 2017

Lorenzo Borgognoni

10

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11 September 2017

Barbara Stecca

11

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11 September 2017

publication date

1 September 2012

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11 September 2017

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11 September 2017

volume

30

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11 September 2017

issue

9

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11 September 2017

page(s)

1808-1818

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Final version of 2009 AJCC melanoma staging and classification

11 September 2017

cites work

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COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

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Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

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Stem cells, cancer, and cancer stem cells

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A tumorigenic subpopulation with stem cell properties in melanomas

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Melanoma contains CD133 and ABCG2 positive cells with enhanced tumourigenic potential.

21 January 2018

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Identification of cells initiating human melanomas

21 January 2018

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MDR1 expression identifies human melanoma stem cells.

21 January 2018

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Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271

21 January 2018

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Human CD271-positive melanoma stem cells associated with metastasis establish tumor heterogeneity and long-term growth

21 January 2018

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Selection of tumorigenic melanoma cells using ALDH.

21 January 2018

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Efficient tumour formation by single human melanoma cells

21 January 2018

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Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized

21 January 2018

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Hedgehog signaling in development and cancer.

21 January 2018

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Context-dependent regulation of the GLI code in cancer by HEDGEHOG and non-HEDGEHOG signals

21 January 2018

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Sonic Hedgehog promotes the development of multipotent neural crest progenitors endowed with both mesenchymal and neural potentials

21 January 2018

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Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways.

21 January 2018

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Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo

21 January 2018

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Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches.

21 January 2018

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Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex.

21 January 2018

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In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog

21 January 2018

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Sustained Hedgehog signaling is required for basal cell carcinoma proliferation and survival: conditional skin tumorigenesis recapitulates the hair growth cycle

21 January 2018

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Nerve-derived sonic hedgehog defines a niche for hair follicle stem cells capable of becoming epidermal stem cells

21 January 2018

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GLI2-mediated melanoma invasion and metastasis

21 January 2018

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HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity

21 January 2018

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Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion

21 January 2018

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Sonic hedgehog pathway is essential for maintenance of cancer stem-like cells in human gastric cancer

21 January 2018

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Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma

21 January 2018

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Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation

21 January 2018

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Aldehyde dehydrogenase (ALDH) activity does not select for cells with enhanced aggressive properties in malignant melanoma

21 January 2018

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A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers

21 January 2018

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Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

21 January 2018

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Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists

21 January 2018

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ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome

21 January 2018

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Heterogeneous phenotype of human melanoma cells with in vitro and in vivo features of tumor-initiating cells

21 January 2018

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Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis

21 January 2018

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Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling

21 January 2018

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High aldehyde dehydrogenase activity identifies tumor-initiating and metastasis-initiating cells in human prostate cancer

21 January 2018

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Species variations in cutaneous alcohol dehydrogenases and aldehyde dehydrogenases may impact on toxicological assessments of alcohols and aldehydes

21 January 2018

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Selective modulation of Hedgehog/GLI target gene expression by epidermal growth factor signaling in human keratinocytes.

21 January 2018

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Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo

21 January 2018

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GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation

21 January 2018

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Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour-initiating pancreatic cancer cells

21 January 2018

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Cyclopamine and related steroidal alkaloid teratogens: their occurrence, structural relationship, and biologic effects

21 January 2018

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Teratogen-mediated inhibition of target tissue response to Shh signaling

21 January 2018

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Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling

21 January 2018

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Inhibition of GLI, but not Smoothened, induces apoptosis in chronic lymphocytic leukemia cells.

21 January 2018

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Hedgehog signaling drives cellular survival in human colon carcinoma cells

21 January 2018

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Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

21 January 2018

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Melanoma spheroids grown under neural crest cell conditions are highly plastic migratory/invasive tumor cells endowed with immunomodulator function

21 January 2018

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Reprogramming metastatic tumour cells with embryonic microenvironments

21 January 2018

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Cancer stem cells and human malignant melanoma

21 January 2018

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A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth

21 January 2018

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Mitf is the key molecular switch between mouse or human melanoma initiating cells and their differentiated progeny.

21 January 2018

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Inhibition of aldehyde dehydrogenase (ALDH) activity reduces chemotherapy and radiation resistance of stem-like ALDHhiCD44⁺ human breast cancer cells

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/STEM.1160

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11 September 2017

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