(Q39353575)

11 September 2017

Endogenous c-Myc is essential for p53-induced apoptosis in response to DNA damage in vivo (English)

1 reference

11 September 2017

0 references

1 reference

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24583641%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Toby J Phesse

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24583641%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Helen B Pearson

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24583641%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

author name string

K B Myant

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24583641%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

A M Cole

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24583641%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

R A Ridgway

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24583641%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

V Muncan

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24583641%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

G R van den Brink

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24583641%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

K H Vousden

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24583641%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

R Sears

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24583641%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

L T Vassilev

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24583641%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

A R Clarke

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24583641%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

publication date

28 February 2014

1 reference

Cell Death & Differentiation

11 September 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24583641%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

volume

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24583641%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24583641%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

page(s)

956-966

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24583641%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/cdd.2014.15

8 June 2020

exact match

0 references

cites work

Targeting MYC dependence in cancer by inhibiting BET bromodomains

1 reference

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Wnt/Myc interactions in intestinal cancer: partners in crime

11 September 2017

1 reference

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Mechanistic insight into Myc stabilization in breast cancer involving aberrant Axin1 expression

11 September 2017

1 reference

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Endogenous Myc maintains the tumor microenvironment

11 September 2017

1 reference

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Phosphorylation regulates c-Myc's oncogenic activity in the mammary gland.

11 September 2017

1 reference

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p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication

11 September 2017

1 reference

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Distinct thresholds govern Myc's biological output in vivo

11 September 2017

1 reference

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Apoptotic signaling by c-MYC.

11 September 2017

1 reference

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Modelling Myc inhibition as a cancer therapy

11 September 2017

1 reference

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C-Myc is a critical mediator of the phenotypes of Apc loss in the intestine

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013513

c-Myc and caspase-2 are involved in activating Bax during cytotoxic drug-induced apoptosis

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013513

Myc deletion rescues Apc deficiency in the small intestine

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013513

MDM2 inhibitors for cancer therapy

11 September 2017

1 reference

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Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc

11 September 2017

1 reference

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Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013513

ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013513

c-Myc is required for the formation of intestinal crypts but dispensable for homeostasis of the adult intestinal epithelium

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013513

The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma.

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013513

Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013513

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013513

MBD4 deficiency reduces the apoptotic response to DNA-damaging agents in the murine small intestine

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013513

c-Myc Augments Gamma Irradiation-Induced Apoptosis by Suppressing Bcl-XL

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013513

Analysis of C-MYC function in normal cells via conditional gene-targeted mutation

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013513

P53 null mice: damaging the hypothesis?

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013513

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013513

INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53.

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013513

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013513

An alternative pathway for gene regulation by Myc

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013513

Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013513

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013513

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013513

Induction of apoptosis in fibroblasts by c-myc protein

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013513

Bax is a transcriptional target and mediator of c-myc-induced apoptosis.

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013513

Faithful activation of an extra-bright red fluorescent protein in "knock-in" Cre-reporter mice ideally suited for lineage tracing studies.

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013513

Nucleolin inhibits Hdm2 by multiple pathways leading to p53 stabilization.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013513

Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013513

Mediation of c-Myc-induced apoptosis by p53.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013513

c-Myc represses the proximal promoters of GADD45a and GADD153 by a post-RNA polymerase II recruitment mechanism

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013513

A highly efficient ligand-regulated Cre recombinase mouse line shows that LoxP recombination is position dependent

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013513

Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013513

Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013513

Bcl-xL gain of function and p19 ARF loss of function cooperate oncogenically with Myc in vivo by distinct mechanisms

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013513

Onzin, a c-Myc-repressed target, promotes survival and transformation by modulating the Akt-Mdm2-p53 pathway.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013513

The ability to engage enterocyte apoptosis does not predict long-term crypt survival in p53 and Msh2 deficient mice

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013513

p53 dependence of early apoptotic and proliferative responses within the mouse intestinal epithelium following gamma-irradiation.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4013513

Myc suppression of the p21 Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage

21 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FCDD.2014.15

Caspase activation during spontaneous and radiation-induced apoptosis in the murine intestine

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24583641

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Methods for the isolation of intact epithelium from the mouse intestine

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24583641

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/CDD.2014.15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24583641%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24583641%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24583641%20AND%20SRC:MED&resulttype=core&format=json