(Q40271670)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16751805%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

title

Nucleolin inhibits Hdm2 by multiple pathways leading to p53 stabilization (English)

1 reference

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29 January 2020

1

1 reference

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29 January 2020

James A Borowiec

5

1 reference

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29 January 2020

author name string

C J Rorie

2

1 reference

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29 January 2020

D Dimitrova

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16751805%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

Y Daniely

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16751805%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

language of work or name

English

0 references

publication date

5 June 2006

1 reference

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29 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16751805%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

volume

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16751805%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

issue

55

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29 January 2020

page(s)

7274-7288

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16751805%20AND%20SRC:MED&resulttype=core&format=json

Physical and functional interactions of the Arf tumor suppressor protein with nucleophosmin/B23

29 January 2020

cites work

1 reference

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Essential role of ribosomal protein L11 in mediating growth inhibition-induced p53 activation

21 January 2018

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Post-translational modification of p53 in tumorigenesis

21 January 2018

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Major nucleolar proteins shuttle between nucleus and cytoplasm

21 January 2018

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Xenopus U3 snoRNA docks on pre-rRNA through a novel base-pairing interaction

21 January 2018

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Interrelations between the maturation of a 100 kDa nucleolar protein and pre rRNA synthesis in CHO cells

21 January 2018

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Requirement for p53 and p21 to sustain G2 arrest after DNA damage

21 January 2018

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ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor

21 January 2018

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Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5

21 January 2018

1 reference

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Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition

21 January 2018

1 reference

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Formation of a complex between nucleolin and replication protein A after cell stress prevents initiation of DNA replication

21 January 2018

1 reference

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Stress-dependent nucleolin mobilization mediated by p53-nucleolin complex formation

21 January 2018

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E1A signaling to p53 involves the p19(ARF) tumor suppressor

21 January 2018

1 reference

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

21 January 2018

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The ubiquitin ligase COP1 is a critical negative regulator of p53

21 January 2018

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Effects of anti-C23 (nucleolin) antibody on transcription of ribosomal DNA in Chironomus salivary gland cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

Nucleolin functions in the first step of ribosomal RNA processing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

Myc induces the nucleolin and BN51 genes: possible implications in ribosome biogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

YY1 inhibits the activation of the p53 tumor suppressor in response to genotoxic stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

Polyubiquitination of p53 by a ubiquitin ligase activity of p300.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

gar2 is a nucleolar protein fromSchizosaccharomyces pomberequired for 18S rRNA and 40S ribosomal subunit accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

Mdm2 promotes the rapid degradation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

Inhibition of HDM2 and activation of p53 by ribosomal protein L23

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

Novel checkpoint response to genotoxic stress mediated by nucleolin-replication protein a complex formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

Nucleophosmin (B23) targets ARF to nucleoli and inhibits its function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

ARF function does not require p53 stabilization or Mdm2 relocalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

Regulation of p53 stability by Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

NSR1 is required for pre-rRNA processing and for the proper maintenance of steady-state levels of ribosomal subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

A dynamic role of HAUSP in the p53-Mdm2 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

Regulation of HDM2 activity by the ribosomal protein L11

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

Tumor suppression by Ink4a-Arf: progress and puzzles

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

mdm2 Is critical for inhibition of p53 during lymphopoiesis and the response to ionizing irradiation

21 January 2018

1 reference

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An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo

21 January 2018

1 reference

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The MDM2 gene amplification database

21 January 2018

1 reference

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The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

21 January 2018

1 reference

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Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

21 January 2018

1 reference

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At the crossroads of growth control; making ribosomal RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

An apoptotic defect in lens differentiation caused by human p53 is rescued by a mutant allele

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

Alterations in the INK4a/ARF locus and their effects on the growth of human osteosarcoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

p19(Arf) induces p53-dependent apoptosis during abelson virus-mediated pre-B cell transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

SUMO-1 modification activates the transcriptional response of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

Does the ribosome translate cancer?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

A plant snoRNP complex containing snoRNAs, fibrillarin, and nucleolin-like proteins is competent for both rRNA gene binding and pre-rRNA processing in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

Preferential cleavage in pre-ribosomal RNA byprotein B23 endoribonuclease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

Identification of nucleolin as an AU-rich element binding protein involved in bcl-2 mRNA stabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

Nucleolar Arf tumor suppressor inhibits ribosomal RNA processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

p19(ARF) is dispensable for oncogenic stress-induced p53-mediated apoptosis and tumor suppression in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

p53 mutant mice that display early ageing-associated phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

Replication protein A (RPA) phosphorylation prevents RPA association with replication centers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

The oncogenic potential of Kaposi's sarcoma-associated herpesvirus cyclin is exposed by p53 loss in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

p53 Activation by nitric oxide involves down-regulation of Mdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

Regulation of dna replication after heat shock by replication protein a-nucleolin interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

Nucleolar Arf sequesters Mdm2 and activates p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

How the nucleolar sequestration of p53 protein or its interplayers contributes to its (re)-activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

Identification of nucleolin and nucleophosmin as genotoxic stress-responsive RNA-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

Ribosomal Protein L11 Negatively Regulates Oncoprotein MDM2 and Mediates a p53-Dependent Ribosomal-Stress Checkpoint Pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

Inhibition of NF-kappa B stabilizes gadd45 alpha mRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

p19ARF links the tumour suppressor p53 to Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

Testicular wild-type p53 expression in transgenic mice induces spermiogenesis alterations ranging from differentiation defects to apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

7 January 2021

Wild-type p53 transgenic mice exhibit altered differentiation of the ureteric bud and possess small kidneys

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

7 January 2021

Transcription by RNA polymerase I.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

7 January 2021

RB regulates the stability and the apoptotic function of p53 via MDM2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

7 January 2021

Sensing cellular stress: another new function for the nucleolus?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

7 January 2021

Amount of the two major Ag-NOR proteins, nucleolin, and protein B23 is cell-cycle dependent

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

7 January 2021

Yin Yang 1 is a negative regulator of p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209714

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1209714

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16751805%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

29 January 2020

1021733424

0 references

1 reference