(Q40739242)

23 September 2017

title

Alterations in the INK4a/ARF locus and their effects on the growth of human osteosarcoma cell lines (English)

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23 September 2017

Yong-Bum Park

1

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23 September 2017

Myung Jae Park

2

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23 September 2017

Kenji Kimura

3

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23 September 2017

Kimihiro Shimizu

4

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23 September 2017

Sang Hoon Lee

5

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23 September 2017

Jun Yokota

6

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23 September 2017

publication date

1 March 2002

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Cancer Genetics and Cytogenetics

23 September 2017

published in

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23 September 2017

volume

133

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23 September 2017

issue

2

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23 September 2017

page(s)

105-111

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A cell cycle regulator potentially involved in genesis of many tumor types

23 September 2017

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Comparative analysis of Homo sapiens and Mus musculus cyclin-dependent kinase (CDK) inhibitor genes p16 (MTS1) and p15 (MTS2)

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Role of the INK4a locus in tumor suppression and cell mortality.

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Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function

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Growth suppression by p16ink4 requires functional retinoblastoma protein

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7 January 2021

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

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7 January 2021

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

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7 January 2021

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

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7 January 2021

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

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7 January 2021

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

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7 January 2021

Inactivation of the INK4A/ARF locus frequently coexists with TP53 mutations in non-small cell lung cancer

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7 January 2021

Alterations and hypermethylation of the p14(ARF) gene in gastric cancer.

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7 January 2021

The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53.

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Methylation silencing and mutations of the p14ARF and p16INK4a genes in colon cancer

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7 January 2021

Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF.

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7 January 2021

Alterations of the p53, Rb and MDM2 genes in osteosarcoma

1 reference

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7 January 2021

CDKN2A gene deletions and loss of p16 expression occur in osteosarcomas that lack RB alterations

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7 January 2021

Differentiation induced by RB expression and apoptosis induced by p53 expression in an osteosarcoma cell line

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7 January 2021

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands

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7 January 2021

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7 January 2021

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7 January 2021

p53 functions as a cell cycle control protein in osteosarcomas

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7 January 2021

Alterations of the p15, p16,and p18 genes in osteosarcoma

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7 January 2021

Analysis of the p16INK4, p14ARF, p15, TP53, and MDM2 genes and their prognostic implications in osteosarcoma and Ewing sarcoma

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900575-1

7 January 2021

CDK4 gene amplification in osteosarcoma: reciprocal relationship with INK4A gene alterations and mapping of 12q13 amplicons

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900575-1

7 January 2021

Adenovirus-mediated p14(ARF) gene transfer in human mesothelioma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900575-1

7 January 2021

10.1016/S0165-4608(01)00575-1

Identifiers

DOI

1 reference

23 September 2017

1 reference