(Q28184745)

1

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Robert L Ludwig

2

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Michael H G Kubbutat

3

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Mary Hanlon

Stress signals utilize multiple pathways to stabilize p53

4

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language of work or name

English

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publication date

June 2003

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published in

Cancer Cell

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volume

3

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page(s)

577-87

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issue

6

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cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

mdm2 expression is induced by wild type p53 activity

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

Cell cycle arrest and DNA endoreduplication following p21Waf1/Cip1 expression

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

Hypophosphorylation of Mdm2 augments p53 stability

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

N-myc enhances the expression of a large set of genes functioning in ribosome biogenesis and protein synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

Defining the molecular basis of Arf and Hdm2 interactions

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

An intact HDM2 RING-finger domain is required for nuclear exclusion of p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

Nucleolar components involved in ribosome biogenesis cycle between the nucleolus and nucleoplasm in interphase cells

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

Ribosomal proteins in cell proliferation and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

The loss of mdm2 induces p53-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

A novel genetic system to detect protein-protein interactions

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

The MDM2 RING-finger domain is required to promote p53 nuclear export

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

Tyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulation

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

Identification of p53 sequence elements that are required for MDM2-mediated nuclear export

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

Characterization of a wheat cDNA encoding mitochondrial ribosomal protein L11: qualitative and quantitative tissue-specific differences in its expression

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

Mdm2 promotes the rapid degradation of p53

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

Ultraviolet radiation triggers the ribotoxic stress response in mammalian cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

ARF function does not require p53 stabilization or Mdm2 relocalization

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

Protein trans-acting factors involved in ribosome biogenesis in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

Regulation of p53 stability by Mdm2

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

Regulation of ribosome biogenesis within the nucleolus

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

Induction of ser15 and lys382 modifications of p53 by blockage of transcription elongation.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

Identification of a cryptic nucleolar-localization signal in MDM2

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

C-terminal ubiquitination of p53 contributes to nuclear export

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

Effects of valine deprivation on ribosome formation in HeLa cells

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

Amplification of a gene encoding a p53-associated protein in human sarcomas

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

Relationship between protein synthesis and ribosome assembly in HeLa cells

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

Inhibition of RNA synthesis by actinomycin D: Characteristic dose-response of different RNA species

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

Evidence of p53-dependent cross-talk between ribosome biogenesis and the cell cycle: effects of nucleolar protein Bop1 on G(1)/S transition

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

Two arginine rich domains in the p14ARF tumour suppressor mediate nucleolar localization.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

Regulation and function of the p53 tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

1 reference

7 January 2021

Quantitative proteomic analysis of Myc oncoprotein function

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

Inhibition of the processing of ribosomal precursor RNA by intercalating agents

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

Nucleolar Arf tumor suppressor inhibits ribosomal RNA processing

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

Regulation of the cell cycle by viral oncoproteins.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

1 reference

7 January 2021

Live or let die: the cell's response to p53

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

Murine double minute (MDM2) blocks p53-coactivator interaction, a new mechanism for inhibition of p53-dependent gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

Nucleolar Arf sequesters Mdm2 and activates p53

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

Regulation of p53 function

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

The p53-mdm-2 autoregulatory feedback loop

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

Scattering of the silver-stained proteins of nucleolar organizer regions in Ishikawa cells by actinomycin D

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

Repression of RNA polymerase I transcription by the tumor suppressor p53

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

Loss of ribosomal protein L11 blocks stress activation of the Bacillus subtilis transcription factor sigma(B).

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021

Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900134-X

7 January 2021