(Q39365706)

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Feasibility of implementing cell-based pathway reporter assays in early high-throughput screening assay cascades for antibody drug discovery

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scholarly article

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Europe PubMed Central

PubMed publication ID

11 September 2017

Feasibility of implementing cell-based pathway reporter assays in early high-throughput screening assay cascades for antibody drug discovery (English)

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Europe PubMed Central

PubMed publication ID

11 September 2017

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Tristan John Vaughan

6

object named as

Tristan J Vaughan

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Europe PubMed Central

PubMed publication ID

11 September 2017

author name string

Alison J Smith

1

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Europe PubMed Central

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11 September 2017

Michael K Hancock

2

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Europe PubMed Central

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11 September 2017

Kun Bi

3

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Europe PubMed Central

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11 September 2017

John Andrews

4

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Europe PubMed Central

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11 September 2017

Paula Harrison

5

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11 September 2017

publication date

11 April 2012

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Europe PubMed Central

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11 September 2017

Journal of Biomolecular Screening

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Europe PubMed Central

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11 September 2017

17

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11 September 2017

6

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11 September 2017

713-726

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PubMed publication ID

11 September 2017

Fundamentals of antibody-related therapy and diagnostics

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https://api.crossref.org/works/10.1177%2F1087057112442962

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Continuous cultures of fused cells secreting antibody of predefined specificity

1 reference

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High-throughput engineering of the mouse genome coupled with high-resolution expression analysis

1 reference

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Structure-function studies of two synthetic anti-vascular endothelial growth factor Fabs and comparison with the Avastin Fab.

1 reference

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Human monoclonal antibodies from transgenic mice

1 reference

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Selecting and screening recombinant antibody libraries

1 reference

https://api.crossref.org/works/10.1177%2F1087057112442962

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Beyond natural antibodies: the power of in vitro display technologies

1 reference

https://api.crossref.org/works/10.1177%2F1087057112442962

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Human antibodies with sub-nanomolar affinities isolated from a large non-immunized phage display library

1 reference

https://api.crossref.org/works/10.1177%2F1087057112442962

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High level production of soluble single chain antibodies in small-scale Escherichia coli cultures.

1 reference

https://api.crossref.org/works/10.1177%2F1087057112442962

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Antibodies from phage antibody libraries

1 reference

https://api.crossref.org/works/10.1177%2F1087057112442962

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The role of therapeutic antibodies in drug discovery

1 reference

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A cytokine-neutralizing antibody as a structural mimetic of 2 receptor interactions

1 reference

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Development of an intact cell reporter gene beta-lactamase assay for G protein-coupled receptors for high-throughput screening

1 reference

https://api.crossref.org/works/10.1177%2F1087057112442962

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Human monomeric antibody fragments to TRAIL-R1 and TRAIL-R2 that display potent in vitro agonism

1 reference

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Ligand detection in the allosteric world

1 reference

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A simple high-throughput purification method for hit identification in protein screening.

1 reference

https://api.crossref.org/works/10.1177%2F1087057112442962

21 January 2018

Single-chain Fv phage display propensity exhibits strong positive correlation with overall expression levels

1 reference

https://api.crossref.org/works/10.1177%2F1087057112442962

21 January 2018

Rapid kinetic-based screening of human Fab fragments

1 reference

https://api.crossref.org/works/10.1177%2F1087057112442962

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Current and future drugs targeting one class of innate immunity receptors: the Toll-like receptors

1 reference

https://api.crossref.org/works/10.1177%2F1087057112442962

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Toll-like receptors

1 reference

https://api.crossref.org/works/10.1177%2F1087057112442962

21 January 2018

LPS/TLR4 signal transduction pathway

1 reference

https://api.crossref.org/works/10.1177%2F1087057112442962

21 January 2018

Identification of small molecule compounds that inhibit the HIF-1 signaling pathway

1 reference

https://api.crossref.org/works/10.1177%2F1087057112442962

21 January 2018

An improved beta-lactamase reporter assay: multiplexing with a cytotoxicity readout for enhanced accuracy of hit identification

1 reference

https://api.crossref.org/works/10.1177%2F1087057112442962

21 January 2018

HTS assays using a disease-relevant cell model for interrogating the MAP kinase pathway initiated by multiple receptors

1 reference

https://api.crossref.org/works/10.1177%2F1087057112442962

21 January 2018

Differential role for c-Rel and C/EBPbeta/delta in TLR-mediated induction of proinflammatory cytokines

1 reference

https://api.crossref.org/works/10.1177%2F1087057112442962

21 January 2018

Hyperosmotic stress induces rapid focal adhesion kinase phosphorylation at tyrosines 397 and 577. Role of Src family kinases and Rho family GTPases

1 reference

https://api.crossref.org/works/10.1177%2F1087057112442962

21 January 2018

Hyperosmotic stress-induced ATF-2 activation through Polo-like kinase 3 in human corneal epithelial cells

1 reference

https://api.crossref.org/works/10.1177%2F1087057112442962

21 January 2018

Accumulation of E2F-4.DP-1 DNA binding complexes correlates with induction of dhfr gene expression during the G1 to S phase transition

1 reference

https://api.crossref.org/works/10.1177%2F1087057112442962

21 January 2018

Parallel activation of Ca(2+)-induced survival and death pathways in cardiomyocytes by sorbitol-induced hyperosmotic stress

1 reference

https://api.crossref.org/works/10.1177%2F1087057112442962

21 January 2018

Identifiers

10.1177/1087057112442962

1 reference

Europe PubMed Central

PubMed publication ID

11 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

11 September 2017

ResearchGate publication ID

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