(Q39384360)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22395339%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

title

Relaxation of the rigid backbone of an oligoamide-foldamer-based α-helix mimetic: identification of potent Bcl-xL inhibitors (English)

1 reference

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25 January 2020

3

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25 January 2020

Alex MacKerell

8

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25 January 2020

author name string

Jeremy L Yap

1

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25 January 2020

Xiaobo Cao

2

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25 January 2020

Kwan-Young Jung

4

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25 January 2020

Chander Peddaboina

5

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25 January 2020

Paul T Wilder

6

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25 January 2020

Anjan Nan

7

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25 January 2020

W Roy Smythe

9

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25 January 2020

Steven Fletcher

10

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25 January 2020

publication date

7 March 2012

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Organic and Biomolecular Chemistry

25 January 2020

published in

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25 January 2020

volume

10

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25 January 2020

issue

15

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25 January 2020

page(s)

2928-2933

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Helix-mediated protein--protein interactions as targets for intervention using foldamers

25 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1039%2FC2OB07125H

Disrupting protein-protein interactions with non-peptidic, small molecule alpha-helix mimetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB07125H

Synthetic non-peptide mimetics of alpha-helices

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB07125H

Protein surface recognition and proteomimetics: mimics of protein surface structure and function

21 January 2018

1 reference

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Toward proteomimetics: terphenyl derivatives as structural and functional mimics of extended regions of an alpha-helix

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB07125H

Development of a potent Bcl-x(L) antagonist based on alpha-helix mimicry

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB07125H

Terphenyl-Based Bak BH3 alpha-helical proteomimetics as low-molecular-weight antagonists of Bcl-xL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB07125H

Terphenyl-based helical mimetics that disrupt the p53/HDM2 interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB07125H

Design and application of an alpha-helix-mimetic scaffold based on an oligoamide-foldamer strategy: antagonism of the Bak BH3/Bcl-xL complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB07125H

N-alkylated oligoamide alpha-helical proteomimetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB07125H

Synthesis and biological evaluation of a 5-6-5 imidazole-phenyl-thiazole based alpha-helix mimetic

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB07125H

Heterocyclic alpha-helix mimetics for targeting protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB07125H

Synthesis of pyridazine-based scaffolds as alpha-helix mimetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB07125H

Cell death: critical control points

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB07125H

Bcl-2 family proteins and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB07125H

Bcl2/bcl-xL inhibitor engenders apoptosis and increases chemosensitivity in mesothelioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB07125H

Mcl-1 is critical for survival in a subgroup of non-small-cell lung cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB07125H

MiR-148a promotes apoptosis by targeting Bcl-2 in colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB07125H

The Bcl-2 apoptotic switch in cancer development and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB07125H

The Bcl-2 protein family: arbiters of cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB07125H

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB07125H

Bcl-2 inhibitors: small molecules with a big impact on cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB07125H

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB07125H

Acylpyrogallols as inhibitors of antiapoptotic Bcl-2 proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB07125H

Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB07125H

Controlling curvature in a family of oligoamide alpha-helix mimetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB07125H

Synthesis of functionalised aromatic oligamide rods

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB07125H

CHARMM: the biomolecular simulation program

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB07125H

Development of a high-throughput fluorescence polarization assay for Bcl-x(L)

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB07125H

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB07125H

Induction of apoptosis and down-regulation of Bcl-XL in cancer cells by a novel small molecule, 2[[3-(2,3-dichlorophenoxy)propyl]amino]ethanol

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB07125H

Up-regulation of Bcl-xl by hepatocyte growth factor in human mesothelioma cells involves ETS transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB07125H

Substituted 1,4-benzodiazepine-2,5-diones as alpha-helix mimetic antagonists of the HDM2-p53 protein-protein interaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB07125H

Concomitant inhibition of MDM2 and Bcl-2 protein function synergistically induce mitochondrial apoptosis in AML.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB07125H

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2OB07125H

21 January 2018

Identifiers

DOI

10.1039/C2OB07125H

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22395339%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

1 reference