(Q37853442)

24 August 2017

1 reference

title

Helix-mediated protein--protein interactions as targets for intervention using foldamers (English)

1 reference

24 August 2017

1

Thomas A Edwards

0 references

author name string

Andrew J Wilson

series ordinal

2

1 reference

24 August 2017

publication date

17 March 2011

1 reference

24 August 2017

1 reference

24 August 2017

volume

41

1 reference

24 August 2017

issue

3

1 reference

24 August 2017

page(s)

743-754

1 reference

Molecular Recognition of Protein−Ligand Complexes: Applications to Drug Design

24 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Coupling of receptor conformation and ligand orientation determine graded activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

N-alkylated oligoamide alpha-helical proteomimetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Core structure of gp41 from the HIV envelope glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

beta-Peptides: from structure to function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Disrupting protein-protein interactions with non-peptidic, small molecule alpha-helix mimetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Dude, where's my phenotype? Dealing with redundancy in signaling networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Structural insights into the degradation of Mcl-1 induced by BH3 domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Cell death: critical control points

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Structure of the carboxyl-terminal dimerization domain of the HIV-1 capsid protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Foldamers as versatile frameworks for the design and evolution of function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Beta-peptides with improved affinity for hDM2 and hDMX.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Downsizing human, bacterial, and viral proteins to short water-stable alpha helices that maintain biological potency

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Androgen receptor in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Inhibition of hypoxia inducible factor 1-transcription coactivator interaction by a hydrogen bond surrogate alpha-helix

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

High Specificity in Protein Recognition by Hydrogen‐Bond‐Surrogate α‐Helices: Selective Inhibition of the p53/MDM2 Complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Estrogen receptor mutations in human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Sequence-based design of alpha/beta-peptide foldamers that mimic BH3 domains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Structural and biological mimicry of protein surface recognition by / -peptide foldamers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Assessment of helical interfaces in protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Systematic analysis of helical protein interfaces reveals targets for synthetic inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Principles of protein-protein interactions: what are the preferred ways for proteins to interact?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Helical beta-peptide inhibitors of the p53-hDM2 interaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

The structure of a Bcl-xL/Bim fragment complex: implications for Bim function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Direct inhibition of the NOTCH transcription factor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Notch signaling: from the outside in

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Chromatin crosstalk in development and disease: lessons from REST

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Toward proteomimetics: terphenyl derivatives as structural and functional mimics of extended regions of an alpha-helix

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Synthesis of functionalised aromatic oligamide rods

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Oligobenzamide proteomimetic inhibitors of the p53-hDM2 protein-protein interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Atomic-level modelling of the HIV capsid

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Functional consequences of the Kaposi's sarcoma-associated herpesvirus protease structure: regulation of activity and dimerization by conserved structural elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

21 January 2018

Peptidomimetic design

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Benzoylurea oligomers: synthetic foldamers that mimic extended alpha helices

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

p53--a natural cancer killer: structural insights and therapeutic concepts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

alpha-Helix mimetics as inhibitors of protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Controlling curvature in a family of oligoamide alpha-helix mimetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Target-oriented and diversity-oriented organic synthesis in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

The world of beta- and gamma-peptides comprised of homologated proteinogenic amino acids and other components

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Design, synthesis, and evaluation of an alpha-helix mimetic library targeting protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Inhibition of a viral enzyme by a small-molecule dimer disruptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Modular alpha-helical mimetics with antiviral activity against respiratory syncitial virus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Short constrained peptides that inhibit HIV-1 entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Inhibiting HIV fusion with a beta-peptide foldamer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Proteolytic refolding of the HIV-1 capsid protein amino-terminus facilitates viral core assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Enhanced metabolic stability and protein-binding properties of artificial alpha helices derived from a hydrogen-bond surrogate: application to Bcl-xL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Inhibition of protein-protein interactions using designed molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Structures of the HIV-1 capsid protein dimerization domain at 2.6 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Modulation of Notch signaling by mastermind-like (MAML) transcriptional co-activators and their involvement in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Terphenyl-Based Bak BH3 alpha-helical proteomimetics as low-molecular-weight antagonists of Bcl-xL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Structural characterization of the human respiratory syncytial virus fusion protein core

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

Protein−Protein Interactions: Interface Structure, Binding Thermodynamics, and Mutational Analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-011-0880-8

10.1007/S00726-011-0880-8

21 January 2018

Identifiers

DOI

1 reference

24 August 2017

1 reference