(Q39385211)

11 September 2017

title

A potent Chk1 inhibitor is selectively cytotoxic in melanomas with high levels of replicative stress (English)

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11 September 2017

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K Brooks

1

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11 September 2017

V Oakes

2

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11 September 2017

B Edwards

3

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11 September 2017

M Ranall

4

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11 September 2017

P Leo

5

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S Pavey

6

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11 September 2017

A Pinder

7

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11 September 2017

H Beamish

8

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11 September 2017

P Mukhopadhyay

9

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11 September 2017

D Lambie

10

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11 September 2017

B Gabrielli

11

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11 September 2017

language of work or name

English

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publication date

5 March 2012

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11 September 2017

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11 September 2017

volume

32

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11 September 2017

issue

6

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11 September 2017

page(s)

788-796

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https://scigraph.springernature.com/pub.10.1038/onc.2012.72

11 September 2017

exact match

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cites work

Checkpoint genes in cancer.

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Cell-cycle dysregulation and anticancer therapy

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Checkpoint mechanisms at the intersection between DNA damage and repair

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The concept of synthetic lethality in the context of anticancer therapy

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New insights into checkpoint kinase 1 in the DNA damage response signaling network

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Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems

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The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair

21 January 2018

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Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.72

Chk1 inhibits replication factory activation but allows dormant origin firing in existing factories.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.72

Chk1 promotes replication fork progression by controlling replication initiation

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.72

Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.72

Chk1-dependent regulation of Cdc25B functions to coordinate mitotic events

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Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics

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The G(2) DNA damage checkpoint: could this ancient regulator be the Achilles heel of cancer?

21 January 2018

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Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair.

21 January 2018

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Chk1 Kinase Negatively Regulates Mitotic Function of Cdc25A Phosphatase through 14-3-3 Binding

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.72

Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.72

Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

21 January 2018

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Checkpoint kinase inhibitors: a patent review (2009 - 2010).

21 January 2018

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Single-agent inhibition of Chk1 is antiproliferative in human cancer cell lines in vitro and inhibits tumor xenograft growth in vivo

21 January 2018

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A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.72

Depletion of Chk1 leads to premature activation of Cdc2-cyclin B and mitotic catastrophe

21 January 2018

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Checkpoint kinase 1 (Chk1) is required for mitotic progression through negative regulation of polo-like kinase 1 (Plk1)

21 January 2018

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Histone deacetylase inhibitors specifically kill nonproliferating tumour cells

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Chk1 inhibition after replicative stress activates a double strand break response mediated by ATM and DNA-dependent protein kinase

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.72

The DNA-damage effector checkpoint kinase 1 is essential for chromosome segregation and cytokinesis

21 January 2018

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Spindle checkpoint function is required for mitotic catastrophe induced by DNA-damaging agents

21 January 2018

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Caffeine promotes apoptosis in mitotic spindle checkpoint-arrested cells

21 January 2018

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Cell death by mitotic catastrophe: a molecular definition

21 January 2018

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Mechanisms of mitotic cell death induced by chemotherapy-mediated G2 checkpoint abrogation.

21 January 2018

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ATR and Chk1 suppress a caspase-3-dependent apoptotic response following DNA replication stress

21 January 2018

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Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3.

21 January 2018

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Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

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Regulation of the G2/M transition by p53.

21 January 2018

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Adaptation and validation of DNA synthesis detection by fluorescent dye derivatization for high-throughput screening.

21 January 2018

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Expression of gamma-H2AX in melanocytic lesions

21 January 2018

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Histone deacetylase inhibitors induce mitotic slippage

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2012.72

31 March 2020

Identifiers

DOI

10.1038/ONC.2012.72

1 reference

11 September 2017

1 reference