(Q39385318)

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Flavopiridol induces phosphorylation of AKT in a human glioblastoma cell line, in contrast to siRNA-mediated silencing of Cdk9: Implications for drug design and development.

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scholarly article

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25 January 2020

Flavopiridol induces phosphorylation of AKT in a human glioblastoma cell line, in contrast to siRNA-mediated silencing of Cdk9: Implications for drug design and development (English)

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25 January 2020

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phosphorylation

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Antonio Giordano

9

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25 January 2020

Annamaria Cimini

5

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25 January 2020

Valentina Caracciolo

1

object named as

Valentina Caracciolo

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25 January 2020

author name string

Giulio Laurenti

2

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25 January 2020

Gaetano Romano

3

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25 January 2020

Vincenzo Carnevale

4

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25 January 2020

Catena Crozier-Fitzgerald

6

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25 January 2020

Emilio Gentile Warschauer

7

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25 January 2020

Giuseppe Russo

8

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25 January 2020

publication date

15 March 2012

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25 January 2020

number of pages

15

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25 January 2020

11

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25 January 2020

6

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25 January 2020

1202-1216

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25 January 2020

PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in vitro

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

Regulatory functions of Cdk9 and of cyclin T1 in HIV Tat transactivation pathway gene expression

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

Role of the cyclin-dependent kinase 9-related pathway in mammalian gene expression and human diseases

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

Activation of MyoD-dependent transcription by cdk9/cyclin T2

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

Mammalian cyclin-dependent kinases

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

Cell cycle kinases in cancer

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

CDK inhibitors in cancer therapy: what is next?

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

A role for CDK9-cyclin K in maintaining genome integrity

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

Making a neuron: Cdk5 in embryonic and adult neurogenesis.

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

Human CDK10 gene isoforms

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

P-TEFb, a cyclin-dependent kinase controlling elongation by RNA polymerase II

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

CYCLINg through transcription: posttranslational modifications of P-TEFb regulate transcription elongation

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

A history of TFIIH: two decades of molecular biology on a pivotal transcription/repair factor.

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

Binding to DNA of the RNA-polymerase II C-terminal domain allows discrimination between Cdk7 and Cdk9 phosphorylation.

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

The role of the Cdk9/Cyclin T1 complex in T cell differentiation

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

Cyclin T: three forms for different roles in physiological and pathological functions

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

Cdk9, a member of the cdc2-like family of kinases, binds to gp130, the receptor of the IL-6 family of cytokines

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

Physical interaction between pRb and cdk9/cyclinT2 complex

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

Cdk9 phosphorylates p53 on serine 392 independently of CKII.

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

Transcriptional activity of positive transcription elongation factor b kinase in vivo requires the C-terminal domain of RNA polymerase II.

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

Positive transcription elongation factor B phosphorylates hSPT5 and RNA polymerase II carboxyl-terminal domain independently of cyclin-dependent kinase-activating kinase.

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

Androgen receptor interacts with the positive elongation factor P-TEFb and enhances the efficiency of transcriptional elongation

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

EBV EBNA 2 stimulates CDK9-dependent transcription and RNA polymerase II phosphorylation on serine 5.

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

Tax interacts with P-TEFb in a novel manner to stimulate human T-lymphotropic virus type 1 transcription

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

Role of cdk9 in the optimization of expression of the genes regulated by ICP22 of herpes simplex virus 1

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

Requirement for a kinase-specific chaperone pathway in the production of a Cdk9/cyclin T1 heterodimer responsible for P-TEFb-mediated tat stimulation of HIV-1 transcription

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

Abrogation of signal-dependent activation of the cdk9/cyclin T2a complex in human RD rhabdomyosarcoma cells

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

CDK9/CYCLIN T1 expression during normal lymphoid differentiation and malignant transformation.

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

Cyclin T1 overexpression induces malignant transformation and tumor growth

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

Antiapoptotic function of Cdk9 (TAK/P-TEFb) in U937 promonocytic cells

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

Identification of multiple cyclin subunits of human P-TEFb

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

Transcription inhibition by flavopiridol: mechanism of chronic lymphocytic leukemia cell death

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

Dissociation between resistance to apoptosis and the transformed phenotype in IGF-I receptor signaling.

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

Insulin and IGF-I receptors signaling in protection from apoptosis

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

Analysis of the epidermal growth factor receptor specific transcriptome: effect of receptor expression level and an activating mutation

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

Autocrine/paracrine secreted Frizzled-related protein 2 induces cellular resistance to apoptosis: a possible mechanism of mammary tumorigenesis

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

Transformation of interleukin-3-dependent cells without participation of Stat5/bcl-xL: cooperation of akt with raf/erk leads to p65 nuclear factor kappaB-mediated antiapoptosis involving c-IAP2.

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

The phosphatidylinositol 3-kinase/Akt/mTOR signaling network as a therapeutic target in acute myelogenous leukemia patients.

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

MRE11 promotes AKT phosphorylation in direct response to DNA double-strand breaks.

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

Survivin expression and its relation with proliferation, apoptosis, and angiogenesis in brain gliomas.

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

Cdk9 regulates neural differentiation and its expression correlates with the differentiation grade of neuroblastoma and PNET tumors.

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

The CDK inhibitors: potential targets for therapeutic stem cell manipulations?

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

Flavopiridol, an inhibitor of transcription: implications, problems and solutions

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

Flavopiridol induces p53 via initial inhibition of Mdm2 and p21 and, independently of p53, sensitizes apoptosis-reluctant cells to tumor necrosis factor

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

8-Amino-adenosine inhibits multiple mechanisms of transcription

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

CDK9 a potential target for drug development.

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

Cyclin-dependent kinase inhibitors as anticancer drugs.

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

Cell death induction in resting lymphocytes by pan-Cdk inhibitor, but not by Cdk4/6 selective inhibitor

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

AKT signaling in normal and malignant cells

1 reference

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21 January 2018

Akt is activated in chronic lymphocytic leukemia cells and delivers a pro-survival signal: the therapeutic potential of Akt inhibition

1 reference

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21 January 2018

Dopaminergic and glutamatergic signaling crosstalk in Huntington's disease neurodegeneration: the role of p25/cyclin-dependent kinase 5.

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

Roscovitine reduces neuronal loss, glial activation, and neurologic deficits after brain trauma

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

The role of CDK5/P25 formation/inhibition in neurodegeneration

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

Interplay between the p53 tumor suppressor protein family and Cdk5: novel therapeutic approaches for the treatment of neurodegenerative diseases using selective Cdk inhibitors

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

Limited redundancy in genes regulated by Cyclin T2 and Cyclin T1.

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

Effects of prostratin on Cyclin T1/P-TEFb function and the gene expression profile in primary resting CD4+ T cells

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

Radiation-induced Akt activation modulates radioresistance in human glioblastoma cells

1 reference

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21 January 2018

Therapeutic strategies to target multiple kinases in glioblastoma

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.6.19663

21 January 2018

Heterogeneity of anticancer drug sensitivity in squamous cell carcinoma of the tongue.

1 reference

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21 January 2018

ASPM and microcephalin expression in epithelial ovarian cancer correlates with tumour grade and survival

1 reference

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21 January 2018

Dynamics of cancer cell subpopulations in primary and metastatic colorectal tumors

1 reference

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21 January 2018

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