(Q36996128)

17 August 2017

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title

The CDK inhibitors: potential targets for therapeutic stem cell manipulations? (English)

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17 August 2017

1

M J Boyer

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17 August 2017

T Cheng

2

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17 August 2017

8 November 2007

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17 August 2017

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17 August 2017

15

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17 August 2017

2

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17 August 2017

117-125

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https://scigraph.springernature.com/pub.10.1038/sj.gt.3303064

17 August 2017

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cites work

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21 January 2018

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21 January 2018

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Inhibitors of mammalian G1 cyclin-dependent kinases

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

G1 phase progression: cycling on cue

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Atm selectively regulates distinct p53-dependent cell-cycle checkpoint and apoptotic pathways.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

The relative quiescence of hematopoietic stem cells in nonhuman primates

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Existence of slow-cycling limbal epithelial basal cells that can be preferentially stimulated to proliferate: implications on epithelial stem cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Capturing and profiling adult hair follicle stem cells.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Mouse epidermal stem cells proceed through the cell cycle

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Subventricular zone astrocytes are neural stem cells in the adult mammalian brain

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

In vitro self-renewal division of hematopoietic stem cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Different in vivo repopulating activities of purified hematopoietic stem cells before and after being stimulated to divide in vitro with the same kinetics

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Cell cycle inhibitors in normal and tumor stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

The retinoblastoma tumour suppressor in development and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

In vivo self-renewing divisions of haematopoietic stem cells are increased in the absence of the early G1-phase inhibitor, p18INK4C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Stem cell repopulation efficiency but not pool size is governed by p27(kip1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

WAF1, a potential mediator of p53 tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Ex vivo targeting of p21Cip1/Waf1 permits relative expansion of human hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Silencing p21(Waf1/Cip1/Sdi1) expression increases gene transduction efficiency in primitive human hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

A Limited role for p21Cip1/Waf1 in maintaining normal hematopoietic stem cell functioning.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

p21Cip1 levels differentially regulate turnover of mature endothelial cells, endothelial progenitor cells, and in vivo neovascularization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Opposing roles for p21(waf1/cip1) and p27(kip1) in enterocyte differentiation, proliferation, and migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

p21 loss compromises the relative quiescence of forebrain stem cell proliferation leading to exhaustion of their proliferation capacity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Regenerative response in ischemic brain restricted by p21cip1/waf1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Notch1 modulates timing of G1-S progression by inducing SKP2 transcription and p27 Kip1 degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

shRNA knockdown of Bmi-1 reveals a critical role for p21-Rb pathway in NSC self-renewal during development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Reduction in levels of the cyclin-dependent kinase inhibitor p27(kip-1) coupled with transforming growth factor beta neutralization induces cell-cycle entry and increases retroviral transduction of primitive human hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Transforming growth factor beta 1 mediates cell-cycle arrest of primitive hematopoietic cells independent of p21(Cip1/Waf1) or p27(Kip1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Negative cell-cycle regulators cooperatively control self-renewal and differentiation of haematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Loss of p27(Kip1) enhances the transplantation efficiency of hepatocytes transferred into diseased livers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

p57Kip2 is expressed in quiescent mouse bone marrow side population cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Cytokine signals modulated via lipid rafts mimic niche signals and induce hibernation in hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

p57 and Hes1 coordinate cell cycle exit with self-renewal of pancreatic progenitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

p57Kip2 is induced by MyoD through a p73-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

p18Ink4c collaborates with Men1 to constrain lung stem cell expansion and suppress non-small-cell lung cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Steel factor responsiveness regulates the high self-renewal phenotype of fetal hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Hematopoietic stem cell exhaustion impacted by p18 INK4C and p21 Cip1/Waf1 in opposite manners

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Stem cells, cancer, and cancer stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Prospective identification of tumorigenic breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Prospective identification of tumorigenic prostate cancer stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Identification of human brain tumour initiating cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

The murine gene p27Kip1 is haplo-insufficient for tumour suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Haploinsufficiency of p18(INK4c) sensitizes mice to carcinogen-induced tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Hematopoietic stem cells are not the direct target of spontaneous leukemic transformation in p18(INK4C)-null reconstituted mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Cyclin-dependent kinases: inhibition and substrate recognition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Structural consequences of tumor-derived mutations in p16INK4a probed by limited proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Genetic evidence for functional dependency of p18Ink4c on Cdk4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Inhibition of pRb phosphorylation and cell-cycle progression by a 20-residue peptide derived from p16CDKN2/INK4A

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Cip/Kip cell-cycle inhibitors: a neuro-oncological perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

ErbB2/Neu-induced, cyclin D1-dependent transformation is accelerated in p27-haploinsufficient mammary epithelial cells but impaired in p27-null cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

A critical role for p27kip1 gene dosage in a mouse model of prostate carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Regulation of the cdk inhibitor p27 and its deregulation in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

p21(Waf1/Cip1) is an assembly factor required for platelet-derived growth factor-induced vascular smooth muscle cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

p21Waf1/Cip1 as a therapeutic target in breast and other cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

A recombinant adenovirus expressing p27Kip1 induces cell cycle arrest and loss of cyclin-Cdk activity in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Downregulation of Skp2 and p27/Kip1 synergistically induces apoptosis in T98G glioblastoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Testing the importance of p27 degradation by the SCFskp2 pathway in murine models of lung and colon cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith–Wiedemann syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

Neural stem cells in the adult mammalian forebrain: a relatively quiescent subpopulation of subependymal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

7 January 2021

Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

7 January 2021

CDK inhibitors p18(INK4c) and p27(Kip1) mediate two separate pathways to collaboratively suppress pituitary tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

7 January 2021

INK4d-deficient mice are fertile despite testicular atrophy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

7 January 2021

Hematopoietic stem cell quiescence maintained by p21cip1/waf1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

7 January 2021

p21 is essential for normal myogenic progenitor cell function in regenerating skeletal muscle

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

7 January 2021

Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

7 January 2021

Lack of the cell-cycle inhibitor p27Kip1 results in selective increase of transit-amplifying cells for adult neurogenesis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

7 January 2021

CDK inhibitors: positive and negative regulators of G1-phase progression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

1 reference

7 January 2021

Tumor growth need not be driven by rare cancer stem cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

7 January 2021

Tumor suppression and inhibition of aneuploid cell accumulation in human brain tumor cells by ectopic overexpression of the cyclin-dependent kinase inhibitor p27KIP1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

7 January 2021

RNA silencing of S-phase kinase-interacting protein 2 inhibits proliferation and centrosome amplification in lung cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3303064

7 January 2021

Identifiers

DOI

10.1038/SJ.GT.3303064

1 reference

17 August 2017

1 reference

PubMed ID

17989702