(Q36604805)

English

Interplay between the p53 tumor suppressor protein family and Cdk5: novel therapeutic approaches for the treatment of neurodegenerative diseases using selective Cdk inhibitors

scientific article published on August 2006

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scholarly article

1 reference

Europe PubMed Central

15 August 2017

1 reference

Europe PubMed Central

Interplay between the p53 tumor suppressor protein family and Cdk5: novel therapeutic approaches for the treatment of neurodegenerative diseases using selective Cdk inhibitors (English)

1 reference

Europe PubMed Central

15 August 2017

1 reference

based on heuristic

inferred from title

neurodegeneration

1 reference

based on heuristic

inferred from title

Józefa Wesierska-Gadek

3

object named as

Józefa Wesierska-Gadek

0 references

Joanna B Strosznajder

2

object named as

Joanna B Strosznajder

1 reference

Europe PubMed Central

15 August 2017

author name string

Gerald Schmid

1

1 reference

Europe PubMed Central

15 August 2017

publication date

1 August 2006

1 reference

Europe PubMed Central

15 August 2017

Molecular Neurobiology

1 reference

Europe PubMed Central

15 August 2017

34

1 reference

Europe PubMed Central

15 August 2017

1

1 reference

Europe PubMed Central

15 August 2017

27-50

1 reference

Europe PubMed Central

15 August 2017

https://scigraph.springernature.com/pub.10.1385/mn:34:1:27

0 references

Recent progress in the discovery and development of cyclin-dependent kinase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Site-specific phosphorylation of synapsin I by mitogen-activated protein kinase and Cdk5 and its effects on physiological functions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Callosal axon guidance defects in p35(-/-) mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a p53-dependent negative response element in the bcl-2 gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 activation domain 1 is essential for PUMA upregulation and p53-mediated neuronal cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 leans on its siblings

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cdk5 phosphorylates p53 and regulates its activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclin-dependent Kinase 5 (Cdk5) Activation Domain of Neuronal Cdk5 Activator

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclin-dependent kinases as potential targets to improve stroke outcome.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel disruption of cortical development in p35(-/-) mice distinct from reeler.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of natural flavones and flavonols on the kinase activity of Cdk5.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An Isoform of the Neuronal Cyclin-dependent Kinase 5 (Cdk5) Activator

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T antigen is bound to a host protein in SY40-transformed cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Investigating the neuroprotective mechanism of action of a CDK5 inhibitor by phosphoproteome analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Attenuation of p53 expression protects against focal ischemic damage in transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of neuronal apoptosis by the cyclin-dependent kinase inhibitor GW8510: identification of 3' substituted indolones as a scaffold for the development of neuroprotective drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Different p73 splicing variants are expressed in distinct tumour areas of a multifocal neuroblastoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RB and Cdc2 expression in brain: correlations with 3H-thymidine incorporation and neurogenesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apaf1 is required for mitochondrial pathways of apoptosis and brain development

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA fragmentation indicative of apoptosis following unilateral cerebral hypoxia-ischemia in the neonatal rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wild-type p53 binds to the TATA-binding protein and represses transcription

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oncogene-dependent regulation of caspase activation by p53 protein in a cell-free system

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p63 is a p53 homologue required for limb and epidermal morphogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DeltaN-p53, a natural isoform of p53 lacking the first transactivation domain, counteracts growth suppression by wild-type p53.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The tumor suppressor p53 inhibits Net, an effector of Ras/extracellular signal-regulated kinase signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of the p53 tumor suppressor gene protects neurons from kainate-induced cell death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of homozygously inactivated p73 in single-copy MYCN primary neuroblastomas and neuroblastoma cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dual action of the inhibitors of cyclin-dependent kinases: targeting of the cell-cycle progression and activation of wild-type p53 protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nerve growth factor-induced accumulation of PC12 cells expressing cyclin D1: evidence for a G1 phase block

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cycling at the interface between neurodevelopment and neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased activity of p53 in senescing fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress-related proteins A170 and heme oxygenase-1 are differently induced in the rat cerebellum under kainate-mediated excitotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of the 23 kDa subunit of tau protein kinase II as a putative activator of cdk5 in bovine brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of tau phosphorylating protein kinase cdk5 prevents beta-amyloid-induced neuronal death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In situ labeling of granule cells for apoptosis-associated DNA fragmentation reveals different mechanisms of cell loss in developing cerebellum

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Poly(ADP-ribose) polymerase-1 and apoptosis inducing factor in neurotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress induces p53-mediated apoptosis in glia: p53 transcription-independent way to die.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A decade of CDK5.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of delayed cell death following hypoxic-ischemic injury in the immature rat: evidence for apoptosis during selective neuronal loss

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotrophin signal transduction in the nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of Munc-18/syntaxin 1A interaction by cyclin-dependent kinase 5 in nerve endings

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A subset of p53-deficient embryos exhibit exencephaly

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell cycle arrest and apoptosis induced by Notch1 in B cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spatiotemporal selectivity of response to Notch1 signals in mammalian forebrain precursors

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

WAF1, a potential mediator of p53 tumor suppression

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro and in vivo antitumor properties of the cyclin dependent kinase inhibitor CYC202 (R-roscovitine)

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cdk5, a therapeutic target for Alzheimer's disease?

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53, the cellular gatekeeper for growth and division

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunocytochemical study on the distribution of p53 in the hippocampus and cerebellum of the aged rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis of central and peripheral neurons can be prevented with cyclin-dependent kinase/mitogen-activated protein kinase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiological ageing: role of p53 and PARP-1 tumor suppressors in the regulation of terminal senescence.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlating notch signaling with thymocyte maturation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of p53 inhibitor on survival and death of cells subjected to oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of caspase-3 in permanent and transient brain ischaemia in man

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Notch signaling: cell fate control and signal integration in development

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphoproteome and transcriptome analysis of the neuronal response to a CDK5 inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A role for p53 in maintaining and establishing the quiescence growth arrest in human cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recent evidence regarding a role for Cdk5 dysregulation in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NGF regulates the PC12 cell cycle machinery through specific inhibition of the Cdk kinases and induction of cyclin D1

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 inhibits hypoxia-inducible factor-stimulated transcription

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclin D1 provides a link between development and oncogenesis in the retina and breast.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Downregulation of CDC2 upon terminal differentiation of neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53-dependent cell death signaling in neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CDK inhibitors: positive and negative regulators of G1-phase progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Up-regulation of Bcl-2 homology 3 (BH3)-only proteins by E2F1 mediates apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 has a direct apoptogenic role at the mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53AIP1 regulates the mitochondrial apoptotic pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal Cdc2-like kinases: neuron-specific forms of Cdk5.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

From bench to clinic with apoptosis-based therapeutic agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes of p53 in the brains of patients with Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Roscovitine-induced up-regulation of p53AIP1 protein precedes the onset of apoptosis in human MCF-7 breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 Deficiency in liver reduces local control of survival and proliferation, but does not affect apoptosis after DNA damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurodegeneration in excitotoxicity, global cerebral ischemia, and target deprivation: A perspective on the contributions of apoptosis and necrosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of cell cycle elements, cyclin-dependent kinases, pRb, and E2F x DP, in B-amyloid-induced neuronal death

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A brain-specific activator of cyclin-dependent kinase 5.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clausine Z, a new carbazole alkaloid from Clausena excavata with inhibitory activity on CDK5.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA replication precedes neuronal cell death in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two new p73 splice variants, gamma and delta, with different transcriptional activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of p53-induced apoptosis in cerebral ischemia: effects of the p53 inhibitor pifithrin alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell death during development of the nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Major differences in Ca2+i response to anoxia between neonatal and adult rat CA1 neurons: role of Ca2+o and Na+o.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bax-dependent caspase-3 activation is a key determinant in p53-induced apoptosis in neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of the ataxia-telangiectasia gene product causes oxidative damage in target organs.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis and brain ischaemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wild-type but not Alzheimer-mutant amyloid precursor protein confers resistance against p53-mediated apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular oxygen sensing by mitochondria: old questions, new insight

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An anti-apoptotic role for the p53 family member, p73, during developmental neuron death

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contribution of p53-dependent caspase activation to neuronal cell death declines with neuronal maturation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adenovirus-mediated gene transfer of the tumor suppressor, p53, induces apoptosis in postmitotic neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential regulation of cellular target genes by p53 devoid of the PXXP motifs with impaired apoptotic activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal life and death: an essential role for the p53 family

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Excitotoxins in neuronal apoptosis and necrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation and cleavage of caspase-3 in apoptosis induced by experimental cerebral ischemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p73 is required for survival and maintenance of CNS neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of CPP-32 protease in hippocampal neurons following ischemia and epilepsy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of p53 tumor suppressor in ageing: regulation of transient cell cycle arrest and terminal senescence

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of apoptosis in HeLa cells by trans-activation-deficient p53.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular Abeta42 activates p53 promoter: a pathway to neurodegeneration in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel p53 inactivators with neuroprotective action: syntheses and pharmacological evaluation of 2-imino-2,3,4,5,6,7-hexahydrobenzothiazole and 2-imino-2,3,4,5,6,7-hexahydrobenzoxazole derivatives.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p73 is a simian [correction of human] p53-related protein that can induce apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial translocation of p53 and mitochondrial membrane potential (Delta Psi m) dissipation are early events in staurosporine-induced apoptosis of wild type and mutated p53 epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substrate specificity characterization of a cdc2-like protein kinase purified from bovine brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular diversity of glutamate receptors and implications for brain function

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reconstitution of neuronal Cdc2-like kinase from bacteria-expressed Cdk5 and an active fragment of the brain-specific activator. Kinase activation in the absence of Cdk5 phosphorylation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Butyrolactone I, a selective inhibitor of cdk2 and cdc2 kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal survival and p73/p63/p53: a family affair

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of CDK5 is protective in necrotic and apoptotic paradigms of neuronal cell death and prevents mitochondrial dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetic model of R-roscovitine and its metabolite in healthy male subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BH3-Only proteins-essential initiators of apoptotic cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The tumor suppressor p53.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis after experimental stroke: fact or fashion?

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis: implications of basic research for clinical oncology

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase-activated DNase/DNA fragmentation factor 40 mediates apoptotic DNA fragmentation in transient cerebral ischemia and in neuronal cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adenovirus-mediated p53AIP1 gene transfer as a new strategy for treatment of p53-resistant tumors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The therapeutic potential of poly(ADP-ribose) polymerase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The crystal structure of cyclin A

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that DeltaNp73 promotes neuronal survival by p53-dependent and p53-independent mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 family update: p73 and p63 develop their own identities

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship between metabolic dysfunctions, gene responses and delayed cell death after mild focal cerebral ischemia in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for p53-mediated modulation of neuronal viability.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of cyclins in neuronal differentiation of immortalized hippocampal cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-frequency developmental abnormalities in p53-deficient mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlates of p53- and Fas (CD95)-mediated apoptosis in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased apoptosis in the cingulate sulcus of newborn piglets following transient hypoxia-ischaemia is related to the degree of high energy phosphate depletion during the insult

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A system for characterizing cellular and molecular events in programmed neuronal cell death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of functional domains in the neuronal Cdk5 activator protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Additional complexity in p73: induction by mitogens in lymphoid cells and identification of two new splicing variants ε and ζ

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/17003520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1385/MN:34:1:27

1 reference

Europe PubMed Central

15 August 2017

Dimensions Publication ID

0 references

1 reference

Europe PubMed Central

15 August 2017

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