(Q39396274)

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Pharmacologic synergy between dual phosphoinositide-3-kinase and mammalian target of rapamycin inhibition and 5-fluorouracil in PIK3CA mutant gastric cancer cells.

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22336586%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

Pharmacologic synergy between dual phosphoinositide-3-kinase and mammalian target of rapamycin inhibition and 5-fluorouracil in PIK3CA mutant gastric cancer cells (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22336586%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

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7

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23 January 2020

author name string

Bhaskar Bhattacharya

1

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23 January 2020

Mohamed Akram

2

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23 January 2020

Indirikumar Balasubramanian

3

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23 January 2020

Kimberley K Y Tam

4

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23 January 2020

King X Koh

5

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23 January 2020

Mei Q Yee

6

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23 January 2020

publication date

1 January 2012

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23 January 2020

Cancer Biology and Therapy

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23 January 2020

13

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23 January 2020

1

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23 January 2020

34-42

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23 January 2020

Mechanisms of disease: PI3K/AKT signaling in gastrointestinal cancers

1 reference

https://api.crossref.org/works/10.4161%2FCBT.13.1.18437

21 January 2018

Gastric cancer in the era of molecularly targeted agents: current drug development strategies

1 reference

https://api.crossref.org/works/10.4161%2FCBT.13.1.18437

21 January 2018

The PI3K pathway as drug target in human cancer

1 reference

https://api.crossref.org/works/10.4161%2FCBT.13.1.18437

21 January 2018

Drugging the PI3 kinome: from chemical tools to drugs in the clinic.

1 reference

https://api.crossref.org/works/10.4161%2FCBT.13.1.18437

21 January 2018

5-Fluorouracil: mechanisms of action and clinical strategies

1 reference

https://api.crossref.org/works/10.4161%2FCBT.13.1.18437

21 January 2018

Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism

1 reference

https://api.crossref.org/works/10.4161%2FCBT.13.1.18437

21 January 2018

Live or let die: E2F1 and PI3K pathways intersect to make life or death decisions

1 reference

https://api.crossref.org/works/10.4161%2FCBT.13.1.18437

21 January 2018

A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling

1 reference

https://api.crossref.org/works/10.4161%2FCBT.13.1.18437

21 January 2018

Histone H2AX phosphorylation as a molecular pharmacological marker for DNA interstrand crosslink cancer chemotherapy.

1 reference

https://api.crossref.org/works/10.4161%2FCBT.13.1.18437

21 January 2018

Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases.

1 reference

https://api.crossref.org/works/10.4161%2FCBT.13.1.18437

21 January 2018

A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition.

1 reference

https://api.crossref.org/works/10.4161%2FCBT.13.1.18437

21 January 2018

Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism.

1 reference

https://api.crossref.org/works/10.4161%2FCBT.13.1.18437

21 January 2018

Targeting the PI3K-AKT-mTOR pathway: progress, pitfalls, and promises

1 reference

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21 January 2018

The pyridinylfuranopyrimidine inhibitor, PI-103, chemosensitizes glioblastoma cells for apoptosis by inhibiting DNA repair.

1 reference

https://api.crossref.org/works/10.4161%2FCBT.13.1.18437

21 January 2018

Class I PI3 kinase inhibition by the pyridinylfuranopyrimidine inhibitor PI-103 enhances tumor radiosensitivity.

1 reference

https://api.crossref.org/works/10.4161%2FCBT.13.1.18437

21 January 2018

Synergistic effect of mTOR inhibitor rapamycin and fluorouracil in inducing apoptosis and cell senescence in hepatocarcinoma cells

1 reference

https://api.crossref.org/works/10.4161%2FCBT.13.1.18437

21 January 2018

RAD001 shows activity against gastric cancer cells and overcomes 5-FU resistance by downregulating thymidylate synthase

1 reference

https://api.crossref.org/works/10.4161%2FCBT.13.1.18437

21 January 2018

Synergistic antiproliferative effect of mTOR inhibitors in combination with 5-fluorouracil in scirrhous gastric cancer

1 reference

https://api.crossref.org/works/10.4161%2FCBT.13.1.18437

21 January 2018

Human tumor mutants in the p110alpha subunit of PI3K.

1 reference

https://api.crossref.org/works/10.4161%2FCBT.13.1.18437

21 January 2018

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

1 reference

https://api.crossref.org/works/10.4161%2FCBT.13.1.18437

21 January 2018

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

1 reference

https://api.crossref.org/works/10.4161%2FCBT.13.1.18437

21 January 2018

Molecular pharmacology of phosphatidylinositol 3-kinase inhibition in human glioma

1 reference

https://api.crossref.org/works/10.4161%2FCBT.13.1.18437

21 January 2018

A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma

1 reference

https://api.crossref.org/works/10.4161%2FCBT.13.1.18437

21 January 2018

Low cytosine triphosphate synthase 2 expression renders resistance to 5-fluorouracil in colorectal cancer.

1 reference

https://api.crossref.org/works/10.4161%2FCBT.13.1.18437

21 January 2018

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

1 reference

https://api.crossref.org/works/10.4161%2FCBT.13.1.18437

21 January 2018

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