(Q39396823)

11 September 2017

Granzyme B-induced apoptosis requires both direct caspase activation and relief of caspase inhibition (English)

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11 September 2017

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Darren L Roberts

8

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Gabriela Constantinescu

object named as

Gabriela Constantinescu

5

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author name string

Ing Swie Goping

1

1 reference

11 September 2017

Michele Barry

2

1 reference

11 September 2017

Peter Liston

3

1 reference

11 September 2017

Tracy Sawchuk

4

1 reference

11 September 2017

Karolina M Michalak

6

1 reference

11 September 2017

Irene Shostak

7

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11 September 2017

Allison M Hunter

9

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11 September 2017

Robert Korneluk

10

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11 September 2017

R Chris Bleackley

11

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11 September 2017

language of work or name

English

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publication date

1 March 2003

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11 September 2017

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11 September 2017

18

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11 September 2017

355-365

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11 September 2017

3

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Granzyme B induces BID-mediated cytochrome c release and mitochondrial permeability transition

11 September 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

Cytotoxic T lymphocyte-assisted suicide. Caspase 3 activation is primarily the result of the direct action of granzyme B.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

Cytotoxic T lymphocytes: all roads lead to death

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

Granzyme B short-circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving Bid.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

Granzyme A loading induces rapid cytolysis and a novel form of DNA damage independently of caspase activation

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

Hsp27 negatively regulates cell death by interacting with cytochrome c.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

Electrostatic reversal of serine proteinase substrate specificity

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

Structural and biochemical basis of apoptotic activation by Smac/DIABLO

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

Structural basis of caspase-7 inhibition by XIAP

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

An apoptosis-inhibiting baculovirus gene with a zinc finger-like motif

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

Cleavage of CPP32 by granzyme B represents a critical role for granzyme B in the induction of target cell DNA fragmentation

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

X-linked IAP is a direct inhibitor of cell-death proteases

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

New Paradigm for Lymphocyte Granule-mediated Cytotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

Granzyme B-mediated cytochrome c release is regulated by the Bcl-2 family members bid and Bax.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

XIAP, the guardian angel

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

Intracellular K+ suppresses the activation of apoptosis in lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

Expression of inhibitor of apoptosis proteins (IAPs) in rat granulosa cells during ovarian follicular development and atresia

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

Endonuclease G is an apoptotic DNase when released from mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

Relief of extrinsic pathway inhibition by the Bid-dependent mitochondrial release of Smac in Fas-mediated hepatocyte apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

Identification of XAF1 as an antagonist of XIAP anti-Caspase activity

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

Mitochondria-dependent and -independent regulation of Granzyme B-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

Granzyme B-mediated apoptosis proceeds predominantly through a Bcl-2-inhibitable mitochondrial pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

Structural basis for the inhibition of caspase-3 by XIAP

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

Lymphocyte-mediated cytotoxicity.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

IAP proteins: blocking the road to death's door

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

Two CD95 (APO-1/Fas) signaling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

Direct cleavage of the human DNA fragmentation factor-45 by granzyme B induces caspase-activated DNase release and DNA fragmentation

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

Natural killer and lymphokine-activated killer cells require granzyme B for the rapid induction of apoptosis in susceptible target cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

Granzyme A initiates an alternative pathway for granule-mediated apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

Bcl-2 and Bcl-xL inhibit CD95-mediated apoptosis by preventing mitochondrial release of Smac/DIABLO and subsequent inactivation of X-linked inhibitor-of-apoptosis protein

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

Molecular characterization of mitochondrial apoptosis-inducing factor

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

Resistance to granzyme B-mediated cytochrome c release in Bak-deficient cells

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

Structural basis of IAP recognition by Smac/DIABLO

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

Elevation of neuronal expression of NAIP reduces ischemic damage in the rat hippocampus

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900032-3

7 January 2021

10.1016/S1074-7613(03)00032-3

Identifiers

DOI

1 reference

11 September 2017

1 reference