(Q39404321)

11 September 2017

Metabolic flux rearrangement in the amino acid metabolism reduces ammonia stress in the α1-antitrypsin producing human AGE1.HN cell line (English)

1 reference

11 September 2017

5

Elmar Heinzle

1 reference

11 September 2017

Christian Priesnitz

1

1 reference

11 September 2017

Jens Niklas

series ordinal

2

1 reference

11 September 2017

Thomas Rose

series ordinal

3

1 reference

11 September 2017

Volker Sandig

series ordinal

4

1 reference

11 September 2017

25 January 2012

1 reference

11 September 2017

Metabolic Engineering

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11 September 2017

14

1 reference

11 September 2017

2

1 reference

11 September 2017

128-137

1 reference

Metabolic flux analysis of CHO cells at growth and non-growth phases using isotopic tracers and mass spectrometry

11 September 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

The effect of ammonia on the O-linked glycosylation of granulocyte colony-stimulating factor produced by chinese hamster ovary cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Genetic engineering of hybridoma glutamine metabolism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

N-glycosylation and biological activity of recombinant human alpha1-antitrypsin expressed in a novel human neuronal cell line

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Metabolic flux analysis and pharmaceutical production

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Activity of glutamate dehydrogenase is increased in ammonia-stressed hybridoma cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Metabolic-flux analysis of continuously cultured hybridoma cells using (13)CO(2) mass spectrometry in combination with (13)C-lactate nuclear magnetic resonance spectroscopy and metabolite balancing

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Ammonia affects the glycosylation patterns of recombinant mouse placental lactogen-I by chinese hamster ovary cells in a pH-dependent manner.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

L-arginine uptake, the citrulline-NO cycle and arginase II in the rat brain: an in situ hybridization study.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Structure and variation of human alpha 1-antitrypsin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Effects of elevated ammonium on glycosylation gene expression in CHO cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Ammonia removal using hepatoma cells in mammalian cell cultures

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Metabolomics for high-resolution monitoring of the cellular physiological state in cell culture engineering.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Determination of urea using high-performance liquid chromatography with fluorescence detection after automated derivatisation with xanthydrol

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

High level expression of tissue inhibitor of metalloproteinases in Chinese hamster ovary cells using glutamine synthetase gene amplification

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Effects of ammonia and lactate on growth, metabolism, and productivity of BHK cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

On-line gas analysis in animal cell cultivation: II. Methods for oxygen uptake rate estimation and its application to controlled feeding of glutamine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Reduction of waste product excretion via nutrient control: Possible strategies for maximizing product and cell yields on serum in cultures of mammalian cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Chromosomal localization of the human arginase II gene and tissue distribution of its mRNA

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Influence of ammonium on growth, metabolism, and productivity of a continuous suspension Chinese hamster ovary cell culture

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Enhanced glycoprotein production in HEK-293 cells expressing pyruvate carboxylase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Elucidation of cellular metabolism via metabolomics and stable-isotope assisted metabolomics

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Substitution of glutamine by glutamate enhances production and galactosylation of recombinant IgG in Chinese hamster ovary cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Recombinant human alpha-1 proteinase inhibitor: towards therapeutic use.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Metabolic characterization of a hyper-productive state in an antibody producing NS0 myeloma cell line

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Comprehensive glyco-proteomic analysis of human alpha1-antitrypsin and its charge isoforms

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

The effect of ammonium chloride on the multiplication of herpes simplex virus type 1 in Vero cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

In vivo quantification of intracellular amino acids and intermediates of the methionine pathway in Corynebacterium glutamicum

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Growth behavior of Chinese hamster ovary cells in a compact loop bioreactor. 2. Effects of medium components and waste products

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Profiling of dynamic changes in hypermetabolic livers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Engineering mammalian cells in bioprocessing - current achievements and future perspectives

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Quantification of statin effects on hepatic cholesterol synthesis by transient (13)C-flux analysis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Effect of ammonium ion and extracellular pH on hybridoma cell metabolism and antibody production

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Transient responses of hybridoma cells to lactate and ammonia pulse and step changes in continuous culture

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Ammonium toxicity in different cell lines

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Human 293 cell metabolism in low glutamine-supplied culture: interpretation of metabolic changes through metabolic flux analysis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Effects of drugs in subtoxic concentrations on the metabolic fluxes in human hepatoma cell line Hep G2.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Quercetin treatment changes fluxes in the primary metabolism and increases culture longevity and recombinant α₁-antitrypsin production in human AGE1.HN cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Metabolite channeling and compartmentation in the human cell line AGE1.HN determined by 13C labeling experiments and 13C metabolic flux analysis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Metabolic flux analysis in eukaryotes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Quantitative characterization of metabolism and metabolic shifts during growth of the new human cell line AGE1.HN using time resolved metabolic flux analysis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

An integrated approach to improved toxicity prediction for the safety assessment during preclinical drug development using Hep G2 cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Effects of ammonia and lactate on hybridoma growth, metabolism, and antibody production

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Expression of carbamoyl phosphate synthetase I and ornithine transcarbamoylase genes in Chinese hamster ovary dhfr-cells decreases accumulation of ammonium ion in culture media

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Metabolic flux analysis in mammalian cell culture

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Factors affecting cell growth and monoclonal antibody production in stirred reactors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Biochemistry of growth inhibition by ammonium ions in mammalian cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

The importance of ammonia in mammalian cell culture

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Growth study of lactate and ammonia double-resistant clones of HL-60 cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Influence of different ammonium, lactate and glutamine concentrations on CCO cell growth

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Metabolic fluxes and metabolic engineering

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Metabolic flux analysis gives an insight on verapamil induced changes in central metabolism of HL-1 cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Chloroquine and ammonium chloride prevent terminal glycosylation of immunoglobulins in plasma cells without affecting secretion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Augmentation therapy in alpha-1 antitrypsin deficiency: advances and controversies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Spontaneous decomposition of glutamine in cell culture media

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Linear constraint relations in biochemical reaction systems: II. Diagnosis and estimation of gross errors.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Biopharmaceutical benchmarks 2006.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Biopharmaceutical benchmarks 2010

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Production of recombinant protein therapeutics in cultivated mammalian cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Applications of improved stoichiometric model in medium design and fed-batch cultivation of animal cells in bioreactor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Effects of ammonia on CHO cell growth, erythropoietin production, and glycosylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Effects of ammonia and glucosamine on the heterogeneity of erythropoietin glycoforms.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

A functional analysis of N-glycosylation-related genes on sialylation of recombinant erythropoietin in six commonly used mammalian cell lines.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

Intracellular flux analysis in hybridomas using mass balances and in vitro (13)C nmr.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.01.001

10.1016/J.YMBEN.2012.01.001

7 January 2021

Identifiers

DOI

1 reference

11 September 2017

1 reference