(Q39406788)

11 September 2017

title

Inhibition of GPR40 protects MIN6 β cells from palmitate-induced ER stress and apoptosis (English)

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11 September 2017

Jinwei Wu

1

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11 September 2017

Peng Sun

2

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11 September 2017

Xiaodong Zhang

3

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11 September 2017

Hong Liu

4

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11 September 2017

Hualiang Jiang

5

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11 September 2017

Weiliang Zhu

6

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11 September 2017

Heyao Wang

7

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11 September 2017

publication date

1 April 2012

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Journal of Cellular Biochemistry

11 September 2017

published in

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11 September 2017

volume

113

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11 September 2017

issue

4

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11 September 2017

page(s)

1152-1158

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Palmitate-induced beta-cell dysfunction is associated with excessive NO production and is reversed by thiazolidinedione-mediated inhibition of GPR40 transduction mechanisms

11 September 2017

cites work

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Rosiglitazone counteracts palmitate-induced beta-cell dysfunction by suppression of MAP kinase, inducible nitric oxide synthase and caspase 3 activities

21 January 2018

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Cytokine-induced beta-cell death is independent of endoplasmic reticulum stress signaling.

21 January 2018

1 reference

The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids

21 January 2018

1 reference

Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules

21 January 2018

1 reference

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

21 January 2018

1 reference

Increased beta-cell apoptosis prevents adaptive increase in beta-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid

21 January 2018

1 reference

Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation.

21 January 2018

1 reference

Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities

21 January 2018

1 reference

Causes and cures for endoplasmic reticulum stress in lipotoxic β-cell dysfunction

21 January 2018

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Initiation and execution of lipotoxic ER stress in pancreatic beta-cells

21 January 2018

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Differential regulation of the ER stress response by long-chain fatty acids in the pancreatic beta-cell

21 January 2018

1 reference

Decreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implications

21 January 2018

1 reference

Lipid-induced pancreatic β-cell dysfunction: focus on in vivo studies

21 January 2018

1 reference

Effects of palmitate on ER and cytosolic Ca2+ homeostasis in beta-cells

21 January 2018

1 reference

Endoplasmic reticulum stress and the development of diabetes: a review

21 January 2018

1 reference

Transcriptional and translational control in the Mammalian unfolded protein response

21 January 2018

1 reference

A novel class of antagonists for the FFAs receptor GPR40.

21 January 2018

1 reference

The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes

21 January 2018

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Mechanisms linking obesity to insulin resistance and type 2 diabetes

21 January 2018

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Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis

21 January 2018

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Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

21 January 2018

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Death effectors of beta-cell apoptosis in type 1 diabetes

21 January 2018

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Calcium-independent phospholipase A2 (iPLA2 beta)-mediated ceramide generation plays a key role in the cross-talk between the endoplasmic reticulum (ER) and mitochondria during ER stress-induced insulin-secreting cell apoptosis

21 January 2018

1 reference

Beta-cell apoptosis in type 2 diabetes: quantitative and functional consequences.

21 January 2018

1 reference

Inhibition of Foxo1 protects pancreatic islet beta-cells against fatty acid and endoplasmic reticulum stress-induced apoptosis

21 January 2018

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Roles of CHOP/GADD153 in endoplasmic reticulum stress

21 January 2018

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Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes

21 January 2018

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Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress

21 January 2018

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Free fatty acids increase cytosolic free calcium and stimulate insulin secretion from beta-cells through activation of GPR40.

21 January 2018

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Endoplasmic reticulum stress responses

21 January 2018

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Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes

21 January 2018

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The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse

21 January 2018

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Beta cell apoptosis in diabetes

21 January 2018

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Diabetes as a disease of endoplasmic reticulum stress

21 January 2018

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Fatty acid-induced oxidation and triglyceride formation is higher in insulin-producing MIN6 cells exposed to oleate compared to palmitate

21 January 2018

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TAK-875, an orally available G protein-coupled receptor 40/free fatty acid receptor 1 agonist, enhances glucose-dependent insulin secretion and improves both postprandial and fasting hyperglycemia in type 2 diabetic rats

21 January 2018

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Endoplasmic reticulum stress-induced apoptosis in the development of diabetes: is there a role for adipose tissue and liver?

21 January 2018

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IL-1beta caused pancreatic beta-cells apoptosis is mediated in part by endoplasmic reticulum stress via the induction of endoplasmic reticulum Ca2+ release through the c-Jun N-terminal kinase pathway

21 January 2018

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Sulfonylureas uncouple glucose-dependence for GPR40-mediated enhancement of insulin secretion from INS-1E cells

21 January 2018

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DC260126, a small-molecule antagonist of GPR40, improves insulin tolerance but not glucose tolerance in obese Zucker rats

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JCB.23450

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11 September 2017

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