(Q37797970)

23 August 2017

Diabetes as a disease of endoplasmic reticulum stress (English)

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23 August 2017

endoplasmic reticulum

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Stefan J Marciniak

5

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author name string

Sally E Thomas

1

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23 August 2017

Lucy E Dalton

2

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23 August 2017

Marie-Louise Daly

3

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23 August 2017

Elke Malzer

4

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23 August 2017

3 October 2010

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Diabetes - Metabolism: Research and Reviews

23 August 2017

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23 August 2017

26

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23 August 2017

8

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23 August 2017

611-621

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The first and fourth upstream open reading frames in GCN4 mRNA have similar initiation efficiencies but respond differently in translational control to change in length and sequence

23 August 2017

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Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153).

21 January 2018

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Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes

21 January 2018

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Leukemic HRX fusion proteins inhibit GADD34-induced apoptosis and associate with the GADD34 and hSNF5/INI1 proteins

21 January 2018

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Evidence for the interaction between Translin and GADD34 in mammalian cells

21 January 2018

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Involvement of endoplasmic reticulum stress in insulin resistance and diabetes

21 January 2018

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Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

21 January 2018

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PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance

21 January 2018

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Endoplasmic reticulum stress signaling in disease

21 January 2018

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7 January 2021

Ero1p: a novel and ubiquitous protein with an essential role in oxidative protein folding in the endoplasmic reticulum

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7 January 2021

The ERO1 gene of yeast is required for oxidation of protein dithiols in the endoplasmic reticulum

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7 January 2021

ERO1-L, a human protein that favors disulfide bond formation in the endoplasmic reticulum

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7 January 2021

Endoplasmic reticulum oxidoreductin 1-lbeta (ERO1-Lbeta), a human gene induced in the course of the unfolded protein response

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7 January 2021

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

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7 January 2021

Tissue-specific expression and dimerization of the endoplasmic reticulum oxidoreductase Ero1beta

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7 January 2021

Manipulation of oxidative protein folding and PDI redox state in mammalian cells

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7 January 2021

Coordinated nonvectorial folding in a newly synthesized multidomain protein

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7 January 2021

Degradation of misfolded proteins prevents ER-derived oxidative stress and cell death

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7 January 2021

The protective and destructive roles played by molecular chaperones during ERAD (endoplasmic-reticulum-associated degradation).

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7 January 2021

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

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7 January 2021

Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress

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7 January 2021

Perk is essential for translational regulation and cell survival during the unfolded protein response

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7 January 2021

Transcriptional and translational control in the Mammalian unfolded protein response

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7 January 2021

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

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7 January 2021

Infancy-onset diabetes mellitus and multiple epiphyseal dysplasia

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7 January 2021

EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome

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7 January 2021

Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

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7 January 2021

Proinsulin disulfide maturation and misfolding in the endoplasmic reticulum

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7 January 2021

PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis.

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7 January 2021

Structure and intermolecular interactions of the luminal dimerization domain of human IRE1alpha

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7 January 2021

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

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7 January 2021

Modulation of the eukaryotic initiation factor 2 alpha-subunit kinase PERK by tyrosine phosphorylation

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7 January 2021

Activation-dependent substrate recruitment by the eukaryotic translation initiation factor 2 kinase PERK.

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7 January 2021

Translational control is required for the unfolded protein response and in vivo glucose homeostasis

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7 January 2021

Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis

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7 January 2021

Inhibition of a constitutive translation initiation factor 2alpha phosphatase, CReP, promotes survival of stressed cells

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7 January 2021

Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha

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7 January 2021

Stress-induced gene expression requires programmed recovery from translational repression

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7 January 2021

Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response

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7 January 2021

Coupling of GCN4 mRNA translational activation with decreased rates of polypeptide chain initiation

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7 January 2021

Gene-specific translational control of the yeast GCN4 gene by phosphorylation of eukaryotic initiation factor 2.

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7 January 2021

Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells

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7 January 2021

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

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7 January 2021

Amino acid limitation regulates CHOP expression through a specific pathway independent of the unfolded protein response.

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7 January 2021

Compensatory responses in mice carrying a null mutation for Ins1 or Ins2.

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7 January 2021

A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse

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7 January 2021

Dominant negative pathogenesis by mutant proinsulin in the Akita diabetic mouse

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7 January 2021

The endoplasmic reticulum stress response is stimulated through the continuous activation of transcription factors ATF6 and XBP1 in Ins2+/Akita pancreatic beta cells.

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7 January 2021

High ER stress in beta-cells stimulates intracellular degradation of misfolded insulin

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7 January 2021

Proinsulin maturation, misfolding, and proteotoxicity

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7 January 2021

Insulin gene mutations as a cause of permanent neonatal diabetes

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7 January 2021

Dominant-Negative Effects of a Novel Mutated Ins2 Allele Causes Early-Onset Diabetes and Severe -Cell Loss in Munich Ins2C95S Mutant Mice

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7 January 2021

Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway

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7 January 2021

A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress

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7 January 2021

Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis

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7 January 2021

Interaction between DNA-damage protein GADD34 and a new member of the Hsp40 family of heat shock proteins that is induced by a DNA-damaging reagent

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7 January 2021

Interaction between GADD34 and kinesin superfamily, KIF3A

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7 January 2021

Interaction between growth arrest-DNA damage protein 34 and Src kinase Lyn negatively regulates genotoxic apoptosis

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7 January 2021

The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity

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7 January 2021

Human BAG-1 Proteins Bind to the Cellular Stress Response Protein GADD34 and Interfere with GADD34 Functions

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7 January 2021

GADD34-PP1c recruited by Smad7 dephosphorylates TGFbeta type I receptor

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7 January 2021

Glucose activates a protein phosphatase-1-mediated signaling pathway to enhance overall translation in pancreatic beta-cells.

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7 January 2021

The biology of incretin hormones

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7 January 2021

Glucagon-like peptide-1 and the islet beta-cell: augmentation of cell proliferation and inhibition of apoptosis

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7 January 2021

Development and characterization of a glucagon-like peptide 1-albumin conjugate: the ability to activate the glucagon-like peptide 1 receptor in vivo

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7 January 2021

Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis

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7 January 2021

GLP-1 receptor activation improves beta cell function and survival following induction of endoplasmic reticulum stress

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7 January 2021

Protection of pancreatic beta-cells by exendin-4 may involve the reduction of endoplasmic reticulum stress; in vivo and in vitro studies

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7 January 2021

Regulation of cap-dependent translation by eIF4E inhibitory proteins

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7 January 2021

ATF4-mediated induction of 4E-BP1 contributes to pancreatic beta cell survival under endoplasmic reticulum stress

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7 January 2021

Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes

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7 January 2021

Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells

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7 January 2021

Antioxidant enzyme activity and mRNA expression in the islets of Langerhans from the BB/S rat model of type 1 diabetes and an insulin-producing cell line

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7 January 2021

Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues.

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7 January 2021

Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants

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7 January 2021

A role for glutathione peroxidase in protecting pancreatic beta cells against oxidative stress in a model of glucose toxicity

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7 January 2021

Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity

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7 January 2021

Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase

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7 January 2021

Dissociation of Kar2p/BiP from an ER sensory molecule, Ire1p, triggers the unfolded protein response in yeast

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7 January 2021

Genetic evidence for a role of BiP/Kar2 that regulates Ire1 in response to accumulation of unfolded proteins.

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7 January 2021

Structure of the Dual Enzyme Ire1 Reveals the Basis for Catalysis and Regulation in Nonconventional RNA Splicing

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7 January 2021

Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development

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7 January 2021

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

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7 January 2021

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

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7 January 2021

IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response

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7 January 2021

A time-dependent phase shift in the mammalian unfolded protein response

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7 January 2021

XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

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7 January 2021

XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands

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7 January 2021

XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation

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7 January 2021

XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum.

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7 January 2021

The X-box binding protein-1 transcription factor is required for plasma cell differentiation and the unfolded protein response

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7 January 2021

Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1

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7 January 2021

Plasma cell differentiation requires the transcription factor XBP-1

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7 January 2021

Bypassing a Kinase Activity with an ATP-Competitive Drug

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7 January 2021

A kinase inhibitor activates the IRE1alpha RNase to confer cytoprotection against ER stress

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7 January 2021

IRE1 signaling affects cell fate during the unfolded protein response

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7 January 2021

Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1.

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7 January 2021

Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response.

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7 January 2021

Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress

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7 January 2021

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

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7 January 2021

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

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7 January 2021

ASK1 is essential for JNK/SAPK activation by TRAF2

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7 January 2021

Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways

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7 January 2021

Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.

1 reference

7 January 2021

Execution of Apoptosis Signal-regulating Kinase 1 (ASK1)-induced Apoptosis by the Mitochondria-dependent Caspase Activation

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7 January 2021

Human caspase 12 has acquired deleterious mutations

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7 January 2021

Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress

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7 January 2021

AIP1 is critical in transducing IRE1-mediated endoplasmic reticulum stress response

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7 January 2021

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

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7 January 2021

Inhibition of nuclear factor-kappaB or Bax prevents endoplasmic reticulum stress- but not nitric oxide-mediated apoptosis in INS-1E cells

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7 January 2021

Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha

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7 January 2021

Tissue-specific roles of IRS proteins in insulin signaling and glucose transport

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7 January 2021

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

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7 January 2021

The endoplasmic reticulum chaperone improves insulin resistance in type 2 diabetes.

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7 January 2021

Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes

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7 January 2021

Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease

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7 January 2021

Tumor necrosis factor alpha (TNFalpha) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS)-dependent fashion, and the UPR counteracts ROS accumulation by TNFalpha

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7 January 2021

Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells

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7 January 2021

Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death

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7 January 2021

Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress

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7 January 2021

Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

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7 January 2021

Saturated fatty acid-mediated endoplasmic reticulum stress and apoptosis are augmented by trans-10, cis-12-conjugated linoleic acid in liver cells

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7 January 2021

Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis

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7 January 2021

Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis

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7 January 2021

Palmitate modulates intracellular signaling, induces endoplasmic reticulum stress, and causes apoptosis in mouse 3T3-L1 and rat primary preadipocytes

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7 January 2021

Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells

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7 January 2021

Adverse physicochemical properties of tripalmitin in beta cells lead to morphological changes and lipotoxicity in vitro

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7 January 2021

Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death

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7 January 2021

Reduced endoplasmic reticulum (ER)-to-Golgi protein trafficking contributes to ER stress in lipotoxic mouse beta cells by promoting protein overload.

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7 January 2021

Effects of palmitate on ER and cytosolic Ca2+ homeostasis in beta-cells

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7 January 2021

Initiation and execution of lipotoxic ER stress in pancreatic beta-cells

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7 January 2021

Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

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7 January 2021

Molecular design and biological activities of protein-tyrosine phosphatase inhibitors

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7 January 2021

Cellular effects of small molecule PTP1B inhibitors on insulin signaling

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7 January 2021

Protein-tyrosine phosphatase 1B potentiates IRE1 signaling during endoplasmic reticulum stress

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7 January 2021

The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance

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7 January 2021

Overexpression of protein-tyrosine phosphatase-1B in adipocytes inhibits insulin-stimulated phosphoinositide 3-kinase activity without altering glucose transport or Akt/Protein kinase B activation

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7 January 2021

ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1

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7 January 2021

The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi

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7 January 2021

ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals

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7 January 2021

ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

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7 January 2021

Luman, the cellular counterpart of herpes simplex virus VP16, is processed by regulated intramembrane proteolysis

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7 January 2021

Potential role for luman, the cellular homologue of herpes simplex virus VP16 (alpha gene trans-inducing factor), in herpesvirus latency

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7 January 2021

Luman is capable of binding and activating transcription from the unfolded protein response element

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7 January 2021

OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes

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7 January 2021

Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response

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7 January 2021

CREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P.

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7 January 2021

A feat of metabolic proportions: Pdx1 orchestrates islet development and function in the maintenance of glucose homeostasis

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7 January 2021

Early-onset type-II diabetes mellitus (MODY4) linked to IPF1

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7 January 2021

Reduced PDX-1 expression impairs islet response to insulin resistance and worsens glucose homeostasis

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7 January 2021

Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress

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7 January 2021

The pancreatic ductal epithelium serves as a potential pool of progenitor cells

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7 January 2021

beta-cell neogenesis during prolonged hyperglycemia in rats

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7 January 2021

Lineage tracing and characterization of insulin-secreting cells generated from adult pancreatic acinar cells

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7 January 2021

Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes

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7 January 2021

Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation

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7 January 2021

Recovery from diabetes in mice by beta cell regeneration

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7 January 2021

Direct evidence of attempted beta cell regeneration in an 89-year-old patient with recent-onset type 1 diabetes

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7 January 2021

ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth

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7 January 2021

PERK regulates the proliferation and development of insulin-secreting beta-cell tumors in the endocrine pancreas of mice

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7 January 2021

Hypoxia-induced energy stress regulates mRNA translation and cell growth

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7 January 2021

Mammalian unfolded protein response inhibits cyclin D1 translation and cell-cycle progression

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7 January 2021

PERK mediates cell-cycle exit during the mammalian unfolded protein response

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7 January 2021

PKR and PKR-like endoplasmic reticulum kinase induce the proteasome-dependent degradation of cyclin D1 via a mechanism requiring eukaryotic initiation factor 2alpha phosphorylation

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7 January 2021

Ribosomal stress couples the unfolded protein response to p53-dependent cell cycle arrest

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7 January 2021

Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta

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7 January 2021

Endoplasmic reticulum stress accelerates p53 degradation by the cooperative actions of Hdm2 and glycogen synthase kinase 3beta

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7 January 2021

Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53

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7 January 2021

The eIF2alpha kinases PERK and PKR activate glycogen synthase kinase 3 to promote the proteasomal degradation of p53.

1 reference

7 January 2021

Regulation of HDM2 activity by the ribosomal protein L11

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7 January 2021

Ribosomal Protein L11 Negatively Regulates Oncoprotein MDM2 and Mediates a p53-Dependent Ribosomal-Stress Checkpoint Pathway

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7 January 2021

Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5

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7 January 2021

Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition

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7 January 2021

Inhibition of HDM2 and activation of p53 by ribosomal protein L23

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7 January 2021

Phosphorylation of eukaryotic translation initiation factor 2alpha coordinates rRNA transcription and translation inhibition during endoplasmic reticulum stress

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7 January 2021

Identifiers

DOI

10.1002/DMRR.1132

1 reference

23 August 2017

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