(Q40085524)

17 September 2017

The eIF2alpha kinases PERK and PKR activate glycogen synthase kinase 3 to promote the proteasomal degradation of p53. (English)

1 reference

17 September 2017

Dionissios Baltzis

1

1 reference

17 September 2017

Olivier Pluquet

2

1 reference

17 September 2017

Andreas I Papadakis

3

1 reference

17 September 2017

Shirin Kazemi

4

1 reference

17 September 2017

Li-Ke Qu

5

1 reference

17 September 2017

Antonis E Koromilas

6

1 reference

17 September 2017

language of work or name

English

0 references

publication date

4 September 2007

1 reference

Journal of Biological Chemistry

17 September 2017

1 reference

17 September 2017

282

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17 September 2017

31675-31687

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17 September 2017

43

1 reference

Live or let die: the cell's response to p53

17 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

p53: traffic cop at the crossroads of DNA repair and recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

The role of p53 in determining sensitivity to radiotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

The p53 pathway: positive and negative feedback loops

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

Post-translational modification of p53 in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

Inhibiting the p53-MDM2 interaction: an important target for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

The ubiquitin ligase COP1 is a critical negative regulator of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

The p53 paddy wagon: COP1, Pirh2 and MDM2 are found resisting apoptosis and growth arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

The importance of p53 location: nuclear or cytoplasmic zip code?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

Small molecules that reactivate mutant p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

Does the ribosome translate cancer?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

Translational control in stress and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

Translational control in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

Molecular mechanisms of translational control

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

Gene-specific regulation by general translation factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

The double-stranded RNA-dependent protein kinase PKR: structure and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

The mammalian unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

The role of the unfolded protein response in tumour development: friend or foe?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

Endoplasmic reticulum stress accelerates p53 degradation by the cooperative actions of Hdm2 and glycogen synthase kinase 3beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

Glycogen synthase kinase 3-dependent phosphorylation of Mdm2 regulates p53 abundance

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

Initiation of Protein Synthesis by Hepatitis C Virus Is Refractory to Reduced eIF2 · GTP · Met-tRNAiMet Ternary Complex Availability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

Control of alpha subunit of eukaryotic translation initiation factor 2 (eIF2 alpha) phosphorylation by the human papillomavirus type 18 E6 oncoprotein: implications for eIF2 alpha-dependent gene expression and cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

The dsRNA binding protein family: critical roles, diverse cellular functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

Heterologous dimerization domains functionally substitute for the double-stranded RNA binding domains of the kinase PKR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

Linking mRNA turnover and translation: assessing the polyribosomal association of mRNA decay factors and degradative intermediates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

Regulated translation initiation controls stress-induced gene expression in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

Getting oncolytic virus therapies off the ground

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

Translational control is required for the unfolded protein response and in vivo glucose homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

GSK3 inhibitors: development and therapeutic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

Oncolytic viruses and cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

Protein synthesis required to anchor a mutant p53 protein which is temperature-sensitive for nuclear transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

Akt enhances Mdm2-mediated ubiquitination and degradation of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

A novel function of eIF2alpha kinases as inducers of the phosphoinositide-3 kinase signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

Activation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

Frat is dispensable for canonical Wnt signaling in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

The regulation of glycogen synthase kinase-3 nuclear export by Frat/GBP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

Ribosomal stress couples the unfolded protein response to p53-dependent cell cycle arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

Role of Noxa in p53-independent fenretinide-induced apoptosis of neuroectodermal tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

The role of p53 in hypoxia-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

Hypoxia attenuates the p53 response to cellular damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

p53 cannot be induced by hypoxia alone but responds to the hypoxic microenvironment

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

Hypoxia activates glycogen synthase kinase-3 in mouse brain in vivo: protection by mood stabilizers and imipramine

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

Priming-dependent phosphorylation and regulation of the tumor suppressor pVHL by glycogen synthase kinase 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

Double-stranded-RNA-activated protein kinase PKR enhances transcriptional activation by tumor suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

Activation of GCN2 in UV-irradiated cells inhibits translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

The identification of an internal ribosomal entry site in the 5'-untranslated region of p53 mRNA provides a novel mechanism for the regulation of its translation following DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

Internal ribosome entry sites in cellular mRNAs: mystery of their existence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

Integration of interferon-alpha/beta signalling to p53 responses in tumour suppression and antiviral defence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

Resistance to viral infection of super p53 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

21 January 2018

Viruses and Apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

Down-regulation of p53 by double-stranded RNA modulates the antiviral response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

Cross talk between PML and p53 during poliovirus infection: implications for antiviral defense

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704491200

21 January 2018

Identifiers

DOI

10.1074/JBC.M704491200

1 reference

17 September 2017

1 reference