(Q44859686)

6 December 2017

title

p53 cannot be induced by hypoxia alone but responds to the hypoxic microenvironment (English)

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6 December 2017

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Yi Pan

1

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6 December 2017

Patricia R Oprysko

2

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6 December 2017

Andrew M Asham

3

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6 December 2017

Cameron J Koch

4

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6 December 2017

Marie Celeste Simon

5

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6 December 2017

language of work or name

English

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publication date

1 June 2004

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6 December 2017

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6 December 2017

volume

23

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6 December 2017

issue

29

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6 December 2017

page(s)

4975-4983

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p53 checkpoint-defective cells are sensitive to X rays, but not hypoxia

6 December 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

Activation of hypoxia-inducible factor 1alpha: posttranscriptional regulation and conformational change by recruitment of the Arnt transcription factor

21 January 2018

1 reference

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Targeted mutation of the murine arylhydrocarbon receptor nuclear translocator 2 (Arnt2) gene reveals partial redundancy with Arnt

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3alpha locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

The role of ARNT2 in tumor angiogenesis and the neural response to hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

Absolute requirement of aryl hydrocarbon receptor nuclear translocator protein for gene activation by hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

Mechanisms of hypoxia-induced endothelial cell death. Role of p53 in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

Purification and characterization of hypoxia-inducible factor 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

PUMA mediates the apoptotic response to p53 in colorectal cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

p38 Mitogen-activated protein kinase mediates hypoxic regulation of Mdm2 and p53 in neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

Hypoxia attenuates the p53 response to cellular damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

7 January 2021

Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

7 January 2021

Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

7 January 2021

A conserved family of prolyl-4-hydroxylases that modify HIF

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

7 January 2021

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

7 January 2021

Oncogenic alterations of metabolism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

7 January 2021

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

7 January 2021

Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

7 January 2021

Hypoxia inhibits G1/S transition through regulation of p27 expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

7 January 2021

The complexity of p53 modulation: emerging patterns from divergent signals

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

7 January 2021

Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

7 January 2021

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

7 January 2021

Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

7 January 2021

Hypoxia links ATR and p53 through replication arrest

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

7 January 2021

Mdm2 promotes the rapid degradation of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

7 January 2021

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

7 January 2021

Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

7 January 2021

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

7 January 2021

Expression of ARNT, ARNT2, HIF1 alpha, HIF2 alpha and Ah receptor mRNAs in the developing mouse.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

7 January 2021

Measurement of absolute oxygen levels in cells and tissues using oxygen sensors and 2-nitroimidazole EF5.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

7 January 2021

Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

7 January 2021

Regulation of p53 stability by Mdm2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

7 January 2021

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

7 January 2021

Unmasking of phosphorylation-sensitive epitopes on p53 and Mdm2 by a simple Western-phosphatase procedure

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

7 January 2021

Genotoxic and non-genotoxic pathways of p53 induction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

7 January 2021

Signaling to p53: breaking the MDM2-p53 circuit

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

7 January 2021

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

7 January 2021

Regulation of proliferation-survival decisions during tumor cell hypoxia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

7 January 2021

Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

7 January 2021

HIF-1: mediator of physiological and pathophysiological responses to hypoxia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

7 January 2021

Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

7 January 2021

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

7 January 2021

p53: good cop/bad cop.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

7 January 2021

The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

1 reference

7 January 2021

The p53-mdm-2 autoregulatory feedback loop

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

7 January 2021

A functional p53-responsive intronic promoter is contained within the humanmdm2gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1207657

1 reference

6 December 2017

1 reference