(Q39412554)

English

Transforming growth factor-beta1 (TGFbeta1) stimulates connective tissue growth factor (CCN2/CTGF) expression in human gingival fibroblasts through a RhoA-independent, Rac1/Cdc42-dependent mechanism: statins with forskolin block TGFbeta1-induced CCN

scientific article published on 20 February 2008

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

11 September 2017

Transforming growth factor-beta1 (TGFbeta1) stimulates connective tissue growth factor (CCN2/CTGF) expression in human gingival fibroblasts through a RhoA-independent, Rac1/Cdc42-dependent mechanism: statins with forskolin block TGFbeta1-induced CCN (English)

1 reference

Europe PubMed Central

PMC publication ID

11 September 2017

connective tissue

1 reference

based on heuristic

inferred from title

Philip C. Trackman

object named as

Philip C Trackman

2

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author name string

Samuel A Black

1

1 reference

Europe PubMed Central

PMC publication ID

11 September 2017

language of work or name

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publication date

20 February 2008

1 reference

Europe PubMed Central

PMC publication ID

11 September 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PMC publication ID

11 September 2017

283

1 reference

Europe PubMed Central

PMC publication ID

11 September 2017

16

1 reference

Europe PubMed Central

PMC publication ID

11 September 2017

10835-10847

1 reference

Europe PubMed Central

PMC publication ID

11 September 2017

Tissue-specific mechanisms for CCN2/CTGF persistence in fibrotic gingiva: interactions between cAMP and MAPK signaling pathways, and prostaglandin E2-EP3 receptor mediated activation of the c-JUN N-terminal kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

11 September 2017

Targeted disruption of TGF-beta/Smad3 signaling modulates skin fibrosis in a mouse model of scleroderma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

11 September 2017

Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

11 September 2017

The CCN family: a new stimulus package

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

11 September 2017

The statins as anticancer agents

1 reference

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11 September 2017

The specificities of protein kinase inhibitors: an update

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

11 September 2017

Gene regulation of connective tissue growth factor: new targets for antifibrotic therapy?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

11 September 2017

Identification of integrin alpha(M)beta(2) as an adhesion receptor on peripheral blood monocytes for Cyr61 (CCN1) and connective tissue growth factor (CCN2): immediate-early gene products expressed in atherosclerotic lesions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

11 September 2017

HMG-CoA reductase inhibitors and the malignant cell: the statin family of drugs as triggers of tumor-specific apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

11 September 2017

Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

11 September 2017

Rho-dependent inhibition of the induction of connective tissue growth factor (CTGF) by HMG CoA reductase inhibitors (statins)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

11 September 2017

Regulation of connective tissue growth factor (ccn2; ctgf) gene expression in human mesangial cells: modulation by HMG CoA reductase inhibitors (statins).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

11 September 2017

Proteinase-activated receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

11 September 2017

Proliferating bile duct epithelial cells are a major source of connective tissue growth factor in rat biliary fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

11 September 2017

Intermolecular and intramolecular interactions regulate catalytic activity of myotonic dystrophy kinase-related Cdc42-binding kinase alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

11 September 2017

Specificity and mechanism of action of some commonly used protein kinase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

11 September 2017

Tumor necrosis factor alpha suppresses the induction of connective tissue growth factor by transforming growth factor-beta in normal and scleroderma fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

11 September 2017

The structural basis of Rho effector recognition revealed by the crystal structure of human RhoA complexed with the effector domain of PKN/PRK1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

11 September 2017

Activation-dependent adhesion of human platelets to Cyr61 and Fisp12/mouse connective tissue growth factor is mediated through integrin alpha(IIb)beta(3)

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

11 September 2017

https://api.crossref.org/works/10.1074%2FJBC.M710363200

21 January 2018

The connective tissue growth factor/cysteine-rich 61/nephroblastoma overexpressed (CCN) family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

11 September 2017

Thrombin stimulates fibroblast procollagen production via proteolytic activation of protease-activated receptor 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

11 September 2017

Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

11 September 2017

The PRK2 kinase is a potential effector target of both Rho and Rac GTPases and regulates actin cytoskeletal organization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

11 September 2017

p160ROCK, a Rho-associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

11 September 2017

Lysophosphatidic acid: G-protein signalling and cellular responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

11 September 2017

Human connective tissue growth factor is expressed in advanced atherosclerotic lesions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

11 September 2017

A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

11 September 2017

Protein prenylation: molecular mechanisms and functional consequences

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

11 September 2017

The modular architecture of a new family of growth regulators related to connective tissue growth factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

11 September 2017

Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

11 September 2017

rac, a novel ras-related family of proteins that are botulinum toxin substrates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

11 September 2017

Drug-induced gingival overgrowth: old problem, new problem

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

11 September 2017

Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

11 September 2017

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

11 September 2017

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

11 September 2017

Simvastatin inhibits growth factor expression and modulates profibrogenic markers in lung fibroblasts.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

14 September 2017

Expression of connective tissue growth factor in human renal fibroblasts: regulatory roles of RhoA and cAMP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

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Factor VIIa and thrombin induce the expression of Cyr61 and connective tissue growth factor, extracellular matrix signaling proteins that could act as possible downstream mediators in factor VIIa x tissue factor-induced signal transduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

25 September 2017

Expression of connective tissue growth factor in experimental rat and human liver fibrosis

1 reference

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Signaling molecules derived from the cholesterol biosynthetic pathway

1 reference

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25 September 2017

Epithelial and connective tissue cell CTGF/CCN2 expression in gingival fibrosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

17 June 2018

Connective tissue growth factor (CTGF/CCN2) in hepatic fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

17 June 2018

Identification of human ccn2 (connective tissue growth factor) promoter polymorphisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

17 June 2018

The control of ccn2 (ctgf) gene expression in normal and scleroderma fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

17 June 2018

Connective tissue growth factor mRNA expression is upregulated in bleomycin-induced lung fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

17 June 2018

Connective tissue growth factor: a mediator of TGF-beta action on fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

17 June 2018

The rho gene product expressed in E. coli is a substrate of botulinum ADP-ribosyltransferase C3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

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Lovastatin modulates in vivo and in vitro the plasminogen activator/plasmin system of rat proximal tubular cells: role of geranylgeranylation and Rho proteins.

1 reference

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17 June 2018

TGF-beta and Smad3 signaling link inflammation to chronic fibrogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

21 August 2018

Connective tissue growth factor in Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

21 August 2018

Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells

1 reference

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21 August 2018

Connective tissue growth factor in drug-induced gingival overgrowth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

21 August 2018

CTGF and SMADs, maintenance of scleroderma phenotype is independent of SMAD signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

21 August 2018

Increased expression of connective tissue growth factor in fibrotic human liver and in activated hepatic stellate cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

21 August 2018

Naturally occurring analogs of lysophosphatidic acid elicit different cellular responses through selective activation of multiple receptor subtypes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

21 August 2018

The G-protein G13 but not G12 mediates signaling from lysophosphatidic acid receptor via epidermal growth factor receptor to Rho.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435243

21 August 2018

Connective tissue growth factor. Friend or foe?

1 reference

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Epilepsy and the oral manifestations of phenytoin therapy.

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Blood levels of alpha-1-antichymotrypsin and risk factors for Alzheimer's disease: effects of gender and apolipoprotein E genotype.

1 reference

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1 reference

https://pubmed.ncbi.nlm.nih.gov/18287089

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of lysyl oxidase, collagen, and connective tissue growth factor by TGF-beta1 and detection in human gingiva

1 reference

https://pubmed.ncbi.nlm.nih.gov/18287089

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased expression of connective tissue growth factor in the infarct zone of experimentally induced myocardial infarction in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18287089

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevention and treatment considerations in patients with drug-induced gingival enlargement

1 reference

https://pubmed.ncbi.nlm.nih.gov/18287089

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of connective tissue growth factor in human renal fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18287089

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of transforming growth factor-beta in transdifferentiation and fibrosis of lens epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18287089

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Constitutive connective tissue growth factor expression in scleroderma fibroblasts is dependent on Sp1

1 reference

https://pubmed.ncbi.nlm.nih.gov/18287089

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of TGF-beta 1, -beta 2 and -beta 3 in localized and systemic scleroderma

1 reference

https://pubmed.ncbi.nlm.nih.gov/18287089

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/18287089

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abundant retention and release of connective tissue growth factor (CTGF/CCN2) by platelets

1 reference

https://pubmed.ncbi.nlm.nih.gov/18287089

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Connective tissue growth factor is a regulator for fibrosis in human chronic pancreatitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18287089

12 December 2020

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inferred from PubMed ID database lookup

Enhanced insulin-like growth factor binding protein-related protein 2 (Connective tissue growth factor) expression in patients with idiopathic pulmonary fibrosis and pulmonary sarcoidosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18287089

12 December 2020

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Establishment of the enzyme-linked immunosorbent assay for connective tissue growth factor (CTGF) and its detection in the sera of biliary atresia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18287089

12 December 2020

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Regulation of connective tissue growth factor activity in cultured rat mesangial cells and its expression in experimental diabetic glomerulosclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18287089

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Connective tissue growth factor: a novel regulator of mucosal repair and fibrosis in inflammatory bowel disease?

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https://pubmed.ncbi.nlm.nih.gov/18287089

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Identifiers

10.1074/JBC.M710363200

1 reference

Europe PubMed Central

PMC publication ID

11 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 September 2017

ResearchGate publication ID

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