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Hypoxic activation of ATR and the suppression of the initiation of DNA replication through cdc6 degradation
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Europe PubMed Central
PMC publication ID
3310967
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22179839%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 January 2020
title
Hypoxic activation of ATR and the suppression of the initiation of DNA replication through cdc6 degradation
(English)
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stated in
Europe PubMed Central
PMC publication ID
3310967
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22179839%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 January 2020
main subject
hypoxia
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author
Michael D Rainey
series ordinal
2
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Europe PubMed Central
PMC publication ID
3310967
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22179839%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 January 2020
Corrado Santocanale
series ordinal
3
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stated in
Europe PubMed Central
PMC publication ID
3310967
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22179839%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 January 2020
Lawrence Gardner
series ordinal
4
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stated in
Europe PubMed Central
PMC publication ID
3310967
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22179839%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 January 2020
author name string
L Martin
series ordinal
1
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Europe PubMed Central
PMC publication ID
3310967
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22179839%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 January 2020
language of work or name
English
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publication date
19 December 2011
1 reference
stated in
Europe PubMed Central
PMC publication ID
3310967
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22179839%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 January 2020
published in
Oncogene
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stated in
Europe PubMed Central
PMC publication ID
3310967
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22179839%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 January 2020
volume
31
1 reference
stated in
Europe PubMed Central
PMC publication ID
3310967
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22179839%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 January 2020
issue
36
1 reference
stated in
Europe PubMed Central
PMC publication ID
3310967
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22179839%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 January 2020
page(s)
4076-4084
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stated in
Europe PubMed Central
PMC publication ID
3310967
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22179839%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 January 2020
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Cdc6 stability is regulated by the Huwe1 ubiquitin ligase after DNA damage
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The APC/C inhibitor, Emi1, is essential for prevention of rereplication
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The functional role of Cdc6 in S-G2/M in mammalian cells
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CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis
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Involvement of the SCF complex in the control of Cdh1 degradation in S-phase
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The role of ATM and ATR in the cellular response to hypoxia and re-oxygenation
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11 September 2017
Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases
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HIF-1alpha induces cell cycle arrest by functionally counteracting Myc.
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11 September 2017
Replication protein A (RPA) phosphorylation prevents RPA association with replication centers
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Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage
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Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo
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11 September 2017
An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication
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11 September 2017
An ATR- and Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damage
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11 September 2017
Hypoxia links ATR and p53 through replication arrest
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11 September 2017
Analysis of Cdc6 function in the assembly of mammalian prereplication complexes
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11 September 2017
Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex
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11 September 2017
Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis
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11 September 2017
Rapid destruction of human Cdc25A in response to DNA damage
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11 September 2017
ATR disruption leads to chromosomal fragmentation and early embryonic lethality
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11 September 2017
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11 September 2017
Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication
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11 September 2017
CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase
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11 September 2017
Cdc6 protein causes premature entry into S phase in a mammalian cell-free system
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11 September 2017
Cell cycle-regulated expression of mammalian CDC6 is dependent on E2F.
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11 September 2017
Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.
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11 September 2017
Ultraviolet radiation inhibits replicon initiation in S phase human cells
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11 September 2017
p21(Cip1) and p27(Kip1) regulate cell cycle reentry after hypoxic stress but are not necessary for hypoxia-induced arrest
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11 September 2017
Regulation of proliferation-survival decisions during tumor cell hypoxia
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Coordinated activation of the origin licensing factor CDC6 and CDK2 in resting human fibroblasts expressing SV40 small T antigen and cyclin E.
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14 September 2017
Hypoxic suppression of the cell cycle gene CDC25A in tumor cells
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14 September 2017
Inhibition of ATR leads to increased sensitivity to hypoxia/reoxygenation
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14 September 2017
Anoxic fibroblasts activate a replication checkpoint that is bypassed by E1a
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14 September 2017
ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation
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Tumor hypoxia and the cell cycle: implications for malignant progression and response to therapy
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17 June 2018
Hypoxia-mediated regulation of Cdc25A phosphatase by p21 and miR-21.
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21 August 2018
Comparison of hypoxia-induced replication arrest with hydroxyurea and aphidicolin-induced arrest
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21 August 2018
The range of oxygenation in SiHa tumor xenografts
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21 August 2018
Hypoxia inhibits G1/S transition through regulation of p27 expression
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31 March 2020
Oxygenation of human tumors: evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22179839
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1038/ONC.2011.585
1 reference
stated in
Europe PubMed Central
PMC publication ID
3310967
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22179839%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 January 2020
PMC publication ID
3310967
1 reference
stated in
Europe PubMed Central
PMC publication ID
3310967
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22179839%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 January 2020
PubMed publication ID
22179839
1 reference
stated in
Europe PubMed Central
PMC publication ID
3310967
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22179839%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 January 2020
ResearchGate publication ID
51898399
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