(Q39446169)

12 September 2017

title

Early prediction of instability of Chinese hamster ovary cell lines expressing recombinant antibodies and antibody-fusion proteins (English)

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12 September 2017

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8

Michael J Betenbaugh

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12 September 2017

Haimanti Dorai

1

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12 September 2017

Susanne Corisdeo

2

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12 September 2017

Dawn Ellis

3

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12 September 2017

Cherylann Kinney

4

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12 September 2017

Matt Chomo

5

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12 September 2017

Pam Hawley-Nelson

6

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12 September 2017

Gordon Moore

7

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12 September 2017

Subinay Ganguly

9

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12 September 2017

publication date

1 December 2011

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Biotechnology and Bioengineering

12 September 2017

published in

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12 September 2017

volume

109

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12 September 2017

issue

4

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12 September 2017

page(s)

1016-1030

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Advances in animal cell recombinant protein production: GS-NS0 expression system

12 September 2017

cites work

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Characterization of the stability of recombinant protein production in the GS-NS0 expression system

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Stability of protein production from recombinant mammalian cells

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Stability of recombinant protein production in the GS-NS0 expression system is unaffected by cryopreservation

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Molecular definition of predictive indicators of stable protein expression in recombinant NS0 myeloma cells

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Mammalian cell factories for efficient and stable protein expression

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High-level expression of a recombinant antibody from myeloma cells using a glutamine synthetase gene as an amplifiable selectable marker

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An embarrassment of niches: the many covalent modifications of histones in transcriptional regulation.

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Analysis of changes during subclone development and ageing of human antibody-producing heterohybridoma cells by northern blot and flow cytometry.

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A simple method for enriching populations of transfected CHO cells for cells of higher specific productivity

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Process development for the production of recombinant antibodies using the glutamine synthetase (GS) system

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Therapeutic antibodies for autoimmunity and inflammation

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Population balance between producing and nonproducing hybridoma clones is very sensitive to serum level, state of inoculum, and medium composition

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Relationship between loss of heavy chains and the appearance of nonproducing hybridomas

21 January 2018

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Correlation of heavy and light chain mRNA copy numbers to antibody productivity in mouse myeloma production cell lines

21 January 2018

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Development of mammalian production cell lines expressing CNTO736, a glucagon like peptide-1-MIMETIBODY: factors that influence productivity and product quality

21 January 2018

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Combining high-throughput screening of caspase activity with anti-apoptosis genes for development of robust CHO production cell lines

21 January 2018

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The gel microdrop secretion assay: Identification of a low productivity subpopulation arising during the production of human antibody in CHO cells

21 January 2018

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Chromatin remodeling and transcription.

21 January 2018

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Optimization of tetracycline-responsive recombinant protein production and effect on cell growth and ER stress in mammalian cells

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Loss and stabilization of amplified dihydrofolate reductase genes in mouse sarcoma S-180 cell lines

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Stability of producer hybridoma cell lines after cell sorting: a case study

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Immobilization can improve the stability of hybridoma antibody productivity in serum-free media

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Manipulation of heterogeneous hybridoma cultures for overproduction of monoclonal antibodies

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Loss of antibody productivity is highly reproducible in multiple hybridoma subclones

21 January 2018

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Stabilized, long-term expression of heterodimeric proteins from tricistronic mRNA.

21 January 2018

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Variation in apoptosis profiles in radiation-induced genomically unstable cell lines.

21 January 2018

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Loss of antibody productivity during long-term cultivation of a hybridoma cell line in low serum and serum-free media

21 January 2018

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Effects of methotrexate on transfected DNA stability in mammalian cells

21 January 2018

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Cell cycle kinetics and monoclonal antibody productivity of hybridoma cells during perfusion culture

21 January 2018

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Antigen-specific identification and cloning of hybridomas with a fluorescence-activated cell sorter

21 January 2018

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A study on the temperature dependency and time course of the cold capture antibody secretion assay

21 January 2018

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Coupling endoplasmic reticulum stress to the cell death program

21 January 2018

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A trip to the ER: coping with stress

21 January 2018

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Flow cytometric study of hybridoma cell culture: correlation between cell surface fluorescence and IgG production rate

21 January 2018

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Changes during subclone development and ageing of human antibody-producing recombinant CHO cells

21 January 2018

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Disruption of higher-order folding by core histone acetylation dramatically enhances transcription of nucleosomal arrays by RNA polymerase III

21 January 2018

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Amplified gene location in chromosomal DNA affected recombinant protein production and stability of amplified genes.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/BIT.24367

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12 September 2017

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