(Q39458884)

English

Polyubiquitination of insulin-like growth factor I receptor (IGF-IR) activation loop promotes antibody-induced receptor internalization and down-regulation

scientific article published on 12 October 2011

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

Polyubiquitination of insulin-like growth factor I receptor (IGF-IR) activation loop promotes antibody-induced receptor internalization and down-regulation (English)

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

author name string

Yifan Mao

1

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

Yonglei Shang

2

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

Victoria C Pham

3

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

James A Ernst

4

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

Jennie R Lill

5

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

Suzie J Scales

6

1 reference

Europe PubMed Central

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12 September 2017

Jiping Zha

7

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Europe PubMed Central

PMC publication ID

12 September 2017

language of work or name

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publication date

12 October 2011

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Europe PubMed Central

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12 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

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12 September 2017

286

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Europe PubMed Central

PMC publication ID

12 September 2017

48

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

41852-41861

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

Improved quantitative mass spectrometry methods for characterizing complex ubiquitin signals

1 reference

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Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling

1 reference

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Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation

1 reference

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12 September 2017

Nonproteolytic functions of ubiquitin in cell signaling

1 reference

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12 September 2017

Identification of c-Cbl as a new ligase for insulin-like growth factor-I receptor with distinct roles from Mdm2 in receptor ubiquitination and endocytosis

1 reference

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12 September 2017

Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor

1 reference

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12 September 2017

Atypical ubiquitin chains: new molecular signals. 'Protein Modifications: Beyond the Usual Suspects' review series

1 reference

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12 September 2017

Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains

1 reference

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The age of crosstalk: phosphorylation, ubiquitination, and beyond

1 reference

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12 September 2017

Regulation of receptors and transporters by ubiquitination: new insights into surprisingly similar mechanisms

1 reference

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12 September 2017

Role of ubiquitination in IGF-1 receptor signaling and degradation

1 reference

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12 September 2017

Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains

1 reference

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Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain

1 reference

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12 September 2017

Targeting insulin-like growth factor pathways.

1 reference

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12 September 2017

Weighing in on ubiquitin: the expanding role of mass-spectrometry-based proteomics

1 reference

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The mitochondrial inner membrane protein mitofilin controls cristae morphology

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12 September 2017

Endocytosis and sorting of ErbB2 and the site of action of cancer therapeutics trastuzumab and geldanamycin

1 reference

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12 September 2017

Insulin-like growth factors and neoplasia.

1 reference

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12 September 2017

Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases

1 reference

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12 September 2017

A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo.

1 reference

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12 September 2017

The IGF‐1 receptor in cancer biology

1 reference

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12 September 2017

Structure of apo, unactivated insulin-like growth factor-1 receptor kinase at 1.5 Å resolution

1 reference

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12 September 2017

Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor

1 reference

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12 September 2017

The insulin-like growth factor system and cancer

1 reference

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12 September 2017

Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation

1 reference

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12 September 2017

The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor

1 reference

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12 September 2017

Negative receptor signalling

1 reference

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12 September 2017

Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein

1 reference

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12 September 2017

Structure and autoregulation of the insulin-like growth factor 1 receptor kinase

1 reference

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12 September 2017

Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1

1 reference

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12 September 2017

A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein

1 reference

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Antixenograft tumor activity of a humanized anti-insulin-like growth factor-I receptor monoclonal antibody is associated with decreased AKT activation and glucose uptake.

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14 September 2017

Grb10/Nedd4-mediated multiubiquitination of the insulin-like growth factor receptor regulates receptor internalization

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Degradation of insulin-like growth factor-I receptor occurs via ubiquitin-proteasome pathway in human lung cancer cells

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Inhibition of insulin-like growth factor-I receptor (IGF-IR) signaling and tumor cell growth by a fully human neutralizing anti-IGF-IR antibody

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14 September 2017

Mitogenicity and transforming activity of the insulin-like growth factor-I receptor with mutations in the tyrosine kinase domain.

1 reference

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TRAF7 protein promotes Lys-29-linked polyubiquitination of IkappaB kinase (IKKgamma)/NF-kappaB essential modulator (NEMO) and p65/RelA protein and represses NF-kappaB activation

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In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase

1 reference

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A uniform isopeptide-linked multiubiquitin chain is sufficient to target substrate for degradation in ubiquitin-mediated proteolysis

1 reference

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Molecular mechanisms involved in activity of h7C10, a humanized monoclonal antibody, to IGF-1 receptor.

1 reference

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21 August 2018

Combination therapy enhances the inhibition of tumor growth with the fully human anti-type 1 insulin-like growth factor receptor monoclonal antibody CP-751,871.

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21 August 2018

A recombinant humanized anti-insulin-like growth factor receptor type I antibody (h7C10) enhances the antitumor activity of vinorelbine and anti-epidermal growth factor receptor therapy against human cancer xenografts

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Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors

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21 August 2018

An anti-insulin-like growth factor I receptor antibody that is a potent inhibitor of cancer cell proliferation

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21 August 2018

Identifiers

10.1074/JBC.M111.288514

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

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