(Q39485974)

12 September 2017

title

Methylglyoxal impairs insulin signalling and insulin action on glucose-induced insulin secretion in the pancreatic beta cell line INS-1E. (English)

1 reference

insulin secretion involved in cellular response to glucose stimulus

12 September 2017

0 references

0 references

1 reference

1 reference

F Fiory

1

1 reference

12 September 2017

A Lombardi

2

1 reference

12 September 2017

C Miele

3

1 reference

12 September 2017

J Giudicelli

4

1 reference

12 September 2017

F Beguinot

5

1 reference

12 September 2017

E Van Obberghen

6

1 reference

12 September 2017

publication date

23 August 2011

1 reference

12 September 2017

1 reference

12 September 2017

volume

54

1 reference

12 September 2017

issue

11

1 reference

12 September 2017

page(s)

2941-2952

1 reference

https://scigraph.springernature.com/pub.10.1007/s00125-011-2280-8

12 September 2017

exact match

0 references

cites work

The metabolic syndrome--from insulin resistance to obesity and diabetes

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2280-8

Reduced expression of the insulin receptor in mouse insulinoma (MIN6) cells reveals multiple roles of insulin signaling in gene expression, proliferation, insulin content, and secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2280-8

Regulation of gene expression by glucose in pancreatic beta -cells (MIN6) via insulin secretion and activation of phosphatidylinositol 3'-kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2280-8

Exocytosis of insulin promotes insulin gene transcription via the insulin receptor/PI-3 kinase/p70 s6 kinase and CaM kinase pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2280-8

Roles of insulin receptor substrate-1, phosphatidylinositol 3-kinase, and release of intracellular Ca2+ stores in insulin-stimulated insulin secretion in beta -cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2280-8

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2280-8

Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2280-8

Disruption of IRS-2 causes type 2 diabetes in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2280-8

Distinct roles for insulin and insulin-like growth factor-1 receptors in pancreatic beta-cell glucose sensing revealed by RNA silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2280-8

Modulation of insulin action by advanced glycation endproducts: a new player in the field

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2280-8

Glyoxalase I--structure, function and a critical role in the enzymatic defence against glycation

21 January 2018

2 references

https://api.crossref.org/works/10.1007%2FS00125-011-2280-8

21 January 2018

12 December 2020

Human glycated albumin affects glucose metabolism in L6 skeletal muscle cells by impairing insulin-induced insulin receptor substrate (IRS) signaling through a protein kinase C alpha-mediated mechanism

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2280-8

In skeletal muscle advanced glycation end products (AGEs) inhibit insulin action and induce the formation of multimolecular complexes including the receptor for AGEs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2280-8

Methylglyoxal impairs the insulin signaling pathways independently of the formation of intracellular reactive oxygen species

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2280-8

Reactive oxygen species as a signal in glucose-stimulated insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2280-8

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2280-8

Cytotoxic action of methylglyoxal on insulin-secreting cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2280-8

Aminoacetone, a putative endogenous source of methylglyoxal, causes oxidative stress and death to insulin-producing RINm5f cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2280-8

Chronic methylglyoxal infusion by minipump causes pancreatic beta-cell dysfunction and induces type 2 diabetes in Sprague-Dawley rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2280-8

miR-375 targets 3'-phosphoinositide-dependent protein kinase-1 and regulates glucose-induced biological responses in pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2280-8

Glucagon-like peptide-1 protects beta cells from cytokine-induced apoptosis and necrosis: role of protein kinase B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2280-8

Prep1 deficiency induces protection from diabetes and increased insulin sensitivity through a p160-mediated mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2280-8

Glucose Sensitivity and Metabolism-Secretion Coupling Studied during Two-Year Continuous Culture in INS-1E Insulinoma Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2280-8

Selective induction of heparin-binding epidermal growth factor-like growth factor by methylglyoxal and 3-deoxyglucosone in rat aortic smooth muscle cells. The involvement of reactive oxygen species formation and a possible implication for atherogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2280-8

Insulin stimulates pancreatic-duodenal homoeobox factor-1 (PDX1) DNA-binding activity and insulin promoter activity in pancreatic beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2280-8

Glucose regulates steady-state levels of PDX1 via the reciprocal actions of GSK3 and AKT kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2280-8

Mice with beta cell overexpression of glycogen synthase kinase-3beta have reduced beta cell mass and proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2280-8

Lithium and GSK-3: one inhibitor, two inhibitory actions, multiple outcomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2280-8

Glucose and insulin treatment of insulinoma cells results in transcriptional regulation of a common set of genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2280-8

Diabetes associated cell stress and dysfunction: role of mitochondrial and non-mitochondrial ROS production and activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2280-8

Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2280-8

Surfing the insulin signaling web

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2280-8

The p38/reactivating kinase mitogen-activated protein kinase cascade mediates the activation of the transcription factor insulin upstream factor 1 and insulin gene transcription by high glucose in pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2280-8

PDX-1 and MafA play a crucial role in pancreatic beta-cell differentiation and maintenance of mature beta-cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2280-8

Modulation of glucose responsiveness of insulinoma beta-cells by graded overexpression of glucokinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2280-8

Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2280-8

The chaperone-dependent ubiquitin ligase CHIP targets HIF-1α for degradation in the presence of methylglyoxal

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2280-8

Insulin receptor substrate 1-induced inhibition of endoplasmic reticulum Ca2+ uptake in beta-cells. Autocrine regulation of intracellular ca2+ homeostasis and insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2280-8

Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2280-8

High glucose-induced impairment in insulin secretion is associated with reduction in islet glucokinase in a mouse model of susceptibility to islet dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2280-8

Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2280-8

GSK-3 inactivation or depletion promotes β-cell replication via down regulation of the CDK inhibitor, p27 (Kip1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2280-8

Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2280-8

Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2280-8

Effects of Methylglyoxal on Rat Pancreatic β-Cells

21 January 2018

1 reference

12 December 2020

The IRS-signaling system: a network of docking proteins that mediate insulin and cytokine action

1 reference

12 December 2020

Endogenous alpha-oxoaldehydes and formation of protein and nucleotide advanced glycation endproducts in tissue damage.

1 reference

12 December 2020

Insulin receptor signaling in the beta-cell influences insulin gene expression and insulin content: evidence for autocrine beta-cell regulation

1 reference

12 December 2020

10.1007/S00125-011-2280-8

Identifiers

DOI

1 reference

12 September 2017

1 reference