(Q39578562)

English

Pregnane X Receptor Activation Attenuates Inflammation-Associated Intestinal Epithelial Barrier Dysfunction by Inhibiting Cytokine-Induced Myosin Light-Chain Kinase Expression and c-Jun N-Terminal Kinase 1/2 Activation

scientific article published on 20 July 2016

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scholarly article

1 reference

Europe PubMed Central

6 October 2017

Pregnane X Receptor Activation Attenuates Inflammation-Associated Intestinal Epithelial Barrier Dysfunction by Inhibiting Cytokine-Induced Myosin Light-Chain Kinase Expression and c-Jun N-Terminal Kinase 1/2 Activation (English)

1 reference

Europe PubMed Central

6 October 2017

author name string

Aditya Garg

1

1 reference

Europe PubMed Central

6 October 2017

Angela Zhao

2

1 reference

Europe PubMed Central

6 October 2017

Sarah L Erickson

3

1 reference

Europe PubMed Central

6 October 2017

Subhajit Mukherjee

4

1 reference

Europe PubMed Central

6 October 2017

Aik Jiang Lau

5

1 reference

Europe PubMed Central

6 October 2017

Laurie Alston

6

1 reference

Europe PubMed Central

6 October 2017

Thomas K H Chang

7

1 reference

Europe PubMed Central

6 October 2017

Sridhar Mani

8

1 reference

Europe PubMed Central

6 October 2017

Simon A Hirota

9

1 reference

Europe PubMed Central

6 October 2017

language of work or name

0 references

publication date

20 July 2016

1 reference

Europe PubMed Central

6 October 2017

Journal of Pharmacology and Experimental Therapeutics

1 reference

Europe PubMed Central

6 October 2017

359

1 reference

Europe PubMed Central

6 October 2017

1

1 reference

Europe PubMed Central

6 October 2017

91-101

1 reference

Europe PubMed Central

6 October 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5034705/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

3-Hydroxyflavone and structural analogues differentially activate pregnane X receptor: Implication for inflammatory bowel disease

1 reference

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1 reference

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Calcium/Ask1/MKK7/JNK2/c-Src signalling cascade mediates disruption of intestinal epithelial tight junctions by dextran sulfate sodium

1 reference

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1 reference

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1 reference

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1 reference

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Myosin light chain kinase: pulling the strings of epithelial tight junction function

1 reference

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Pregnane X receptor PXR activates the GADD45beta gene, eliciting the p38 MAPK signal and cell migration

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Identification of clinically used drugs that activate pregnane X receptors

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NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis

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Pregnane-X-receptor mediates the anti-inflammatory activities of rifaximin on detoxification pathways in intestinal epithelial cells

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Therapeutic role of rifaximin in inflammatory bowel disease: clinical implication of human pregnane X receptor activation

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The protective role of pregnane X receptor in lipopolysaccharide/D-galactosamine-induced acute liver injury

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Intestinal mucosal barrier function in health and disease

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Modulation of pregnane X receptor- and electrophile responsive element-mediated gene expression by dietary polyphenolic compounds

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IFN-gamma-induced TNFR2 expression is required for TNF-dependent intestinal epithelial barrier dysfunction

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Mutual repression between steroid and xenobiotic receptor and NF-kappaB signaling pathways links xenobiotic metabolism and inflammation

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Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression

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A differentiation-dependent splice variant of myosin light chain kinase, MLCK1, regulates epithelial tight junction permeability

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Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms

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1 reference

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Knockout of the c-Jun N-terminal Kinase 2 aggravates the development of mild chronic dextran sulfate sodium colitis independently of expression of intestinal cytokines TNFα, TGFB1, and IL-6.

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Intestinal permeability test as a predictor of clinical course in Crohn's disease

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https://pubmed.ncbi.nlm.nih.gov/27440420

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inferred from PubMed ID database lookup

Increased intestinal permeability in patients with Crohn's disease and their relatives. A possible etiologic factor

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https://pubmed.ncbi.nlm.nih.gov/27440420

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The specific JNK inhibitor SP600125 targets tumour necrosis factor-alpha production and epithelial cell apoptosis in acute murine colitis

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Role of the PXR gene locus in inflammatory bowel diseases

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Rifaximin for the treatment of active pouchitis: a randomized, double-blind, placebo-controlled pilot study

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Abnormal intestinal permeability in Crohn's disease pathogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/27440420

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1124/JPET.116.234096

1 reference

Europe PubMed Central

6 October 2017

1 reference

Europe PubMed Central

6 October 2017

1 reference

Europe PubMed Central

6 October 2017

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