(Q39606000)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21246394%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

title

Lonafarnib (SCH66336) improves the activity of temozolomide and radiation for orthotopic malignant gliomas (English)

1 reference

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20 January 2020

11

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20 January 2020

Mark W. Kieran

13

1 reference

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20 January 2020

10

Patrick Y Wen

1 reference

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20 January 2020

5

Eva Fast

1 reference

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20 January 2020

author name string

Deviney Chaponis

1

1 reference

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20 January 2020

Jessica W Barnes

2

1 reference

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20 January 2020

Jamie L Dellagatta

3

1 reference

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20 January 2020

Santosh Kesari

4

1 reference

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20 January 2020

Claire Sauvageot

6

1 reference

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20 January 2020

Dipak Panagrahy

7

1 reference

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20 January 2020

Emily R Greene

8

1 reference

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20 January 2020

Naren Ramakrishna

9

1 reference

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20 January 2020

Charles Stiles

12

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20 January 2020

publication date

19 January 2011

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Journal of Neuro-Oncology

20 January 2020

published in

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20 January 2020

volume

104

1 reference

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20 January 2020

issue

1

1 reference

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20 January 2020

page(s)

179-189

1 reference

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describes a project that uses

20 January 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4898271/fullTextXML

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1007/s11060-010-0502-4

0 references

cites work

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Phase II preradiation R115777 (tipifarnib) in newly diagnosed GBM with residual enhancing disease

14 September 2017

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Phase I trial of tipifarnib in children with newly diagnosed intrinsic diffuse brainstem glioma

14 September 2017

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Chemoresistance in gliomas

14 September 2017

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Epidermal growth factor receptor and glioblastoma multiforme: molecular basis for a new approach.

14 September 2017

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Targeting the epidermal growth factor receptor in high-grade astrocytomas

14 September 2017

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Glioblastoma multiforme: evidence-based approach to therapy

14 September 2017

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Molecular pathogenesis of adult brain tumors and the role of stem cells

14 September 2017

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Genetic pathways to primary and secondary glioblastoma

14 September 2017

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Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma

14 September 2017

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Lonafarnib in cancer therapy.

14 September 2017

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A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors.

14 September 2017

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Identification of a cancer stem cell in human brain tumors

14 September 2017

1 reference

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Manipulation of EphB2 regulatory motifs and SH2 binding sites switches MAPK signaling and biological activity

14 September 2017

1 reference

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Promising survival for patients with newly diagnosed glioblastoma multiforme treated with concomitant radiation plus temozolomide followed by adjuvant temozolomide

14 September 2017

1 reference

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Downregulation of the Ras-mitogen-activated protein kinase pathway by the EphB2 receptor tyrosine kinase is required for ephrin-induced neurite retraction

14 September 2017

1 reference

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Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: lessons from mechanism and bench-to-bedside translational studies

14 September 2017

1 reference

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Inhibition of cell growth in human glioblastoma cell lines by farnesyltransferase inhibitor SCH66336.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898271

Signaling pathways in the induction of c-met receptor expression by its ligand scatter factor/hepatocyte growth factor in human glioblastoma.

14 September 2017

1 reference

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Validation and predictive power of Radiation Therapy Oncology Group (RTOG) recursive partitioning analysis classes for malignant glioma patients: a report using RTOG 90-06.

14 September 2017

1 reference

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Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells

14 September 2017

1 reference

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K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

14 September 2017

1 reference

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Regulation of cell motility by mitogen-activated protein kinase

14 September 2017

1 reference

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Radioresistance induced by oncogenic transformation

14 September 2017

1 reference

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The role of the H-ras oncogene in radiation resistance and metastasis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898271

Inhibition of telomerase in the endothelial cells disrupts tumor angiogenesis in glioblastoma xenografts

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898271

Telomerase inhibition impairs tumor growth in glioblastoma xenografts

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898271

Noninvasive bioluminescence imaging of luciferase expressing intracranial U87 xenografts: correlation with magnetic resonance imaging determined tumor volume and longitudinal use in assessing tumor growth and antiangiogenic treatment effect

14 September 2017

1 reference

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The farnesyl transferase inhibitor (FTI) SCH66336 (lonafarnib) inhibits Rheb farnesylation and mTOR signaling. Role in FTI enhancement of taxane and tamoxifen anti-tumor activity

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898271

Farnesyltransferase inhibitor SCH-66336 downregulates secretion of matrix proteinases and inhibits carcinoma cell migration.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898271

Farnesyltransferase inhibitor effects on prostate tumor micro-environment and radiation survival

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898271

In vitro study of farnesyltransferase inhibitor SCH 66336, in combination with chemotherapy and radiation, in non-small cell lung cancer cell lines.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898271

Ras CAAX Peptidomimetic FTI-277 Selectively Blocks Oncogenic Ras Signaling by Inducing Cytoplasmic Accumulation of Inactive Ras-Raf Complexes

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898271

Orally bioavailable farnesyltransferase inhibitors as anticancer agents in transgenic and xenograft models

25 September 2017

1 reference

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Differences in radiation-induced micronuclei yields of human cells: influence of ras gene expression and protein localization

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898271

Inhibiting Ras prenylation increases the radiosensitivity of human tumor cell lines with activating mutations of ras oncogenes.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898271

Farnesyltransferase inhibitors target multiple endothelial cell functions in angiogenesis.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898271

Cancer stem cells in radiation resistance.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898271

Phase I and pharmacokinetic study of the oral farnesyltransferase inhibitor lonafarnib administered twice daily to pediatric patients with advanced central nervous system tumors using a modified continuous reassessment method: a Pediatric Brain Tumo

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898271

Combination of sublethal concentrations of epidermal growth factor receptor inhibitor and microtubule stabilizer induces apoptosis of glioblastoma cells.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898271

Phase I trial and pharmacokinetic study of the farnesyltransferase inhibitor tipifarnib in children with refractory solid tumors or neurofibromatosis type I and plexiform neurofibromas

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898271

Apoptosis and proliferation: correlation with p53 in astrocytic tumours.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898271

Mutation analysis of the Ras pathway genes NRAS, HRAS, KRAS and BRAF in glioblastomas.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898271

The epidermal growth factor receptor pathway mediates resistance to sequential administration of radiation and chemotherapy in primary human glioblastoma cells in a RAS-dependent manner.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898271

Growth inhibition of astrocytoma cells by farnesyl transferase inhibitors is mediated by a combination of anti-proliferative, pro-apoptotic and anti-angiogenic effects.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898271

Expression of activated epidermal growth factor receptors, Ras-guanosine triphosphate, and mitogen-activated protein kinase in human glioblastoma multiforme specimens

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898271

Inhibition of Ras and related guanosine triphosphate-dependent proteins as a therapeutic strategy for blocking malignant glioma growth: II--preclinical studies in a nude mouse model.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898271

EphB ligand, ephrinB2, suppresses the VEGF- and angiopoietin 1-induced Ras/mitogen-activated protein kinase pathway in venous endothelial cells

21 August 2018

1 reference

12 December 2020

Ras regulation of radioresistance in cell culture

1 reference

12 December 2020

A peptidomimetic inhibitor of farnesyl:protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines

1 reference

12 December 2020

SCH66336, inhibitor of protein farnesylation, blocks signal transducer and activators of transcription 3 signaling in lung cancer and interacts with a small molecule inhibitor of epidermal growth factor receptor/human epidermal growth factor recepto

1 reference

12 December 2020

10.1007/S11060-010-0502-4

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21246394%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21246394%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

PubMed publication ID

21246394

1 reference