(Q40399733)

English

The farnesyl transferase inhibitor (FTI) SCH66336 (lonafarnib) inhibits Rheb farnesylation and mTOR signaling. Role in FTI enhancement of taxane and tamoxifen anti-tumor activity

scientific article published on 8 July 2005

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

The farnesyl transferase inhibitor (FTI) SCH66336 (lonafarnib) inhibits Rheb farnesylation and mTOR signaling. Role in FTI enhancement of taxane and tamoxifen anti-tumor activity (English)

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

1 reference

based on heuristic

inferred from title

author name string

Andrea D Basso

1

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

Asra Mirza

2

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

Gongjie Liu

3

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

Brian J Long

4

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

W Robert Bishop

5

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

Paul Kirschmeier

6

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

language of work or name

0 references

publication date

8 July 2005

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

280

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

35

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

31101-31108

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

A novel approach for expression cloning of small GTPases: identification, tissue distribution and chromosome mapping of the human homolog of rheb

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503763200

21 January 2018

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503763200

21 January 2018

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503763200

21 January 2018

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503763200

21 January 2018

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503763200

21 January 2018

Identification and characterization of the tuberous sclerosis gene on chromosome 16

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503763200

21 January 2018

Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503763200

21 January 2018

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503763200

21 January 2018

Regulation of TSC2 by 14-3-3 binding

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503763200

21 January 2018

Akt regulates growth by directly phosphorylating Tsc2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503763200

21 January 2018

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503763200

21 January 2018

The LKB1 tumor suppressor negatively regulates mTOR signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503763200

21 January 2018

TSC2 mediates cellular energy response to control cell growth and survival

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503763200

21 January 2018

Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503763200

21 January 2018

A serine/threonine kinase gene defective in Peutz-Jeghers syndrome

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503763200

21 January 2018

Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503763200

21 January 2018

Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503763200

21 January 2018

Rheb binds and regulates the mTOR kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503763200

21 January 2018

The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503763200

21 January 2018

Drosophila Rheb GTPase is required for cell cycle progression and cell growth

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503763200

21 January 2018

Rheb promotes cell growth as a component of the insulin/TOR signalling network

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503763200

21 January 2018

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503763200

21 January 2018

The Ras-related protein Rheb is farnesylated and antagonizes Ras signaling and transformation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503763200

21 January 2018

The Saccharomyces cerevisiae Rheb G-protein is involved in regulating canavanine resistance and arginine uptake

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503763200

21 January 2018

Sequence requirement for peptide recognition by rat brain p21ras protein farnesyltransferase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503763200

21 January 2018

A protein geranylgeranyltransferase from bovine brain: implications for protein prenylation specificity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503763200

21 January 2018

p21ras is modified by a farnesyl isoprenoid

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503763200

21 January 2018

The tyrosine phosphatase PRL-1 localizes to the endoplasmic reticulum and the mitotic spindle and is required for normal mitosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503763200

21 January 2018

Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503763200

21 January 2018

Farnesyl transferase inhibitors cause enhanced mitotic sensitivity to taxol and epothilones

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503763200

21 January 2018

Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503763200

21 January 2018

Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503763200

21 January 2018

Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503763200

21 January 2018

Farnesyltransferase inhibitor induces rapid growth arrest and blocks p70s6k activation by multiple stimuli

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503763200

21 January 2018

Targeting mammalian target of rapamycin synergistically enhances chemotherapy-induced cytotoxicity in breast cancer cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503763200

21 January 2018

Inhibition of mTOR activity restores tamoxifen response in breast cancer cells with aberrant Akt Activity.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503763200

21 January 2018

Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503763200

21 January 2018

PIK3CA is implicated as an oncogene in ovarian cancer.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503763200

21 January 2018

Allelic loss of chromosome 10q23 is associated with tumor progression in breast carcinomas

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503763200

21 January 2018

PTEN/MMAC1/TEP1 involvement in primary prostate cancers.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503763200

21 January 2018

Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503763200

21 January 2018

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503763200

21 January 2018

Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503763200

21 January 2018

Farnesyltransferase inhibitor tipifarnib is well tolerated, induces stabilization of disease, and inhibits farnesylation and oncogenic/tumor survival pathways in patients with advanced multiple myeloma

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503763200

21 January 2018

The farnesyl transferase inhibitor SCH 66336 induces a G(2) --> M or G(1) pause in sensitive human tumor cell lines

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503763200

21 January 2018

Identifiers

10.1074/JBC.M503763200

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

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